Serum creatinine =< 1.2 x ULN or creatinine clearance >= 60 mL/min; obtained within 14 days prior to study entry
Creatinine clearance >= 45 ml/min documented within 28 days prior to step 1 registration
Calculated (calc.) creatinine clearance >= 50 mL/min\r\n* Estimated creatinine clearance for patients >= 18 years old will be estimated by the Jelliffe equation modified for body surface area (BSA); patients with creatinine clearance estimated > 70ml/min by this formula are eligible; if the creatinine clearance estimated by the Jelliffe method is >= 50 mL/min but =< 70 mL/min, then a second method to confirm a creatinine clearance of >= 50 mL/min is required; methods of estimating glomerular filtration rate (GFR) that can be used for this confirmation consist of a 12 or 24-hour urine creatinine clearance or a nuclear creatinine clearance test; if the confirmatory creatinine clearance is < 50 mL/min, then the patient is not eligible; if the confirmatory creatinine clearance is >= 50 mL/min, the patient is eligible; if the cause of the patient’s renal dysfunction is tumor obstructing the ureters, then eligibility can be determined by the study chair even if it does not meet these minimal requirements; for patients < 18 years old, it is strongly suggested that a radioisotope estimation of GFR be obtained; if a radioisotope test is not possible, an estimated creatinine clearance using either a 12 or 24 hour urine creatinine clearance or the Schwartz formula can be used; patients will be considered eligible if the creatinine clearance is > 70 mL/min; if the creatinine clearance estimated by the Schwartz formula or urine creatinine clearance is >= 50 mL/min but =< 70 mL/min, then a second method to confirm a creatinine clearance of >= 50 mL/min is required; methods of estimating GFR that can be used for this confirmation consist of a 12- or 24-hour urine creatinine clearance if the Schwartz formula or radioisotope method was used as the primary method or a radioisotope estimation of GFR if the Schwartz formula or urine creatinine clearance method was used as the primary method; if the confirmatory creatinine clearance is < 50 mL/min, then the patient is not eligible; if the confirmatory creatinine clearance is >= 50 mL/min, the patient is eligible
Serum creatinine clearance >= 30 ml/min
Creatinine clearance >= 30 mL/min
ELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Creatinine clearance of at least 50 mL/min within 7 days prior to first dose of study agent
ELIGIBILITY CRITERIA - PHASE II (ARM D): Creatinine clearance of at least 50 mL/min within 7 days prior to first dose of study agent
Serum creatinine > 1.5 x ULN and/or creatinine clearance ? 50 mL/min
Creatinine clearance < 40 mL/min
Creatinine clearance > 50mL/min
Creatinine clearance =< 50 mL/min
Creatinine =< 1.5 x ULN or creatinine clearance > 60 ml/min
Creatinine clearance ? 40 mL/min (see Section 7.2.1 for instructions regarding calculation of creatinine clearance) performed within 28 days prior to randomization.
Obtained =< 2 weeks prior to registration: Creatinine clearance >= 50 mL/min
Creatinine clearance >= 60 mL/min/1.73 m^2
Within 28 days of study registration: Normal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2
Creatinine clearance ? 50 mL/min
Serum creatinine ? 1.5 X ULN (OR creatinine clearance ? 60 mL/min/1.73 m2)
Serum creatinine =< 1.5 x institution’s ULN, or creatinine clearance >= 30 ml/min
Creatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/min
Serum creatinine clearance >= 15 mL/min (performed within 14 days of treatment initiation)
Creatinine clearance >= 60 mL/min/1.73 m^2
Adequate organ function within 14 days of study registration including:\r\n* Normal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2
Estimated creatinine clearance >= 45 ml/min
Creatinine within 2 times normal institutional limits OR creatinine clearance >= 30 mL/min/1.73 m^2; Note, dose adjustments are required for creatinine clearance (CrCl) >= 30 mL/min but =< 60 ml/min
Creatinine clearance ?60 mL/min
Serum creatinine >1.5 x ULN and/or measured creatinine clearance < 40 ml/min
Creatinine =< 1.5 or creatinine clearance >= 60 ml/ml
Creatinine clearance >= 40 mL/min
Estimated creatinine clearance must be > 40 mL/min
Creatinine clearance < 20 ml/min
Creatinine clearance > 30 mL/min
Creatinine clearance >= 30 mL/min
Creatinine clearance >= 15 ml/min
Creatinine less than 1. 5 X ULN and/or creatinine clearance >= 60 mL/min
Obtained within 21 days prior to cycle 1, day 1: serum creatinine clearance >= 50ml/min
Creatinine: Creatinine clearance > 25 ml/min
Serum Creatinine or Creatinine Clearance** ? 1.5 x ULN, > 50 mL/min
Creatinine clearance 30-75 mL/min
Creatinine clearance ? 50 mL/min
Creatinine clearance > 50 ml/min
Creatinine clearance >= 50 mL/min
Creatinine clearance ? 45ml/min
Creatinine clearance of >= 50 mL/min
Creatinine clearance >= 50 cc/min
Creatinine clearance < 30 ml/min
Creatinine clearance >= 30 ml/min
Within 3 days before the first dose of study drug: creatinine clearance > 50 mL/min
Creatinine clearance >= 50 mL/min.
Subjects with severe renal impairment (i.e., creatinine clearance =< 30 mL/min)
Creatinine clearance >= 40 mL/min/1.73 m^2
Creatinine clearance >= 60 mL/min/1.73 m^2
For Arm G, subjects must have an estimated creatinine clearance >= 50 ml/min.
Serum creatinine clearance >= 30 mL/min
Creatinine clearance >= 60 mL/min/1.73 m^2 unless reduced creatinine clearance felt by investigator to be acute and reversible
Creatinine clearance < 30 ml/min
Creatinine clearance >= 50 ml/min
Serum creatinine clearance >= 30 mL/min
Renal: Serum creatinine 1.5 x ULN or creatinine clearance 60 mL/min.
Creatinine clearance >= 60 mL/min/1.73 m^2 by Cockcoft-Gault
Creatinine clearance ? 50 ml/min
Creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min/1.73 m^2
Cabazitaxel: Creatinine clearance >= 30 mL/min/1.73 m^2
Creatinine clearance of >= 60 ml/min
Creatinine clearance >= 15 mL/min
Estimated creatinine clearance >=60mL/min/1.73 square meter (m^2)
Serum creatinine ? 2.0 x ULN or calculated creatinine clearance ? 45 mL/min based on the Cockroft-Gault GFR estimation. For newly diagnosed AML patients < 75 years of age, creatinine clearance ? 30 mL/min; for ? 75 years of age, creatinine clearance ? 45 mL/min.
Creatinine =< 2.0 mg/dL (adults) and creatinine clearance > 40 mL/min (pediatrics); adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/min/1.73m^2
Estimated creatinine clearance > 45 ml/min
Estimated creatinine clearance > 40 mL/min (this must be checked twice before initiating therapy)
Creatinine clearance < 30 mL/min
Serum creatinine > 1.5 x ULN for age or creatinine clearance =< 60 mL/min/1.73 m^2
Creatinine clearance > 25 ml/min
Estimated or measured creatinine clearance > 50 mL/min
Creatinine clearance greater than 30 ml/min
Serum creatinine clearance >= 30 ml/min
Adequate kidney function with serum creatinine <2 x the ULN or creatinine clearance >30 mL/min
Serum creatinine ? 1.5 x ULN or estimated creatinine clearance ? 60 mL/min
Creatinine clearance >= to 50 ml/min
Serum creatinine =< 1.5 X ULN (OR creatinine clearance >= 60 mL/min/1.73 m^2)
Creatinine clearance < 30 ml/min which cannot be attributed to MCC metastasis
Creatinine clearance of >= 60 mL/min
Serum creatinine =< 2.5 or estimated creatinine clearance >= 30 ml/min and not dialysis-dependent
Creatinine (Cr) clearance >= 30 mL/min
Creatinine clearance >= 45 mL/min
Estimated creatinine clearance must be > 40 mL/min
Creatinine clearance of < 50 ml/min
Estimated creatinine clearance < 15 mL/min
Creatinine clearance >= 30 mL/minutes
Creatinine clearance (Clcr) > 25 mL/min
Creatinine clearance < 30 ml/min
Estimated creatinine clearance >= 50 mL/min
Creatinine clearance >= 30 mL/min/1.73 m^2
Creatinine clearance < 50 mL/min/1.73m^2
Estimated creatinine clearance at least 50 ml/min
Creatinine clearance > 50 ml/min/1.73 m^2 (Schwartz formula)
Relapsed/refractory MCL: Creatinine (Cr) clearance >= 30 mL/min
Newly diagnosed MCL: Creatinine (Cr) Clearance >= 30 mL/min
Creatinine clearance >= 50 ml/min/1.73m^2
Creatinine clearance of >= 60 mL/min
Creatinine clearance equal to or more than 50 mL/min
Creatinine clearance of >= 60 mL/min
Creatinine clearance of >= 60 ml/min
Creatinine clearance > 60 ml/min
Patients with renal insufficiency or creatinine (cr) clearance < 60 ml/min
Creatinine =< 1.5 or creatinine clearance >= 60 ml/min
Estimated creatinine clearance >= 50 ml/min
Adequate renal function defined as creatinine =< 2.0 mg/dl (adults) or estimated creatinine clearance > 40 ml/min (pediatrics); all adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/min
All adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/min
Creatine clearance >= 40 ml/min
Creatinine < 2.0 (adults) or creatinine clearance > 40 ml/min (pediatrics)
Renal: creatinine =< 2.0 mg/dl (adults) and creatinine clearance > 40 ml/min (pediatrics); adults with a creatinine > 1.2 or a history of renal dysfunction must have estimated creatinine clearance > 40 ml/min
Creatinine clearance >= 50 mL/min (repeat if more than 3 days before the first dose)
Creatinine >1.5 x ULN, or measured creatinine clearance <60 mL/min, OR 24-hour measured urine creatinine clearance <60 mL/min OR calculated creatinine clearance <60mL/min estimated using the Cockcroft-Gault equation:
Creatinine clearance ? 45 cc/min
Creatinine clearance ? 30 mL/min
Within 14 days prior to first dose of study drug treatment: Creatinine clearance >= 50 mL/min
Serum creatinine =< 1.5 × ULN or creatinine clearance >= 50 mL/min/1.73 m^2
Creatinine clearance >= 50 mL/min/1.73 m^2
Creatinine clearance >= 60 mL/min/1.73 m^2
Creatinine clearance >= 50 mL/min
Within 28 days prior to administration of therapy: Creatinine clearance >= 50 mL/min
Creatinine clearance < 50 ml/min
Serum creatinine =< 1.5 × ULN or creatinine clearance >= 50 mL/min
Creatinine clearance >= 40 mL/min/1.73 m^2
Patient with severe renal disease (i.e. creatinine greater than 3 times normal for age; creatinine clearance less than 50 ml/min/1.73m^2)
Creatinine clearance > 30 cc/min
Creatinine =< 1.5 times ULN OR measured creatinine clearance of >= 60 mL/min 1.73 m^2
Creatinine clearance >= 60 mL/min, unless secondary to renal involvement by lymphoma; for creatinine clearance < 50 mL/min due to kidney involvement by tumor
Creatinine clearance within 2 weeks of registration must be at least 60 ml/min
Serum creatinine ? 1.5 x ULN; or a creatinine clearance ?40 mL/min;
Serum creatinine ? 2 x ULN or estimated creatinine clearance ? 50 ml/min.
Estimated creatinine clearance ? 30 mL/min.
Creatinine clearance 30 to 69 mL/min.
Estimated creatinine clearance ? 30 mL/min.
Estimated Creatinine Clearance ?30 mL/min
Creatinine clearance >= 50 mL/min
Creatinine clearance or estimated GFR . 60 mL/min/1.73m2
Renal: Creatinine clearance ?50mL/min;
Creatinine clearance inferior to 30 mL per min (MDRD Formula).
Creatinine clearance >=50 milliliter per minutes (mL/min).
Estimated Creatinine Clearance ?30 mL/min
For patients who have creatinine clearance that meets > 50 ml/min they must not have received prior systemic doxorubicin
Creatinine clearance > 50 ml/min
Creatinine clearance >= 30 mL/min
Measured creatinine clearance > 50 ml/min or estimated creatinine clearance > 50 ml/min
Creatinine clearance >= 30 mL/min
Serum Creatinine or Creatinine Clearance** ? 1.5 x ULN, > 50 mL/min
Creatinine clearance ? 60 cc/min
Creatinine =< 1.5 x ULN or creatinine clearance >= 60 mL/min/1.73 m^2
Estimated creatinine clearance >= 30ml/min
Creatinine clearance >= 40 mL/min
Renal: Estimated or measured creatinine clearance >= 60 mL/min.
Subject has severe renal impairment (creatinine clearance < 30 ml/min).
Creatinine clearance >= 45 mL/min
Pediatric patients must have creatinine clearance >= 60 mL/min/1.73 m^2 regardless of serum creatinine level
Creatinine (Cr) clearance >= 30 mL/min
Creatinine clearance > 30 ml/min
Creatinine =< 1.5 times ULN OR measured creatinine clearance > 60 mL/min
Creatinine clearance < 50 mL/min
Creatinine clearance of >= 60 ml/min
Creatinine clearance >= 50 mL/min
Creatinine clearance ? 60mL/min
Creatinine (Cr) clearance >= 60 mL/min
Normal serum creatinine or creatinine clearance >= 60 ml/min/1.73 m^2
Estimated creatinine clearance of >= 40 ml/min
Creatinine Clearance of ? 50 mL/min
Creatinine clearance: the standard Cockcroft and Gault formula must be used to calculate creatinine clearance (CrCl) for enrollment or dosing; also include in the pre-treatment or baseline text portion of the protocol, the 'On Study Evaluations or During Treatment' for every pemetrexed treatment day, and also capture in the study Schedule of Events; no dosage adjustment is needed in patients with creatinine clearance > 45 mL/min; insufficient numbers of patients have been studied with creatinine clearance < 45 mL/min to give a dose recommendation; therefore, pemetrexed should not be administered to patients whose creatinine clearance is < 45 mL/min
Creatinine clearance >= 50 mL/min
creatinine clearance of < 30 mL/min
Creatinine clearance of > 60 ml/min
Estimated creatinine clearance < 50 ml/min
Renal insufficiency of creatinine clearance <40mL/min
Creatinine clearance estimated to be >= 30 ml/min
Creatinine clearance < 40 ml/min
Patients must have either (a) normal kidney function (i.e. creatinine =< 1.5 X upper limit of normal [ULN] OR calculated creatinine clearance >= 60 mL/min by the modified Cockcroft and Gault Formula OR a creatinine clearance >= 60 mL/min obtained from a 24-hour urine collection) or (b) moderate or severe renal dysfunction (i.e. creatinine clearance < 60 mL/min and >= 20 mL/min)
Creatinine clearance (Clcr) > 25 mL/min
Creatinine clearance >= 40 ml/min
creatinine clearance < 70 mL/min, or
Estimated creatinine clearance (CLcr) > 25 ml/min
Creatinine clearance of >= 60 ml/min
Creatinine =< 2.0 X ULN OR creatinine clearance >= 30 mL/min/1.73 m^2
Creatinine clearance >= 60 ml/mm
Creatinine clearance >= 30 ml/min
Creatinine clearance > 30 mL/min
Serum creatinine < 2 x ULN or creatinine clearance > 60 mL/min
Serum creatinine =< 1.5 X ULN and stable X 1 month OR creatinine clearance >= 60 Ml/min/1.73 m^2
Creatinine clearance >= 30 mL/min
Serum creatinine >1.5 x ULN or creatinine clearance ? 45 mL/min
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min
Creatinine Clearance ? 50 ml/min
Creatinine clearance < 30 ml/min which cannot be attributed to MCC metastasis
Patients with creatinine clearance: < 50 mL/min are excluded from this protocol; capecitabine is contraindicated in severe renal impairment (clearance < 40 mL/min)
Creatinine clearance ? 30 mL/min
Creatinine clearance > 50 ml/min
Creatinine clearance must be > 60ml/min
Creatinine clearance >= 40mL/min
Creatinine clearance >= 50 ml/min
Severe renal impairment (creatinine clearance =< 30 ml/min)
Serum creatinine =< 1.5 x ULN or creatinine clearance >= 50 mL/min
Creatinine ?2.0 x ULN or Creatinine Clearance ?40 mL/min
Creatinine clearance ? 50 mL/min
Serum creatinine =< 1.5 x ULN and creatinine clearance > 30 ml/min
Creatinine clearance > 40 ml/min
Serum Creatinine ? 1.5 x ULN, or Creatinine Clearance > 45mL/min
Creatinine clearance >= 50 cc/min
Estimated creatinine clearance of ?40 mL/min
Creatinine clearance >= 50 mL/min
Measured creatinine clearance >= 60 mL/min
Creatinine clearance >= 40 mL/min
Creatinine Clearance < 45 mL/min
Subjects with creatinine clearance ?10 mL/min who are not being treated with continuous renal replacement therapy (CRRT).
Patients must have a serum creatinine within normal limits, or an estimated or measured creatinine clearance >= 65 ml/min
Total Cumulative Illness Rating Scale (CIRS) > 6 and/or creatinine clearance < 70 ml/min
Estimated serum creatinine clearance > 60 ml/min
Creatinine clearance of > 40 ml/min/1.73m^2
Creatinine clearance >= 25 mL/min
Creatinine clearance >= 30 mL/min
Must have a serum creatinine < 2.0 and creatinine clearance > 30 ml/min/m^2; other organ dysfunction is eligible at the discretion of the Principal Investigator (PI)
Patients with a creatinine clearance of < 60 ml/min
Patients with severe renal insufficiency, defined and confirmed by an estimated creatinine clearance equal or lower than 30 mL/min, per institutional laboratory.
Patients with severe renal impairment defined as creatinine clearance of 15-29 mL/min and/or diagnosed with stage 4 chronic kidney disease
Moderate to severe renal failure (creatinine clearance [Clcr] < 30 mL/min)
Patients with a creatinine clearance < 30 mL/min
Acute or chronic renal insufficiency with creatinine clearance < 30 mL/min, drawn within 28 days of consent
Creatinine clearance >= 50 ml/min
Estimated creatinine clearance ? 50ml/min
Creatinine clearance >= 30 mL/min
Estimated creatinine clearance >= 30 ml/min
Patients with creatinine clearance of less than or equal to 50 ml/min
Creatinine clearance ? 30 mL/min
Creatinine =< 1.5, or creatinine clearance >= 45 mL/min
known renal insufficiency with estimated creatinine clearance (eGRF) of less than 54 mL/min;
Creatinine clearance >= 50 cc/min
Estimated creatinine clearance >= 60 ml/min
Significant renal disease as defined by creatinine clearance less than 30 mL/min
Creatinine clearance >= 50 cc/min
Creatinine clearance >= 30 mL/min
Estimated serum creatinine clearance of ? 50 mL/min
Age-adjusted normal serum creatinine or a creatinine clearance ? 40 ml/min
Creatinine > 1.5 x ULN or creatinine clearance < 60 mL/min from assays obtained < 2 weeks prior to study enrollment
Creatinine > 1.5 x ULN or creatinine clearance < 60 mL/min, from assays obtained < 2 weeks prior to study enrollment
Creatinine >1.5 x ULN or creatinine clearance < 60 mL/min
Creatinine > 1.5 x ULN or creatinine clearance < 60 mL/min
Creatinine > 1.5 x ULN or creatinine clearance < 60 mL/min, from assays obtained < 2 weeks prior to study enrollment
Severe renal impairment (i.e. creatinine clearance < 40 mL/min)
Estimated creatinine clearance < 50 mL/min
Serum creatinine >2.0 x ULN, or estimated creatinine clearance <40mL/min