History of congestive heart failure No congestive heart failure (CHF) within 182 days of registration Active congestive heart failure or ventricular arrhythmia requiring medication Congestive heart failure Must not have a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months Testing for LVEF is not required for pre-registration, but patient must not have a recent LVEF < LLN or have symptoms of congestive heart failure Symptomatic congestive heart failure Congestive heart failure (CHF) since axitinib can cause CHF History of pulmonary edema or decompensated congestive heart failure with in six (6) week of enrollment. Symptoms of congestive heart failure or uncontrolled cardiac rhythm disturbance Current symptomatic congestive heart failure or history of symptomatic congestive heart failure in the preceding 3 months, defined as New York (NY) Heart Association classification 2- 4 Presence of any serious concomitant systemic disorders incompatible with the study in the opinion of the investigator (e.g., uncontrolled congestive heart failure, active infection, etc.); Patients with history of congestive heart failure stage III or greater For participants with congestive heart failure, cardiovascular-related hospitalizations within 4 weeks prior to randomization Patients with history of congestive heart failure stage III or greater Symptomatic valvular heart disease Symptomatic congestive heart failure Been treated with appropriate maximal medical therapy for heart failure Patients with history of congestive heart failure are excluded Symptomatic heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction or symptomatic congestive heart failure Active heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction or symptomatic congestive heart failure Subject with significant congestive heart failure (CHF) or history of CHF, chronic renal failure, hepatic failure, neuropathy Significant history of a medical problem or co-morbidity that would preclude the patient from undergoing a major abdominal operation such as a history of severe congestive heart failure or active ischemic heart disease Previous hospitalization due to documented heart failure in the last 12 months Congestive heart failure < 6 months prior to screening Active heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction, or symptomatic congestive heart failure; also patients with a history of myocardial infarction that is < 1 year prior to registration, or patients with previous congestive heart failure (< 1 year prior to registration) requiring pharmacologic support or with left ventricular ejection fraction < 50% Presence of a symptomatic bradyarrhythmia or uncompensated heart failure Congestive heart disease not controlled by medication. Congestive heart failure (CHF) within 6 months prior to first dose; No acute congestive heart failure Current clinical heart failure or symptomatic ischemic heart disease History of myocardial infarction =< 6 months, or current symptomatic congestive heart failure or left ventricular ejection fraction (LVEF) < 40% or with > grade 2 diastolic dysfunction, with no symptoms or signs of heart failure Must not have a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months Congestive heart failure requiring medication (other than diuretic) Active ischemic heart disease or congestive heart failure Been treated with appropriate maximal medical therapy for heart failure Serious intercurrent medical illness (e.g., symptomatic congestive heart failure) Has a history of significant congestive heart failure or significant pulmonary disease Symptomatic congestive heart failure (CHF) Absence of clinically significant cardiomyopathy, congestive heart failure Absence of clinically significant cardiomyopathy, congestive heart failure Previous history of congestive heart failure The participant has symptomatic congestive heart failure or symptomatic cardiac arrhythmia. Cerebrovascular or cardiovascular event, or congestive heart failure within the last 6 months. Active congestive heart failure or ventricular arrhythmia requiring medication No congestive heart failure < 6 months Known active symptomatic congestive heart failure Patients with symptoms of congestive heart failure are not eligible History of congestive heart failure or other findings of ventricular dysfunction Symptomatic congestive heart failure Known congestive heart failure requiring medical management History of congestive heart failure or systolic dysfunction (LVEF <50%) History of symptomatic congestive heart failure within 6 months prior to the initiation of therapy on this protocol Congestive heart failure (CHF) within 6 months prior to first dose Evidence of uncontrolled congestive heart failure Symptomatic congestive heart failure History of congestive heart failure (CHF) Has symptomatic congestive heart failure (CHF) Active heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction, or symptomatic congestive heart failure; also patients with a history of myocardial infarction that is < 1 year prior to registration, or patients with previous congestive heart failure (< 1 year prior to registration) requiring pharmacologic support or with left ventricular ejection fraction < 45% Active heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction, or symptomatic congestive heart failure Uncompensated congestive heart failure Non-controlled intercurrent diseases, including active infections, symptomatic congestive heart failure, unstable chest angina or heart arrhythmia, as well as mentally incapable patients Grade 2 or greater congestive heart failure History of hospitalization for Congestive Heart Failure Patients with the clinical diagnosis of congestive heart failure or angina pectoris are NOT eligible Severe cardiovascular disease, i.e., arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease Patients cannot have known cardiac disease (either arrhythmia or congestive heart failure) requiring treatment Active heart disease including but not limited to symptomatic congestive heart failure, symptomatic coronary artery disease, symptomatic angina pectoris, symptomatic myocardial infarction or symptomatic congestive heart failure Serious intercurrent medical illness (e.g., symptomatic congestive heart failure) Patients with congestive heart failure or significant arrhythmia Symptomatic congestive heart failure Congestive heart failure. History of symptomatic congestive heart failure or serious cardiac arrhythmia requiring treatment History of congestive heart failure; Patients with history of congestive heart failure Symptomatic congestive heart failure History of congestive heart failure (CHF) Active symptomatic congestive heart failure Congestive heart failure (CHF) currently requiring therapy Active congestive heart failure or ventricular arrhythmia Symptomatic congestive heart failure; Congestive heart failure (CHF) currently requiring therapy No evidence of clinically significant congestive heart failure, (ejection fraction of 45% or greater) Has an active infection, congestive heart failure, slow heart rate, or other uncontrolled disease other than cancer Active heart disease Unstable congestive heart failure History or current symptoms of congestive heart failure (shortness of breath, ankle swelling) Clinical diagnosis of congestive heart failure and/or pulmonary capillary wedge pressure >15 mmHg, or uncorrected congenital heart disease. Congestive heart failure, Active symptomatic congestive heart failure Congestive heart failure requiring medication (other than diuretic) History of or active ventricular dysrhythmias or congestive heart failure requiring medication or symptomatic coronary heart disease Extremity edema due to heart failure Patients with history of congestive heart failure Congestive heart failure Congestive heart failure Receiving treatment for cardiomyopathy or congestive heart failure History of congestive heart failure and ejection fraction less than 35% History of congestive heart failure; systolic heart failure defined as ejection fraction (EF) =< 40%, or diastolic heart failure defined as EF > 40% PLUS systemic manifestation of heart failure Congestive heart failure (CHF) Patients with history of congestive heart failure No significant history of a medical problem or co-morbidity that would preclude the patient from undergoing a major abdominal operation such as a history of severe congestive heart failure or active ischemic heart disease Documentation of congestive heart failure and ejection fraction < 30% if recorded in the pre-operative record Any patient with known ischemic heart disease, history of congestive heart failure, history of stroke, or cardiac arrhythmia for which the patient requires medication or a medical device Congestive heart failure refractory to medical management NYHA stage 3 or 4 congestive heart failure Conditions that could cause swelling (e.g., pregnancy, congestive heart failure, chronic/acute renal disease, cor pulmonale, nephrotic syndrome, nephrosis, liver failure or cirrhosis, pulmonary edema, and thrombophlebitis, or deep vein thrombosis in arms Known heart disease Known heart disease Patients with congestive heart failure requiring pharmacological management Participant reported history of congestive heart failure Congestive heart failure Liver impairment or congestive heart failure Has an active infection (e.g., pneumonia), congestive heart failure, bradyarrhythmia, any uncontrolled disease (e.g., diabetic ketoacidosis, gastrointestinal obstruction) except for malignancy congestive heart failure History of renal disease, hypertension, diabetes, congestive heart failure or emphysema > stage 3 heart failure Worsening of or clinically unstable congestive heart failure Congestive heart failure, clinically significant History of congestive heart failure History of clinically significant congestive heart failure Participants with history of hypertension, congestive heart failure, edema, stroke or other cardiac disease or condition Patients with history of congestive heart failure Symptomatic congestive heart failure. Men who have contraindications to exercise based the American College of Sports Medicine 2016 Exercise pre-participation screening criteria and who do not receive a physician clearance to participate in the moderate intensity physical activity with one or more of the following self-reported conditions:\r\n* heart attack\r\n* heart surgery, cardiac catherization, or coronary angioplasty\r\n* pacemaker/implantable cardiac defibrillator/rhythm disturbance\r\n* heart valve disease \r\n* heart failure \r\n* heart transplantation \r\n* congenital heart disease \r\n* diabetes \r\n* kidney (renal) disease\r\n* chest discomfort with exertion \r\n* unreasonable breathlessness \r\n* dizziness, fainting or blackouts \r\n* ankle swelling \r\n* unpleasant awareness of forceful, rapid or irregular heart rate \r\n* burning or cramping sensations in your lower legs when walking short distance