General physical condition compatible with the proposed chemotherapy and surgery
Unresectable disease (e.g. immobile node on physical exam, nodal disease that radiographically involves the carotid arteries, nerves)
Has difficulty climbing a flight of stairs or walking eight blocks due to physical impairment
Patients must be without evidence of visceral or bone involvement with metastatic cancer on physical exam or any diagnostic study; extensive nodal involvement is allowed
Patients who have evidence of infection as determined by history, physical exam or laboratory testing (complete blood count and urinalysis) at baseline will be excluded unless otherwise approved by the PI or PI’s designee
In addition, patients who develop evidence of infection (as determined by history, physical exam or laboratory testing) during the study will be discontinued from the study unless otherwise approved by the PI or PI’s designee
Palpable splenomegaly ?5 cm below the lower costal margin in the midclavicular line as assessed by physical examination
Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or screening investigations
PHYSICAL AND LABORATORY TEST FINDINGS
Abnormal finding on physical exam (study physician discretion)
Any mental or physical condition or disease or past medical history that mitigates against following the protocol
Abnormalities on screening physical exam judged by study physicians or supervising physical therapist to contraindicate participation in exercise program compliance
Mini-mental status exam (MMSE) >= 24
In good physical condition to perform low-intensity daily steps (walking)
Willing to use Fitbit band to monitor physical activities
Already doing moderate to high physical activities in their daily life (rapid screener)
Active tuberculosis based on history, symptoms, physical exam, imaging
The patient must be clinically and radiographically node negative (N0) to participate on this protocol; clinically suspicious regional nodes by imaging or physical exam require biopsy evaluation to exclude disease involvement
Palpable spleen of > 10 cm below the left subcostal margin on physical examination at the screening visit OR
Palpable splenomegaly of 5 to 10 cm below left subcostal margin on physical exam AND active symptoms of MF at the screening visit as demonstrated by presence of 1 symptom score ? 5 or 2 symptom scores ? 3 using the Screening Symptom Form
Clinically =< 3 cm unifocal lesion by imaging or physical examination
Evidence by physical examination or mammography of other suspicious masses, densities, or microcalcifications in either breast, unless biopsied and found to be benign
Measurable disease by physical exam
Clinical stage =< T3a based on digital rectal exam and/or =< T3a based on magnetic resonance imaging (MRI) (if done); N0-Nx; M0-Mx (American Joint Committee on Cancer [AJCC] 7th edition)\r\n* T-stage and N-stage will be determined by physical exam including a digital rectal exam and available imaging studies (computed tomography [CT], and/or MRI of the pelvis); for MRI, extracapsular extension is permitted; to distinguish blood from tumor the ideal study would be to acquire T2, T1 noncontrast and T1 dynamic contrast enhanced sequence, although this is not required\r\n* M-stage determined by physical exam, CT of abdomen and pelvis with contrast, and bone scan
Absence of abnormal lymphadenopathy suggesting metastatic PTC on physical examination and/or imaging studies
Patients who have measurable disease must have had X-rays, scans or physical examinations used for tumor measurement completed within 28 days prior to initial administration of drug
Based on the neurosurgeon’s judgment, there is no anticipated physical connection between the post-resection tumor cavity and the cerebral ventricles
History and physical including neurological exam, height, weight, cranial skin exam, and Karnofsky performance status >= 70% within 30 days prior to registration
Inability to participate in study activities due to physical or mental limitations
Tumor measures at least 1 centimeter on imaging or physical exam
Inability to participate in study activities due to physical or mental limitations
No evidence of distant metastatic disease as documented by history and physical examination (radiographic staging only to be performed as indicated by symptoms or physical findings)
Nutritional and general physical condition must be considered compatible with the proposed radiation +/- chemotherapy treatment
Evidence of clinically significant neuropathy (> Grade 1) by physical exam.
History of liver decompensation: ascites noted on a physical exam, imaging or other test; variceal bleeding; hepatic encephalopathy
Patients must have fully intact mental status and normal neurologic abilities. Intact mental status is defined by ‘the capacity to identify and recall one's identity and place in time and space. Assessment of mental status and documentation of fully intact mental status by pediatric criteria, will be completed using physical and mental exam by the referring doctor or oncologist
Patients must be without evidence of visceral or bone involvement with metastatic cancer on physical exam or any diagnostic study; extensive nodal involvement is allowed
Patients with radiographic ascites that is apparent on physical exam or requiring medical intervention (medication or procedures) in the 2 months prior to enrollment
Based on the neurosurgeon's judgement, there is no anticipated physical connection between the post-resection tumor cavity and the cerebral ventricles
Physical and Laboratory Test Findings
Physical examination indicates Tanner Stage 1
Clinical evidence of ascites by physical exam
Palpable splenomegaly or hepatomegaly of more than or equal to 5 cm below left or right, respectively, costal margin on physical exam
Appropriate stage for protocol entry, including no clinical evidence for distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination, including breast exam and documentation of weight and Karnofsky performance status of 80-100% at study entry
No stage IV (metastatic) disease, however no specific staging studies are required in the absence of symptoms or physical exam findings that would suggest distant disease.
Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible
Stable physical and mental health
Patients must have fully intact mental status and normal neurologic abilities; intact mental status is defined by the capacity to identify and recall one's identity and place in time and space; assessment of mental status and documentation of fully intact mental status will be completed using physical and mental exam by the referring doctor or oncologist
PHASE II: Patients must be without evidence of visceral or bone involvement with metastatic cancer on physical exam or any diagnostic study; extensive nodal involvement is allowed
No stage IV (metastatic) disease, however no specific staging studies are required in the absence of symptoms or physical exam findings that would suggest distant disease.
Tumor diameter =< 2 cm on physical exam & imaging studies
Tumors > 2 cm in diameter on physical exam or imaging studies
Patients must be without visceral or bone involvement with metastatic breast cancer on physical exam or any diagnostic study; patients with extensive nodal involvement classified as stage IV disease, are eligible
Chronic GVHD manifestations that can be followed on physical or laboratory exam\r\n* Skin changes\r\n* Oral mucosa changes\r\n* Hepatic dysfunction\r\n* Diarrhea
The tumor should be approximately at least 1 cm, to account for variability in imaging and imaging occult disease (physical exam, mammography, ultrasound); we recognize that from time to time because of this variation, there might not be enough tissue available for analysis after surgical excision but this will allow the greatest opportunity to capture as many eligible patients as possible
Any physical, social, or psychiatric condition that would prevent effective cooperation or participation in the study
The patient must have a history and physical documented within four weeks of registration and be deemed by a medical oncologist to be ineligible for standard continuous course chemoradiotherapy with cisplatin
Measurable, non-bony disease (at least one lesion on radiographic or physical exam assessment measuring >= 2 cm in longest axis), as demonstrated by imaging or physical exam performed =< 28 days of study entry, provided no anti-tumor therapies or interventions have occurred in that time period
Palpable splenomegaly ? 5 cm on physical examination
Palpable primary breast tumor measuring >= 2.0 cm on physical exam or imaging prior to neoadjuvant chemotherapy
Presence of detectable (by physical exam) third-space fluid collections
Palpable splenomegaly of more than or equal to 5 cm below left costal margin on physical exam
Patients must have laboratory and physical examination parameters within acceptable limits by standard of practice guidelines prior to surgery as assessed by preoperative anesthesia assessment
Physical and Laboratory Test Findings
Unable to participate in all necessary study activities due to physical or mental limitations
Is considered medically unfit for the study by the investigator as a result of the medical interview, physical exam, or baseline investigations.
History and physical exam, and Karnofsky performance status of >= 70 within 30 days prior to registration
Bedridden, or physical debilitation such that study participation would not be feasible or would create undue hardship
Self-reported sexual dysfunction (Derogatis Interview for Sexual Functioning [DISF]-Male [M]-II score =< 20 in the sexual desire domain), and/or fatigue (Functional Assessment of Chronic Illness Therapy [FACIT]-Fatigue [F] score < 30), or physical dysfunction (self-reported difficulty in walking a 1/4 mile or climbing two flights of stairs, and short physical performance battery score [SPPB] between 4 to 9)
Has physical limitations that would prevent participation (e.g. blindness)
Myopathic or rheumatologic disease that impacts physical function
Dementia as assessed by a mini-mental status exam (MMSE) score < 24 on initial screening
Physical handicap that would prevent participation in program
Impairments in physical function, as defined by a score < 9 on the SPPB pre-screen
Patients who have difficulty walking or may not be able to complete the physical therapy measures
Any physical or mental health condition that would interfere with full participation in the study, including individuals who are unable to read consent materials or appear to lack the capacity to consent
Has difficulty climbing a flight of stairs due to physical impairment
Inability to travel to the NIH, for example, due to physical limitations, for the in-person evaluation(s)
Physical limitations (e.g., orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking program
A Mini-Mental State Exam Score (MMSE) of at least 26
Children who meet the above criteria, but whose treating oncologist advises against study participation for physical health, mental health (parent or child) or logistical reasons
Patient has physical and mental capabilities to take part in study
Chronic GVHD manifestations that can be followed on physical or laboratory exam; these include but are not necessarily limited to:\r\n* Skin changes \r\n* Oral mucosa changes\r\n* Bronchiolitis obliterans\r\n* Ocular changes
A score of 26 or below on the Mini Mental Status Exam (MMSE) triggers a review by an investigational team before enrolling
Myopathic or rheumatologic disease that impacts physical function
Suspected or confirmed physical closure of salivary gland ducts on either side
Physical exam demonstrating evidence of radiotherapy-related mucositis in the visible oral cavity and/or oropharynx consistent with mucous membrane toxicity greater than 0 using the Acute Radiation Morbidity Scoring Criteria
Absence of tumors:\r\n* Patients must undergo thorough physical examination of the leg undergoing surgery; if physical exam is equivocal for presence of tumors, then a normal magnetic resonance imaging (MRI) of the lower extremity will be required before eligibility is met\r\n* If there is evidence of plexiform neurofibroma or nodular neurofibroma of > 3 cm diameter on the ipsilateral leg, then they are ineligible for the study
Plexiform neurofibroma of any size, or nodular neurofibroma of > 3 cm diameter involving the ipsilateral leg, including the hip\r\n* If presence of plexiform is suspected but not certain on physical exam, MRI of the leg may be indicated to rule this out
Patient cannot comfortably be set up in the prone position (i.e. physical disability)
Unresectable disease (e.g. immobile node on physical exam, nodal disease that radiographically involves the carotid arteries, nerves)
Patients who are not able to use telephone-based interactive voice response software due to physical limitations (e.g., impaired hearing)
Suspected or confirmed physical closure of salivary gland ducts on either side
Individuals with a physical or mental impairment which would preclude their ability\n             to perform the intervention.
Physical deformities that could interfere with accurate acupuncture point location
Individuals unable to complete art therapy activities independently due to physical and/or mental impairment
Mini mental state exam score less than 19
Able to participate occasionally in mildly strenuous physical effort
Physical deformities that could interfere with accurate acupuncture point location
CESM and MRI exam performed within 3 months of one another
Subjects who, at screening, have abnormal vital signs and/or physical exam, including a temperature >= 38.0 C, systolic blood pressure =< 90 or > 180 mmHg, pulse =< 60 or > 130 beats per minute, new rash, signs of infection
Physical limitations that prevent participant from exercising
Documented splenomegaly of at least 5 cm below the costal margin as measured on inspiration by physical exam.
Any physical or mental limitation that would prevent participation in study activities (Including but not limited to grade 4 neuropathy or inability to ambulate)
Stable physical/mental health
Stable physical/mental health
In stable physical/mental health
stable physical/mental health,
Patients presenting to surgery clinic after receipt of NAC at outside hospital with documentation of cT4 or cN2/3 disease on initial outside physical exam and imaging studies
Patients receiving NAC and having a nodal complete clinical response as assessed by physical exam
Clinically detectable disease either by physical examination or radiographic studies
Physical limitation that would limit compliance with the study requirements
Must not have had an injection of a radioisotope 24 hours prior to exam
Physical limitation that would limit compliance with the study requirements
Normal tone on clinical exam
Evidence of distant disease on physical exam or initial imaging
Participant with at least one neck that is clinically N0 as defined by clinical exam (physical exam with CT and/or MRI as the gold standard of the N0 neck); stages T2, T3, or T4. N0–N3, excluding N2c for bilateral disease based on criteria from the American Joint Commission on Cancer
Patients with a grade 1/2 tumors and evidence of deep myometrial invasion or cervical involvement on preoperative imaging or physical exam
Subjects with a pathologically-proven diagnosis of classic HL or DLBCL with measurable disease by any imaging technique or physical examination
Clinical evidence of T1-4N1-2, T3-4N0 disease; this can be either by imaging studies or by physical exam findings
Medical history, physical exam, and vital signs within 30 days of enrollment
Patients must not have signs of bowel perforation necessitating surgery or “acute” abdomen evidenced by peritonitis on physical exam within 2 days prior to registration
Has not seen a doctor for an annual physical within the last year, not including an annual required physical for work, at baseline
Myopathic or rheumatologic disease that impacts physical function (PCS study)
Unable to provide consent due to a mental, emotional, or physical handicap, that keep them from understanding the consent information
Obvious physical or mental disability that would prevent participant from interacting with a tablet device
Major physical disability which would prevent subject from transferring from a chair to a bed and sitting in an upright position