Known hypersensitivity to any component of bevacizumab Patients must not have any known allergy or reaction to any component of the durvalumab (MEDI4736) and/or tremelimumab formulation Known hypersensitivity to any component of the formulation or substituted benzimidazoles Patients with known hypersensitivity to any component of the chemotherapy regimen will not be eligible Known hypersensitivity to any component of bevacizumab Known prior severe hypersensitivity to the investigational products or any component in their formulations, Known hypersensitivity to any component of the atezolizumab or cobimetinib formulations Known hypersensitivity or allergy to murine products or any component of the obinutuzumab, rituximab, idasanutlin, or venetoclax formulation History of hypersensitivity reactions to study drug or any component of the study drug formulation Known hypersensitivity to any study drug component Known hypersensitivity to any component of required drugs in the study Participation in the DES component of the study. Known allergy or reaction to any component of either study drug formulation Known allergy or hypersensitivity to any component of the atezolizumab formulation The tumor must not have an infratentorial component; Known hypersensitivity to immunoglobulins or to any other component of the IP formulation Subjects with known allergy or hypersensitivity to any component of the investigational product will be excluded Known allergy or reaction to any component of either study drug formulation Known hypersensitivity to any component of study drug including potential subjects with a history of major immunologic reaction to any IgG-containing agent History of hypersensitivity and anaphylactoid reactions to pneumococcal vaccine or any component of the formulation, including diphtheria toxoid Known allergy or reaction to any component of either study drug formulation Known hypersensitivity to immunoglobulins or to any other component of the IP formulation An allergy to a component of Levulan have a known or suspected allergy to the study drug or any study drug component; Known hypersensitivity or allergy to any component of the avelumab formulation Known hypersensitivity to any component of the investigational products History of hypersensitivity and anaphylactoid reactions to pneumococcal vaccine or any component of the formulation, including diphtheria toxoid Known hypersensitivity to an component of bevacizumab Known allergy or hypersensitivity to any component of the investigational drug product. Known hypersensitivity to any component of the nivolumab or ipilimumab product Known hypersensitivity to immunoglobulins or any other component of the study drug Known hypersensitivity to any component of the investigational product Known hypersensitivity to 5-fluorouracil, capecitabine, bevacizumab or to any component of the investigational products or compounds of similar chemical composition Known hypersensitivity to any study drug component. Known hypersensitivity to any component of the product (lenvatinib or ingredients). Serum M component (? 0.5 g/dL), or History of hypersensitivity to any component of the formulation History of hypersensitivity to active or inactive excipients of any component of treatment Known allergy or reaction to any component of the MEDI4736 formulation or its excipients Known hypersensitivity to any component of bevacizumab Known contraindication or hypersensitivity to any component of bevacizumab Known hypersensitivity to any component of Avastin Patient with documented hypersensitivity to any of the component medications History of hypersensitivity to any component of the formulation History of hypersensitivity to temsirolimus or its metabolites (including sirolimus), polysorbate 80, or to any component of the formulation History of hypersensitivity to any component of the formulation Known hypersensitivity to any component of topotecan or doxorubicin or other required drugs in the study Known hypersensitivity to any component of the study medication(s). Subject has known immediate or delayed hypersensitivity, intolerance or contraindication to any component of study treatment. Known prior severe hypersensitivity to investigational products or any component in their formulations Participant has hypersensitivity to any component of TMZ or dacarbazine. Known hypersensitivity to any temozolomide component or to dacarbazine (DTIC). Patients with a known hypersensitivity to 5-aminolevulinic acid or any component of the study material DOSE ESCALATION COHORT: Known allergy or reaction to any component of either study drug formulation; any history of serotonin syndrome (SS) after receiving 1 or more serotonergic drugs DOSE EXPANSION COHORT: Known allergy or reaction to any component of either study drug formulation; any history of serotonin syndrome (SS) after receiving 1 or more serotonergic drugs Known prior or suspected hypersensitivity to study drugs or any component in their formulations Hypersensitivity to pembrolizumab or any of its excipients, or a known history of hypersensitivity to IL-2 or any component of the formulation History of allergy or hypersensitivity to any component of the treatment Hypersensitive or intolerant to any component of the study drug(s) formulation Systemic hypersensitivity to Montanide ISA 51 VG or any vaccine component Systemic hypersensitivity to Montanide ISA 51 VG or any vaccine component Patients with a history of hypersensitivity to sirolimus or any component of the formulation. Known hypersensitivity to any study drug component Patients must not have any known allergy or reaction to any component of the MEDI4736 formulation Known allergy or hypersensitivity to any component of the atezolizumab formulation Known allergy or hypersensitivity to any component of the bevacizumab formulation Known hypersensitivity to any component of lenvatinib or midazolam. Known hypersensitivity to a component of protocol therapy Known hypersensitivity or allergy sunitinib or to chemically related products or likely to be exacerbated to by any component of the study products Known hypersensitivity to any study drug component including thapsigargin derivatives, polysorbate 20, or propylene glycol History of hypersensitivity to any component of the formulation. Patients with a known hypersensitivity to any component of bevacizumab are not eligible for this trial Subjects with known allergy or hypersensitivity to any component of the investigational product will be excluded Known hypersensitivity to capecitabine, fluorouracil, or any component of the formulation Extensive intraductal component Known immediate or delayed hypersensitivity reaction to carboplatin, paclitaxel, polysorbate 80, or any other component of the formulation Known hypersensitivity to any component of bevacizumab Known hypersensitivity to 5-fluorouracil or to any component of the investigational products or compounds of similar chemical composition Has a known hypersensitivity, intolerability or contraindication to any component of study treatment, including premedication Participants who have known hypersensitivity to any component of loperamide or budesonide Patients with a known hypersensitivity to any component of bevacizumab are not eligible for participation History of allergy or hypersensitivity to any component of the study drugs Known or suspected allergy or hypersensitivity to yeast or any other component of CRS-207 (e.g., glycerol), Platinol or platinum-containing compounds, or pemetrexed Known hypersensitivity to any component of bevacizumab Known hypersensitivity to any component of bevacizumab Subjects with less than 25% intraductal component Known hypersensitivity to any component of the trial agents Known hypersensitivity to any component of the formulation Known hypersensitivity to any component of bevacizumab Known hypersensitivity to somatostatin analogues or any component of the pasireotide or octreotide long-acting release [LAR] formulations History of hypersensitivity to any component of the formulation Known hypersensitivity to any component of bevacizumab CARBOPLATIN ARM: hypersensitivity to carboplatin or any component of the formulation Known hypersensitivity to any component of bevacizumab Known hypersensitivity to any component of bevacizumab and osimertinib Patients with known hypersensitivity to any component of bevacizumab History of allergy or reaction to any component of the MEDI-551 formulation History of known hypersensitivity to S. cerevisiae, bevacizumab or any component of FOLFOX or FOLFIRI; hypersensitivity skin test is required at screening to rule out allergy to S. cerevisiae Subject has known history of serious hypersensitivity reaction to ASP8273, or any component of the formulation used. Known hypersensitivity to any component of recombinant protein production by CHO cells Known allergy or hypersensitivity to any component of the study treatment(s) History of hypersensitivity and anaphylactoid reactions to pneumococcal vaccine or any component of the formulation, including diphtheria toxoid Known hypersensitivity to any component of study treatments that resulted in drug discontinuation Hypersensitivity to PEG or other component of AEB1102 (Co-ArgI-PEG) Known hypersensitivity to any component of atezolizumab formulation or other study medication Known hypersensitivity to any component of study treatments Known hypersensitivity to any component of study treatments Known hypersensitivity to bevacizumab or any component of its formulation Subject has a known history of serious hypersensitivity to ASP2215, or any component of the formulation used. Known hypersensitivity to any component of study treatments that resulted in drug discontinuation Known hypersensitivity to any component of study treatments Previous known sensitivity to any Fibrin Sealant Grifols component or any Surgicel® component. Known allergy or hypersensitivity to any component of the formulation of CA-4948 used in this study Known or suspected hypersensitivity to any component of GVAX Pancreas vaccine or CRS-207, or known allergy to both penicillin and sulfa Subjects who are known or suspected to be hypersensitive to any component of the study medications. Allergic to diphtheria toxin a component of the study drug A-dmDT390-bisFv(UCHT1). Subject has known history of serious hypersensitivity reaction to ASP8273, or any component of the formulation used. Known hypersensitivity to any component of RDHAP Known hypersensitivity to somatostatin analogs or any component of the pasireotide long acting release (LAR) or suspension concentrate (s.c.) formulations Known hypersensitivity to any component of the atezolizumab product Known hypersensitivity reaction to any component of ferric carboxymaltose Patients with known hypersensitivity to NT-I7 or any component used in the vehicle/formulation are ineligible Known hypersensitivity to any component of bevacizumab Known hypersensitivity to any component of testosterone Hypersensitivity/allergy or contraindication to any component of the stent, delivery system, or medication required to complete the procedure,which in the investigator's opinion cannot be adequately premedicated Educational component: men over the age of 18 Screening component: men over age 40 Documented hypersensitivity to any component of ranolazine (Ranexa) pills History of hypersensitivity or allergic reaction to NRT, or any component of its formulation Any known allergy or hypersensitivity to vaginal lubricants or any component of study product Known hypersensitivity to any component of the nivolumab or ipilimumab product History of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine. History of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine History of allergy or hypersensitivity to any component of the treatment Patients with known hypersensitivity or allergy to any component of Sonazoid. Patients with known hypersensitivity or allergy to any component of Definity Hypersensitivity to NVB or any of its excipients or to any component of AVD + BV therapy Patients with known hypersensitivity to any component of Definity micro bubble contrast Known hypersensitivity to gemcitabine or any component of the formulation.