Participants who have a history of non-compliance to medical therapies Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance to medical regimens History of non-compliance to medical regimens Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance to medical regimens Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will be unable to complete the entire study. Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance to medical regimens History of non-compliance to medical regimens History of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance with medical regimen, or patients potentially unreliable and/or not cooperative History of non-compliance to medical regimens Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance to medical regimens Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study History of non-compliance to medical regimens Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Non-compliance Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will not be able to complete the entire study or patient diaries;