Baseline urinalysis should show urine protein < 3+ and must be obtained within 28 days prior to registration; if urine protein is 3+ or greater, then urine protein by 24 hour collection must show less than 3 grams of protein
Urine protein: =< 30 mg/dl in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour (h) urine sample
? 200 mg/24 hours of monoclonal protein in the urine on 24-hour electrophoresis
Urine protein: =< 30 mg/dl in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour (h) urine sample
? 200 mg/24 hours of monoclonal protein in the urine on 24-hour urine electrophoresis (UPEP)
Urine protein =< 30 mg/g
Urine/protein creatinine ratio spot-check < 0.5 mg/mg
Urine protein =< 30 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hour urine sample
Or 24-hour urine protein < 1 g
Urine protein should be screened by urine analysis; if protein is 2+ or higher, 24-hour urine protein should be obtained; patients with 24-hour urine protein >= 1000 mg are excluded
Urinary protein excretion =< 500 mg/day
Urine M-protein ? 200 mg/24h
Urine monoclonal protein >200 mg/24 hour
Urine protein should be screened by urinalysis; if protein is 2+ or higher, 24 hour urine protein should be obtained and the level should be < 1000 mg for patient enrollment
Urine M-protein ?200 mg/24 hrs
Urine monoclonal protein (UPEP) ?200 mg by 24 hour urine.
?200 mg of monoclonal protein in the urine on 24-hour electrophoresis
Urine protein must be screened by urinalysis; if protein is 2+ or higher, 24-hour urine protein should be obtained and the level should be < 1000 mg for patient enrollment
Within the past 4 weeks: Urine monoclonal protein > 200 mg/24 hour
Urine M-protein ? 200 mg/24 h
Urinary protein < 2+ (unless total quantitative protein is < 500 mg protein/day as determined by 24 hour [H] urine collection)
Spot urine must not show 1+ or more protein in urine or the patient will require a repeat urinalysis; if repeat urinalysis shows 1+ protein or more, a 24-hour urine collection will be required and must show total protein excretion < 1000 mg/24 hours
Patients must have a 24 hour (hr) urine collection showing less than 2000 mg of protein; EXCEPTION: patients with hematuria will be eligible with up to 3000 mg protein per 24 hours provided they do not have casts, eosinophiluria or electrolyte wasting
Spot urine must not show 1+ or more protein in urine or the subject will require a repeat urinalysis. If repeat urinalysis shows 1+ protein or more, a 24-hour urine collection will be required and must show total protein excretion <1,000 mg per 24 hours.
Participants with urine protein ?1 gram/24 hour
Urine protein < 1+; if >= 1+, 24 hour urine protein should be obtained and should be < 1000 mg
Significant proteinuria: urinary protein/creatinine ratio >0.5 mg/mg in a non first void urine sample
Either urine protein < 1+ or measured 24 hour urine protein < 500 milligram
Continued from Inclusion #8: Serum creatinine </= 1.5 ULN or creatinine clearance (CrCl) >/= 45 mL/min (CrCl = Wt (kg) x (140-age)/72 x Cr level, female x 0.85) for pts w/ creatinine levels above institutional normal; Amylase & lipase < 1.5 x the ULN; Urinalysis (UA) must show less than 1+ protein in urine, or the pt will require a repeat UA. If repeat UA shows 1+ protein or more, a 24 hour urine collection will be required & must show total protein </= 1000 mg/24 hour to be eligible
Non-Measurable M Protein (serum or urine) and measurable sFLC (< 100 mg/mL)
mGPS of 1: C-reactive protein >10 mg/L and albumin ?35 g/L
mGPS of 2: C-reactive protein >10 mg/L and albumin <35 g/L
Urine M-protein ? 200 mg/24 hr, or
Urine protein/creatinine < 1 mg/mg
Urine protein < 1+; if >= 1+, 24 hour urine protein should be obtained and should be < 1000 mg
mGPS of 2: C-reactive protein (CRP) > 10 mg/L and albumin < 35 g/L
mGPS of 1: C-reactive protein (CRP) > 10 mg/L and albumin ? 35 g/L
C-reactive protein >10 mg/L AND albumin ?35 g/L; Score = 1
C-reactive protein >10 mg L AND albumin <35 g/L; Score = 2
Urine M-protein ? 200 mg/24 h
Urine protein < 1+; or if >= 1+ then 24 hour urine protein should be obtained and should be < 1000 mg
Urine monoclonal protein >200 mg on 24 hour electrophoresis
Kidney: albuminuria ? 500 mg/day in a 24-hour urine specimen
Urine Bence Jones protein ? 200 mg/24 hr
Urine protein/creatinine ratio (UPCR) =< 1 mg/mg (113.2 mg/mmol) creatinine or 24-hour (hr) urine protein of < 1 g
Urine M-protein ? 200 mg/24 hour, or
Urine M ?200 mg per 24hr
Urine M protein ?200 mg per 24hr
Urine M protein ?200 mg per 24hr
Subjects must have a C-reactive protein (CRP) > 3 mg/L
Have detectable disease measured by a specific protein in your blood and/or urine
Patients unwilling or unable to comply with the protocol, including providing 24-hour urine samples for urine protein electrophoresis at the required time points.
C-reactive protein > 3 mg/L