History of allergic reactions attributed to compounds of similar chemical or biologic composition to tremelimumab and MEDI4736 or previous toxicity attributed to MEDI4736 or other PD-1 or PD-L1 directed therapy that led to drug discontinuation History of allergic reaction attributed to compounds of similar chemical or biologic composition to the MEK inhibitor, trametinib Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel and/or both platinum-based chemotherapy agents are excluded; patient must be able to receive at least one of the two proposed chemotherapy regimens History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib, cediranib or bevacizumab Patients with a history of allergic reactions attributed to compounds of similar composition, including macrolide and ketolide antibiotics, temsirolimus/other mTOR inhibitors, temozolomide or irinotecan are not eligible Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to LY2606368 or to its formulation are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib and ramucirumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs (e.g. cisplatin) History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab Patients must NOT have a history of allergic reactions attributed to compounds of similar chemical or biochemical composition to cisplatin, carboplatin, etoposide, temozolomide or capecitabine History of allergic reactions attributed to compounds of chemical or biologic composition similar to palbociclib. History of allergic reactions attributed to compounds of similar chemical or biologic composition to brentuximab vedotin History of allergic reactions attributed to compounds of similar chemical or biologic composition to hetIL-15. Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to phenelzine or other monoamine oxidase inhibitors History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib or trastuzumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, decitabine or SGI-110 History of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to GM-CSF History of allergic reactions attributed to compounds of similar chemical or biologic composition to sotatercept, lenalidomide, pomalidomide, or dexamethasone Patients who have any history of allergic reaction(s) attributed to compounds of similar composition to temozolomide, pazopanib, their metabolites, or any component of their formulation are NOT eligible for participation History of allergic reactions attributed to compounds of similar chemical or biologic composition to eribulin History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab and trebananib including history of allergic reactions to bacterially produced proteins Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PT2385 are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to bavituximab Patients with history of allergic reactions attributed to compounds of similar composition to pazopanib, irinotecan, or temozolomide are not eligible Patients may not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib (including abemaciclib) Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, everolimus or exemestane History of allergic reactions attributed to compounds of similar chemical or biologic composition to ramucirumab Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib are not eligible; AND/OR patients who have had prior exposure to compounds of similar chemical or biologic composition to palbociclib are not eligible hypersensitivity to any component of palbociclib are not eligible for participation History of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to ribociclib, T-DM1 (Cohort A)) and/or trastuzumab (Cohorts B and C) and/or fulvestrant (Cohort C) History of allergic reactions attributed to compounds of similar chemical or biologic composition to PLX3397 or sirolimus A history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel or carboplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-P. History of allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of clinically significant allergic reactions attributed to compounds of similar chemical or biologic composition to AT13387 or paclitaxel History of allergic reactions/hypersensitivity attributed to compounds of similar chemical or biologic composition to tamoxifen, anastrozole, or fulvestrant or any of their ingredients History of allergic reactions attributed to compounds of similar chemical or biologic composition to everolimus History of allergic reactions or hypersensitivity to compounds of similar chemical or biologic composition to anastrozole or letrozole History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax, dabrafenib, or trametinib, or excipients or to dimethyl sulfoxide (DMSO) Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to brentuximab vedotin and/or rituximab Known allergy to any of the study agents or to compounds of similar chemical or biologic composition are excluded (including other somatostatin analogs) History of allergic reactions or adverse reactions (e.g., wound dehiscence) attributed to compounds of similar chemical or biologic composition to PLG or known hypersensitivity to GM-CSF, CPG or PLG Known history of allergic reactions attributed to compounds of similar chemical or biologic composition to fenretinide, such as 13-cis-retinoic acid, retinol, or all-trans-retinoic acid History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib or LY3300054. Subjects with a history of hypersensitivity to compounds of similar biologic composition to atezolizumab or any constituent of the product History of allergic reactions attributed to compounds of similar chemical or biologic composition to MCS110, dabrafenib, or trametinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ipilimumab or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to BVD-523 Subjects with a history of hypersensitivity to compounds of similar biologic composition to atezolizumab or any constituent of the product History of allergic reactions attributed to compounds, or any of its excipients, of similar chemical or biologic composition to osimertinib or selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to abemaciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to daratumumab Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab Women with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to Tamoxifen. EXPANDED ACCESS COHORT: History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib or binimetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cyclophosphamide (only for arm B) History of allergic reactions attributed to compounds of similar chemical composition to SY-1365 History of allergic reactions attributed to compounds of similar chemical or biologic composition to gefitinib or osimertinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to LY3022855, vemurafenib, or cobimetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to apalutamide or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab or previous toxicity attributed to pembrolizumab or other PD-1 directed therapy that led to permanent drug discontinuation History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD1775 or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970 or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib (XL184) History of allergic reactions attributed to compounds of similar chemical or biologic composition to M6620 (VX-970) or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to AT13387 (onalespib) Patents with history of hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to platinum based chemotherapy History of allergic reactions attributed to compounds of similar chemical or biologic composition to vemurafenib History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine or IMGN853 History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or venetoclax Known hypersensitivity to MK-3475 (pembrolizumab) or history of allergic reactions to compounds of similar chemical or biologic composition to anti-PD1 or PD-L1 antibodies or entinostat Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to HMAs History of allergic reactions attributed to compounds of similar chemical or biologic composition to merestinib Participant has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to ACTOplus Met XR History of allergic reactions attributed to compounds of similar chemical or biologic composition to ixazomib or lenalidomide Participant with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids History of allergic reactions attributed to compounds of similar chemical or biologic composition to prexasertib. Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab are not eligible Subject has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PROSTVAC or ipilimumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to sertraline Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib or everolimus History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC102 or TMZ History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine or docetaxel Known hypersensitivity or allergic reactions attributed to any compounds of similar chemical or biologic composition to the study medication, such as recombinant IL-12 or other monoclonal antibodies History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, anetumab ravtansine or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to MTX110 or gadolinium. History of allergic reactions attributed to compounds of similar chemical or biologic composition to rucaparib, mirvetuximab soravtansine or monoclonal antibodies History of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to olaparib or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to any in the regimen Hypersensitivity to chemotherapy or history of allergic reactions attributed to compounds of similar chemical or biologic composition to rituximab, ibrutinib, ICE, Ave, or Uto History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC201 or its excipients. History of significant allergic reactions attributed to compounds of similar composition to SD-101 or BMS-986178 History of allergic reactions attributed to compounds of similar chemical or biologic composition to apatinib or pembrolizumab A history of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, cisplatin (for cohort 1), or cetuximab (for cohort 2) History of allergic reactions attributed to compounds of similar chemical or biologic composition to any of the agents on this trial History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study vaccine components and any of the chemotherapy drugs (docetaxel, carboplatin, trastuzumab, pertuzumab) History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to anti-LAG-3, anti-CD137, and anti-PD1 are ineligible; the investigator brochures can be referenced for more information History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244 History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study agent or accompanying supportive medications. The patient has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC201 or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to EGF816 or gefitinib Subjects with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to IACS-010759. History of known immediate or delayed hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to INCB039110, dabrafenib, or trametinib, or excipients or to dimethyl sulfoxide (DMSO). History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab unless felt to be in the best interests of the patient in the opinion of the investigator Patient must not have a history of allergic reactions like anaphylaxis attributed to compounds of similar chemical or biologic composition to meclizine such as antihistamine drugs. History of allergic reactions attributed to compounds of similar chemical or biologic composition to fostamatinib or paclitaxel; patients who are able to tolerate paclitaxel on a desensitization protocol will be allowed History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab or mifepristone History of clinically significant allergic reactions attributed to compounds of similar chemical or biologic composition to AZD8186 or docetaxel or to docetaxel itself Patients with a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or T-DM1 History of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel or carboplatin Known severe hypersensitivity to selumetinib or olaparib, their comparators, or combination medications or any excipient of these medicinal products, or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib or olaparib, or their comparator History of allergic reactions attributed to compounds of similar chemical or biologic composition to topotecan, other topoisomerase inhibitors or gadolinium compounds Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to HMAs History of allergic reactions attributed to compounds of similar chemical or biologic composition to lamivudine History of allergic reactions attributed to compounds of similar chemical or biologic composition to zydelig History of allergic reactions attributed to compounds of similar chemical or biological composition to cetuximab (anti-EGFR). History of allergic reactions attributed to compounds of similar chemical or biologic composition to anetumab ravtansine or MK-3475 (pembrolizumab) History of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel including to other drugs formulated in cremophor(R) EL (polyoxyethylated castor oil) History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, topotecan, gadolinium, or lipids Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide are not eligible Known hypersensitivity to poziotinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to poziotinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to mistletoe History of allergic reactions attributed to compounds of similar chemical or biologic composition to 90Y-DOTA-tyr3-octreotide, Octreoscan, 68Ga-octreotide, or 131I-MIBG History of allergic reactions attributed to compounds of similar chemical or biologic composition to clarithromycin or taxanes History of allergic reactions attributed to compounds of similar chemical or biologic composition to CDX-1127 (varlilumab) and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to HCQ History of allergic reactions attributed to compounds of chemical or biologic composition similar to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib or abiraterone History of allergic reactions attributed to compounds of similar chemical or biologic composition to TRC102 or pemetrexed and cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab are not eligible; known hypersensitivity to any excipients of pembrolizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to hydroxychloroquine or received HCQ in the past six months History of allergic reactions attributed to compounds of similar chemical or biologic composition to fosbretabulin Hypersensitivity to BV or history of allergic reaction attributed to compounds of similar chemical or biologic composition of BV History of allergic reactions attributed to compounds of similar chemical or biologic composition to pevonedistat or decitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to IL-2 History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin Known hypersensitivity to compounds of similar chemical composition to BMX-001 Known allergy to compounds of similar chemical or biologic composition to nivolumab Has a history of allergic reactions attributed to the study treatments (AZD9150 or MEDI4736), their compounds, or agents of similar chemical or biologic composition (eg, antibody therapeutics) History of allergic reactions attributed to compounds of similar chemical or biologic composition to TVB-2640 History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide and/or TG02 History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or indomethacin History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab, cisplatin, carboplatin, or etoposide Patients with known allergy to eggs or to compounds with a similar chemical or biologic composition to PROSTVAC or nivolumab History of allergic reactions attributed to compounds of similar composition to SD-101 or ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to daunorubicin History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib, carboplatin or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to durvalumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine or talazoparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab including any history of severe allergic reactions to monoclonal antibody therapy Patients with a history of allergic reactions attributed to or intolerance to compounds of similar chemical or biologic composition to either CB-839 or capecitabine; if capecitabine has been received previously, must have tolerated at least an equivalent dose to the dose to be administered at their assigned dose level Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin and pemetrexed History of allergic reactions attributed to compounds of similar chemical or biologic composition to selinexor History of allergic reactions attributed to compounds of similar chemical or biologic composition to blinatumomab Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab are not eligible AND/OR patients who have had prior exposure to compounds of similar chemical or biologic composition to pembrolizumab are not eligible Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to BCG are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to abiraterone or PDMX1001/niclosamide Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI3475 are not eligible History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to lenvatinib and/or paclitaxel History of allergic reactions attributed to fluorouracil (5-FU), leucovorin, irinotecan or oxaliplatin or to compounds of similar chemical or biologic composition History of allergic reaction to compounds of similar chemical or biologic composition to cytarabine Known hypersensitivity or history of allergic reactions attributed to compounds of similar chemical or biologic composition to IRX5183 A history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib and brentuximab vedotin (BV) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ramucirumab or nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib Known allergy to compounds of similar chemical or biologic composition to nivolumab A history of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib, temozolomide, or dacarbazine History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) A history of allergic reaction attributed to compounds of similar chemical or biologic composition to fluorouracil (5FU), oxaliplatin, or leucovorin History of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib or bortezomib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab, paclitaxel or carboplatin Subjects with a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to DS3032b History of allergic reactions attributed to compounds of similar chemical or biologic composition to methoxyamine or to pemetrexed or cisplatin History of allergic reactions, intolerance or hypersensitivity attributed to compounds of similar chemical or biologic composition to TRC105 and/or everolimus or other rapamycin analogs (e.g. sirolimus, temsirolimus) History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI-570 or history of anaphylaxis to any biological component History of allergic reactions attributed to compounds of similar chemical or biologic composition to leflunomide or cholestyramine PHASE I STUDY ELIGIBILITY CRITERIA:\r\nHistory of allergic reactions attributed to compounds of similar chemical or biologic composition to MEDI4736, olaparib, cediranib, or to other humanized monoclonal antibodies; known history of anaphylaxis, angioedema, laryngeal edema, serum sickness, or uncontrolled asthma History of allergic reaction attributed to compound(s) of similar chemical or biologic composition as ARQ 092, carboplatin, paclitaxel, or anastrozole History of allergic reactions attributed to compounds of similar chemical or biologic composition to talimogene laherparepvec History of allergic reactions attributed to compounds of similar chemical or biologic composition to any in the pre- or post-transplant regimen History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to pemetrexed Patients with history of allergic reactions attributed to compounds of similar chemical; or biologic composition to vorinostat or temsirolimus are not eligible History of hypersensitivity reaction specifically attributed to compounds of similar chemical or biologic composition to 5-FU, leucovorin, capecitabine or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR Prior allergic reactions attributed to compounds of similar chemical or biologic composition to dabrafenib or trametinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to basiliximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or metformin History of allergic reactions attributed to compounds of similar chemical or biologic composition to GDC-0449 History of allergic reactions attributed to compounds of similar chemical or biologic composition to VOR or HCQ History of allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC201 or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) or ziv-aflibercept A history of allergic reactions attributed to compounds of similar chemical or biologic composition to docetaxel or carboplatin History of known immediate or delayed hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to AT13387, dabrafenib, or trametinib, or excipients or to dimethyl sulfoxide (DMSO) History of allergic reactions attributed to compounds of similar chemical or biologic composition to etoposide History of allergic reactions attributed to compounds of similar biologic composition to M032 or to IL-12 History of allergic reactions attributed to compounds of similar chemical or biologic composition to propranolol History of allergic reactions to compounds of similar composition to either CDX-301 or poly-ICLC History of prior allergic reactions attributed to compounds of similar chemical or biologic composition as capecitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to 5-fluorouracil, oxaliplatin, irinotecan or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, docetaxel, vorinostat, or granulocyte colony-stimulating factor (G-CSF) History of allergic reactions attributed to compounds of similar chemical or biologic composition to melphalan History of allergic reactions attributed to compounds of similar chemical or biologic composition to DOPC, Magnevist, or fluorodeoxyglucose (FDG) History of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin for patients who will receive chemotherapy History of allergic reactions attributed to compounds of similar chemical or biologic composition to IPdR History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD9291 (osimertinib) or bevacizumab No history of allergic reactions attributed to compounds of similar chemical or biologic composition to cisplatin, lomustine, vincristine (vincristine sulfate) or cyclophosphamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin EXCLUSION CRITERIA FOR REGISTRATION: history of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin History of allergic reactions attributed to compounds of similar chemical or biological composition to Valproic Acid History of allergic reactions attributed to compounds of similar chemical or biologic composition to tremelimumab and durvalumab or previous toxicity attributed to durvalumab or other PD-1 or PD-L1 directed therapy that led to drug discontinuation History of allergic reactions attributed to compounds of similar chemical or biologic composition to TCN-PM History of allergic reactions to compounds of similar chemical or biologic composition to talactoferrin or the chemotherapy drugs History of allergic reactions attributed to compounds of similar chemical composition to IHL-305 History of allergic reactions attributed to compounds of similar chemical or biologic composition to cenersen. History of allergic reactions attributed to compounds of similar chemical or biologic composition to copanlisib and/or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to CPI-613 or docetaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to tamoxifen History of allergic reactions attributed to compounds of similar chemical or biologic composition to 5-fluorouracil or imiquimod History of allergic reactions attributed to compounds of similar chemical or biologic composition to CPI-613 History of allergic reactions attributed to compounds of similar chemical or biologic composition; History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs; patients who have previously received either clofarabine or bortezomib will be excluded Patients with known hypersensitivity to nintedanib or 5-azacitidine or who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nintedanib or 5-azacitidine are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenvatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to durvalumab or any excipient or any egg products History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or PDMX1001/niclosamide A history of allergic reactions or significant toxicity attributed to compounds of similar chemical or biologic composition to anti-CD20 mAbs, anti-PD-1 mAbs, or TLR agonists. Participants who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to birinapant or its constituents History of allergic reactions attributed to compounds of similar chemical or biologic composition to WP1066 History of allergic reactions attributed to compounds of similar chemical or biologic composition to M6620 (VX970), cisplatin, or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or sorafenib Patients with a history of hypersensitivity or allergic reactions attributed to compounds of similar chemical or biologic composition to AMG 232 are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to nelfinavir History of allergic reactions attributed to compounds of similar chemical or biologic composition to abemaciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to measles virus vaccination History of allergic reactions attributed to compounds of similar chemical or biologic composition to XL184 Subjects with history of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG 232 or carfilzomib, lenalidomide, or dexamethasone Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to BAL101553 are ineligible History of allergic reaction attributed to compounds of similar or biologic composition to inotuzumab ozogamicin or other agents in the study History of allergic reactions attributed to compounds of similar chemical or biologic composition to quinacrine, capecitabine or fluorouracil History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or vistusertib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to tazemetostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to TAS-102 or TMZ History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib, cediranib, carboplatin, cisplatin, or etoposide History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to either paclitaxel or ricolinostat; patients who require administration of paclitaxel through a desensitization procedure are not eligible for this study History of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib and MM-398; if patients have a history of allergic reactions to compounds resembling MM-398, they will be excluded from participating in the FMX MRI study, if applicable History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970, carboplatin, gemcitabine or to these specific compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to triapine or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib (difficulty breathing, lip swelling, itching or rash) History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 and ziv-aflibercept History of allergic reactions attributed to compounds of similar chemical or biologic composition to briciclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to study drugs (e.g. cisplatin, paclitaxel) History of allergic reactions attributed to compounds of similar chemical or biologic composition to carfilzomib or belinostat History of allergic reactions to compounds with similar biologic or chemical composition to pembrolizumab or radium-223 History of allergic reactions attributed to compounds of similar chemical or biologic composition to CDX-1401 or CDX-301 or poly-ICLC History of allergic reactions attributed to compounds of similar chemical or biologic composition to CYT107 History of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to metformin, ritonavir or any of their ingredients Have history of allergic reactions attributed to compounds of similar chemical or biologic composition to taxanes (docetaxel or paclitaxel) or cyclophosphamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to G-CSF/filgrastim (Escherichia [E] coli producing cell line), plerixafor or busulfan History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to Dex or Enza History of allergic reactions attributed to compounds of similar chemical or biologic composition to G-CSF/filgrastim (E. coli producing cell line) and plerixafor History of allergic reactions attributed to compounds of similar chemical or biologic composition to either 5-FU/capecitabine or interferon Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-paclitaxel, gemcitabine or AZD1775 PHASE II: Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to nab-paclitaxel, gemcitabine or AZD1775 History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244 or cyclosporine A or their excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to TPI 287 History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, nab-paclitaxel or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to HDACI, TLR-agonist, or patients with known history of pre-existing auto-immune disease History of allergic reactions attributed to compounds of similar chemical or biologic composition to INCB024360, MELITAC 12.1, or other vaccine components History of allergic reactions attributed to compounds of similar chemical or biologic composition to cetuximab or ipilimumab Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib, bortezomib or decitabine that are not easily managed History of allergic reactions attributed to compounds of similar chemical or biologic composition to PF-04449913 No history of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib, temozolomide and dacarbazine History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to digoxin History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib, erlotinib or gemcitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition (i.e. ethanol) to XL888 or vemurafenib (i.e., ethanol) History of allergic reactions attributed to compounds of similar chemical or biologic composition of decitabine, cytarabine or daunorubicin History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenalidomide (i.e. thalidomide) Poor tolerability or known allergy to any of the study drugs or compounds of similar chemical or biologic composition to lenalidomide, bortezomib and/or dexamethasone Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib and/or cetuximab History of allergic reactions attributed to compounds of similar chemical composition to afatinib Poor tolerability or known allergy to lenalidomide, bortezomib and/or dexamethasone or compounds that have similar chemical or biologic composition to these study drugs History of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib Patient must have no history of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 (pembrolizumab) History of allergic reactions attributed to compounds of similar chemical or biologic composition to VX-970 History of allergic reactions attributed to compounds of similar chemical or biologic composition to M6620 (VX-970) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD1775 or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD 1775 (MK-1775) or gemcitabine History of Grade 3 or 4 allergic reactions attributed to compounds of similar chemical or biologic composition as MSC2363318A Subjects with a history of allergic reactions attributed to compounds of similar composition to dolastatin or auristatin. Compounds of similar composition include Auristatin PHE as an anti-fungal agent, Auristatin PE (TZT-1027, Soblidotin, NSC-654663) as an anti-tumor agent and Symplostatin 1 as an anti-tumor agent. SUB-PROTOCOL AIM A: History of allergic reactions attributed to compounds of similar chemical or biologic composition including macrolide (e.g. azithromycin, clarithromycin, dirithromycin, and erythromycin) and ketolide antibiotics No history of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib, lenalidomide or rituximab or hypersensitivity to murine proteins or to any component of rituximab History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or rapamycin History of allergic reactions attributed to compounds of similar chemical or biologic composition to mitomycin-C or 5-fluorouracil History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat or HCQ History of allergic reactions attributed to compounds of similar chemical or biologic composition to daunorubicin or cytarabine History of allergic reactions attributed to compounds or similar chemical or biological composition to ibrutinib History of allergic reactions attributable to compounds of similar chemical or biologic composition to ibrutinib or any component of pneumococcal, influenza and DTaP vaccines History of allergic reactions attributed to compounds of similar chemical or biologic composition to mocetinostat or brentuximab vedotin History of hypersensitivity or allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, Taxotere, Xeloda, cisplatin, or irinotecan Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine that are not easily managed History of allergic reactions attributed to compounds of similar chemical or biologic composition to hydroxychloroquine History of allergic reactions attributed to compounds of similar chemical or biologic composition to dacomitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib or any of the components of the vaccine being administered as part of this study History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN8237, bortezomib or rituximab History of allergic reactions attributed to compounds of similar chemical or biological composition to metformin or oxaliplatin or fluorouracil (5-FU) History of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG 232 or decitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab; prior hypersensitivity reactions to anti-CD20 therapy or anti-CD30 therapy is not an exclusion criterion History of allergic reaction(s) attributed to compounds of similar chemical or biologic composition to 5-fluorouracil, irinotecan, or oxaliplatin Patients who have a history of allergic reactions or hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to pembrolizumab and/or humanized antibodies are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab or atezolizumab History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab or lenalidomide Patients with a history of allergic reactions attributed to bevacizumab or to compounds of similar chemical or biologic composition to nivolumab or bevacizumab are excluded Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to 177Lu-DOTA-JR11 as assessed from medical records History of allergic reactions attributed to compounds of similar chemical or biologic composition to MGE Subjects with a history of hypersensitivity to compounds of similar biologic composition to tremelimumab or any constituent of the product Subjects with a history of hypersensitivity to compounds of similar biologic composition to durvalumab or any constituent of the product Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 are not eligible; known hypersensitivity to any excipients of MK-3475 Known allergy to any of the treatment components including a history of allergic reactions attributed to compounds of chemical or biological composition similar to olaratumab. History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib and/or bazedoxifene History of allergic reactions attributed to compounds of similar chemical or biologic composition to PM01183 or trabectedin (Yondelis, ET-743) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ONC201 or its excipients History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD9150 Participants may not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab Patient has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to PBI-05204 (i.e., cardiac glycoside compounds). History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN8237, including but not limited to established allergic reaction to benzodiazepines, 5-FU (fluorouracil), leucovorin (leucovorin calcium) or oxaliplatin History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to IL-2 History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab Patient has a history of allergic reactions to compounds of similar chemical or biological composition to buparlisib History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, cetuximab, and/or bevacizumab that led to discontinuation of those agents History of allergic reactions attributed to compounds of similar chemical or biologic composition to elotuzumab or lenalidomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or omega-3 fatty acids Patient has a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 Prior treatment with or allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib Patients must not have a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to perifosine or temsirolimus Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temsirolimus or perifosine History of allergic reactions attributed to compounds of similar chemical or biologic composition to crizotinib or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine and eribulin History of allergic reactions attributed to compounds of similar chemical or biologic composition to X-82, docetaxel, or granulocyte colony stimulating factors History of allergic reactions attributed to compounds of similar chemical or biologic composition to LDE 225 or everolimus in the study or other rapamycin analogs (e.g. sirolimus, temsirolimus) History of severe allergic reactions attributed to compounds of similar chemical or biologic composition to ofatumumab or idelalisib History of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin or docetaxel Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to decitabine that are not easily managed History of allergic reactions or idiosyncrasy attributed to progestins or compounds of similar chemical structure to sodium cridanimod or lidocaine; Research participants with a history of allergic reactions attributed to compounds of similar chemical or biological composition to cetuximab Patients with known grade 2 or greater allergic reactions attributed to compounds of similar chemical or biologic composition to mifepristone, carboplatin, or gemcitabine are ineligible for study enrollment PHASE I: History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib PHASE II: History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabozantinib History of allergic reactions to compounds of similar chemical or biological composition to T DM1 or ONT-380, except for a history of Grade 1 or Grade 2 Infusion Related Reaction to trastuzumab which has been successfully managed. Poor tolerability or known allergy to any of the study drugs or compounds of similar chemical or biologic composition to lenalidomide, bortezomib, panobinostat and/or dexamethasone History of allergic reactions attributed to compounds of similar chemical or biologic composition to trametinib monotherapy or trametinib in combination with GSK2141795 History of allergic reactions attributed to compounds of similar chemical or biologic composition to entinostat, azacitidine, or nivolumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to rucaparib. Participants who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to neratinib or fulvestrant History of allergic reactions attributed to lenalidomide or compounds of similar chemical or biologic composition to lenalidomide including thalidomide PART B: History of allergic or severe reactions attributed to compounds of similar chemical or biologic composition to ponatinib History of grade 3 or 4 allergic reactions attributed to compounds of similar chemical or biologic composition to ARRY-380 or trastuzumab History of allergic reaction attributed to compounds of similar chemical or biologic composition to eribulin mesylate, trastuzumab or pertuzumab, which cannot be managed by premedication History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or lenalidomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to tivozanib or enzalutamide History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to enzalutamide or poxviral vaccines (e.g., vaccinia vaccine) History of allergic reactions attributed to compounds of similar chemical or biologic composition to AUY922 History of allergic reactions attributed to compounds of similar chemical or biologic composition to midostaurin and/or decitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to 5-fluorouricil, irinotecan, oxaliplatin, or losartan History of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel, trastuzumab, pertuzumab; patients with minor (grade 1 or 2) allergic reactions to these agents, controlled with standard supportive measures, are eligible History of allergic reactions attributed to, or intolerance of, or other significant toxicity with, compounds of similar chemical or biologic composition to X-82 or everolimus REGISTRATION EXCLUSION CRITERIA: History of allergic reactions attributed to compounds of similar chemical or biologic composition to trastuzumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab History of allergic reactions attributed to compounds of similar chemical or biological composition as ARQ 087 History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenalidomide (including thalidomide), clarithromycin, or melphalan History of allergic reactions attributed to compounds of similar chemical or biologic composition to FLT Patients must not have any of the following conditions:\r\n* Recent major surgery, hormonal therapy (other than replacement) or chemotherapy, within 4 weeks prior to entering the study or those who have not recovered from the adverse events of treatment\r\n* History of allergic reactions attributed to compounds of similar chemical or biologic composition to the chemotherapy on this trial History of allergic reactions attributed to 5FU, leucovorin, irinotecan or oxaliplatin or to compounds of similar chemical or biologic composition. History of allergic reactions attributed to compounds of similar chemical or biologic composition to dexanabinol History of allergic reactions attributed to compounds of similar chemical or biologic composition to topotecan or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to black cohosh History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to 5-fluorouracil, irinotecan, or oxaliplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ABT-888 or abiraterone History of allergic reactions attributed to compounds of similar chemical or biologic composition to fulvestrant or ganetespib History of allergic reactions attributed to compounds of similar chemical or biologic composition to fluorouracil (5-FU), capecitabine, oxaliplatin, leucovorin, bevacizumab, and/or vitamin D3 History of allergic reactions attributed to compounds of similar chemical or biologic composition to neratinib (or to capecitabine for cohorts 3a/3b) History of allergic reactions attributed to compounds of similar chemical or biologic composition to capecitabine and hydroxychloroquine (HCQ) History of allergy or reaction attributed to compounds of chemical or biologic composition similar to those of MEDI-573 or AI History of allergic reactions attributed to compounds of similar chemical or biologic composition to plerixafor or bevacizumab History of allergic reactions attributed to compounds of similar chemical or biologic composition of BKM120, BYL719, capecitabine (including fluorouracil), trastuzumab or lapatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to AMG 232 History of allergic reactions to palbociclib or attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib maleate or olaparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to PF-00299804 Known or suspected allergy to any recombinant human antibodies, or compounds of similar chemical or biologic composition to sorafenib or any of the drugs in this study History of allergic reactions attributed to compounds of similar chemical or biologic composition to BMN673 (talazoparib) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or idarubicin or cytarabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan, 5-FU, leucovorin or any of the products to be administered during dosing Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to platinums, taxanes or fluoropyrimidines History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD1775 or belinostat History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan or selinexor History of allergic reactions attributed to compounds of similar composition to SD-101 or ipilimumab (anti-cytotoxic T-lymphocyte-associated protein 4 [CTLA4] antibodies) Prior allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine (gemcitabine hydrochloride) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-1775 or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib or clindamycin (topical agent for potential skin toxicity) History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MEK162, anthracycline, or cytarabine History of allergic reactions attributed to compounds of similar chemical or biologic composition to lapatinib Subjects with history of hypersensitivity to compounds of similar chemical or biologic composition of XILONIX™. History of allergic reactions attributed to compounds of similar chemical or biologic composition to peg-IFN?-2b History of allergic reactions attributed to compounds of similar chemical or biologic composition to SS1(dsFv)PE38 ERLOTINIB HYDROCHLORIDE ARM: History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib (erlotinib hydrochloride) SELUMETINIB ARM: History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244 (selumetinib) AKT INHIBITOR MK2206 ARM: History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-2206 (Akt inhibitor MK2206) LAPATINIB DITOSYLATE ARM: History of allergic reactions attributed to compounds of similar chemical or biologic composition to lapatinib SUNITINIB MALATE ARM: History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MPDL3280A, carboplatin, or paclitaxel Patient with history of allergic reactions or hypersensitivity attributed to compounds of similar chemical or biologic composition to enzalutamide, carboplatin, or paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to palbociclib History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib and/or onalespib History of allergic reactions attributed to compounds of similar chemical or biologic composition to onalespib or AT7519M History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) History of allergic reactions attributed to compounds of similar chemical or biologic composition to vorinostat or temsirolimus Patients with history of allergic reactions attributed to compounds of similar chemical or biologic composition to belinostat, including hydroxamate compounds or arginine Patients with a history of allergic reactions attributed to compounds of similar composition to dolastatin or auristatin; compounds of similar composition include auristatin PHE as an anti-fungal agent, auristatin PE (TZT-1027, Soblidotin, NSC-654663) as an anti-tumor agent and symplostatin 1 as an anti-tumor agent History of allergic reactions attributed to compounds of similar chemical or biologic composition to lithium carbonate History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, oxaliplatin, fluorouracil (5-FU), docetaxel, or irinotecan History of allergic reactions attributed to compounds of similar chemical or biologic composition to dinaciclib or to MK-2206 Patients with history of allergic reactions attributed to compounds of similar composition to sirolimus, cyclophosphamide, or topotecan are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin, or nab-paclitaxel History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine (gemcitabine hydrochloride) or cisplatin History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 History of allergic reactions attributed to compounds of similar chemical or biologic composition to ibrutinib or R-ICE History of allergic reactions attributed to compounds of similar chemical or biologic composition to tivozanib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-2206 Known hypersensitivity/history of allergic reactions attributed to compounds of similar chemical or biologic composition to everolimus or fulvestrant. Known hypersensitivity to ipilimumab or history of allergic reactions attributed to compounds of similar chemical or biologic composition to ipilimumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to Cabazitaxel, or to drugs formulated with polysorbate 80. History of allergic reactions attributed to compounds of similar chemical or biologic composition to rituximab History of allergic reactions attributed to compounds of similar chemical or biologic composition as TG02 citrate. History of allergic reactions attributed to compounds of similar chemical or biologic composition to pioglitazone History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib and ipilimumab Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or AZD1775 (MK-1775) are ineligible; the AZD1775 (MK-1775) investigator brochure and the temozolomide package insert can be referenced for more information History of allergic reactions attributed to compounds of similar chemical or biologic composition to dabrafenib and its excipients. Known severe hypersensitivity to selumetinib or any excipient of selumetinib or history of allergic reactions attributed to compounds of similar chemical or biologic composition to selumetinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to panitumumab History of allergic reactions attributed to compounds of similar chemical or biologic composition to ARQ 197 or temsirolimus History of allergic reactions attributed to compounds of similar chemical or biologic composition to vemurafenib or leflunomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN8237, including but not limited to established allergic reaction to benzodiazepines History of allergic reactions attributed to compounds of similar chemical or biologic composition to RAD001 or SOM230 (pasireotide) History of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib or hydroxychloroquine The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to that of cixutumumab or to octreotide History of allergic reactions attributed to compounds of similar chemical or biologic composition to talimogene laherparepvec Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to volasertib or VSLI are not eligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to talazoparib History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab, nab-paclitaxel or temozolomide History of allergic reactions attributed to compounds of similar chemical or biologic composition to donepezil; hypersensitivity to donepezil History of allergic reaction attributed to compounds of similar chemical or biologic composition to paclitaxel, which cannot be managed by premedication Patients must not have a known history of allergic reactions attributed to compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-3475 (pembrolizumab) and interferon-gamma; patients who are hypersensitive to Escherichia (E). coli are also excluded History of allergic reactions attributed to compounds of similar chemical or biologic composition to eribulin mesylate or pembrolizumab History of allergic reactions attributed to tamoxifen or compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to CUDC-907 History of allergic reactions attributed to compounds of similar chemical or biologic composition to apalutamide, abiraterone acetate, or other study drugs Patients who have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to sildenafil or phosphodiesterase-5 (PDE5) inhibitors such as vardenafil (Levitra) and tadalafil (Cialis) are not eligible. History of allergic reactions attributed to compounds of similar chemical or biologic composition to amide local anesthetics, acetaminophen or dexamethasone History of severe (i.e. anaphylactic) allergic reactions attributed to compounds of similar chemical or biologic composition to glucocorticoids and other component of R- History of allergic reactions attributed to compounds of similar chemical or biologic composition to cadaveric component, i.e. Flex HD History of allergic reactions attributed to compounds of similar chemical or biologic composition to carboplatin, paclitaxel not responsive to traditional desensitization procedures History of allergic reactions attributed to compounds of similar chemical or biologic composition to Adriamycin, dacarbazine, or brentuximab History of hypersensitivity attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) or osimertinib (AZD9291) Known sensitivity to or history of allergic reactions attributed to compounds of similar chemical or biologic composition entinostat, nivolumab, or ipilimumab; history of severe hypersensitivity reaction to any monoclonal antibody History of allergic reactions attributed to compounds of similar chemical or biologic composition to naltrexone No investigational agent, so no exclusion requirements regarding history of allergic reactions attributed to compounds of similar chemical or biologic composition to investigational agent or device Patient must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to lithium carbonate History of allergic reactions attributed to compounds of similar chemical or biologic composition to ruxolitinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib History of allergic reactions to yeast or attributed to compounds of similar chemical or biologic composition to Gardasil 9 HPV vaccine History of allergic reactions attributed to compounds of similar chemical or biologic composition to exemestane History of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib (Tarceva) History of allergic reactions attributed to compounds of similar chemical or biologic composition to 4-OHT gel History of allergic reactions attributed to compounds of similar chemical or biologic composition to INO-8000 and INO-9012 History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to simvastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical or biologic composition to NeuVax History of allergic reaction to zileuton or attributed to compounds of similar chemical or biologic composition to zileuton History of allergic reactions attributed to compounds of similar chemical or biologic composition to MUC1/Poly?ICLC History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to simvastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical or biologic composition to WOKVAC History of allergic reactions attributed to compounds of similar chemical or biologic composition to Avmacol History of allergic reactions attributed to compounds of similar chemical or biologic composition to bexarotene gel, oral or topical retinoids History of allergic reactions attributed to compounds of similar chemical or biologic composition to Gardasil or Gardasil 9 History of allergic reactions or intolerance attributed to aspirin or compounds of similar chemical or biologic composition History of allergic reactions attributed to compounds of similar chemical or biologic composition to green tea or EGCG History of allergic reactions attributed to compounds of similar chemical or biologic composition to Meriva Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of alendronate and other bisphosphonates Documented history of allergic reactions attributed to compounds of similar chemical or biologic composition to buproprion History of allergic reactions attributed to compounds of similar chemical or biologic composition to aspirin Participants must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition of iloprost History of adverse effects, intolerance, or allergic reactions attributed to compounds of similar chemical or biologic composition to pravastatin (i.e., other statin medications) History of allergic reactions attributed to compounds of similar chemical composition to Polyphenon E (or green tea), or intravenous contrast that is required for CT scan History of allergic reactions attributed to compounds of similar chemical or biologic composition of PROSTVAC Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to berberine will be excluded History of allergic reactions attributed to compounds of similar chemical composition to metformin or prior use of metformin within the last year History of allergic reactions attributed to compounds of similar chemical or biologic composition to telapristone (i.e. other progesterone antagonists) History of allergic reactions attributed to compounds of similar chemical or biologic composition to PFE A history of allergic reactions attributed to compounds of similar chemical or biologic composition to tamoxifen History of allergic reactions attributed to compounds of similar chemical or biologic composition to Polyphenon E, tea, or any of the inactive ingredients present in the active or placebo drug products, including gelatin capsules History of allergic reactions attributed to compounds of similar chemical composition to YF476 History of allergic reactions attributed to compounds of similar chemical or biologic composition of GARDASIL 9 (recombinant human papillomavirus nonavalent vaccine), including yeast allergy History of allergic reactions attributed to aspirin or compounds of similar chemical or biologic composition to the study agent History of allergic reactions attributed to compounds of similar chemical or biological composition to aspirin, NSAIDs, cyclooxygenase-2 (COX2) inhibitors History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study agent History of allergic reactions attributed to compounds of similar chemical or biologic composition to cabazitaxel or other drugs formulated with polysorbate 80; or abiraterone acetate Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN0128 (TAK-228) are ineligible History of allergic reactions attributed to compounds of similar chemical or biologic composition to romidepsin, including cyclic tetrapeptide compounds History of allergic reactions attributed to compounds of similar chemical or biologic composition to DHA or corn/soy oil in placebo agent History of allergic reactions attributed to compounds of similar chemical or biologic composition to linaclotide Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids Patient must NOT have a history of allergic reaction attributable to compounds of similar chemical or biologic composition to 18F-FES Patient must NOT have a history of allergic reaction attributable to compounds of similar chemical or biologic composition to 18F-fluorothymidine History of allergic reactions attributed to compounds of similar chemical or biologic composition to PBR History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or FMISO Patients with known allergic or hypersensitivity reactions to previously administered radiopharmaceuticals of similar chemical or biologic composition to FLT or FDG are NOT eligible Patients with a history of allergic reaction attributable to compounds of similar chemical or biologic composition to FFNP Patients with known allergic or hypersensitivity reactions to previously administered radiopharmaceuticals of similar chemical or biologic composition to FES are NOT eligible. History of allergic reactions attributed to compounds of similar chemical or biologic composition to demeclocycline SURGICAL ARM: history of allergic reactions attributed to compounds of similar chemical or biologic composition to tetracyclines History of allergic reactions attributed to compounds of similar chemical or biologic composition to copper Cu 64 anti-CEA monoclonal antibody M5A (64Cu-M5A) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ferumoxytol History of allergic reactions attributed to compounds of similar chemical or biologic composition to magnetic resonance (MR) contrast material History of allergic reactions attributed to compounds of similar chemical or biologic composition to indocyanine green, including those patients with a history of iodide or seafood allergy History of allergic reactions attributed to compounds of similar chemical or biologic composition to indocyanine green, including those patients with a history of iodide or seafood allergy History of allergic reactions attributed to compounds of similar chemical or biologic composition to FDHT History of allergic reactions attributed to compounds of similar chemical or biologic composition to L-[methyl-11C]methionine History of allergic reactions attributed to compounds of similar chemical or biologic composition to lorlatinib History of allergic reactions attributed to compounds of similar chemical or biologic composition to aminolevulinic acid (ALA) History of allergic reactions attributed to compounds of similar chemical or biologic composition to ALA; patients should refrain from use of other potential phototoxic substances (e.g. tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts) for 72 h History of allergic reactions attributed to compounds of similar chemical or biologic composition to Eovist History of allergic reactions to compounds of similar chemical composition to ALA History of allergic reactions attributed to compounds of similar chemical or biologic composition to vitamin D History of allergic reactions attributed to compounds of similar chemical or biologic composition to idelalisib The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab or cisplatin. The participant has a history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab or carboplatin. History of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab, ipilimumab, or blinatumomab History of allergic reactions/hypersensitivity attributed to compounds of similar chemical or biologic composition to CE/BZA; (I.e. same class of drug as CE/BZA) History of allergic reactions attributed to compounds of similar chemical or biologic composition to cetuximab.