Untreated central nervous system (CNS) metastases or CNS metastases that have progressed Untreated or active central nervous system metastases Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases; Active or untreated central nervous system (CNS) metastases Symptomatic and/or untreated central nervous system metastases Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Participants with known untreated brain or other central nervous system metastases are excluded Any untreated central nervous system (CNS) lesion. Active or untreated central nervous system (CNS) metastases Symptomatic or untreated central nervous system (CNS) metastases Patients with untreated central nervous system metastases Presence of symptomatic or untreated central nervous system (CNS) metastases Symptomatic and/or untreated central nervous system metastases Untreated central nervous system (CNS) metastases Untreated, symptomatic Central nervous system (CNS) metastases Known, current central nervous system disease involvement or untreated brain metastases Untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) metastases Exclusions Related to Cardiovascular Disease Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases. Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases Active, untreated central nervous system (CNS) metastases Patients with known brain metastases, active infection, or untreated central nervous system (CNS) leukemia Untreated or active central nervous system metastases - Ongoing or recent (within 5 years) evidence of significant autoimmune disease Untreated or progressive central nervous system leukemia Patients with symptomatic, untreated central nervous system (CNS) metastases are not eligible Patients with untreated brain metastases/central nervous system (CNS) disease will be excluded Symptomatic untreated metastases in the central nervous system Active or untreated central nervous system (CNS) metastases Active, untreated central nervous system metastases. Central nervous system metastases that are untreated or symptomatic, or require radiation, surgery, or continued steroid therapy to control symptoms within 14 days of study entry. Subjects with symptomatic, untreated metastases to the central nervous system (CNS) at the time of screening. Known untreated central nervous system (CNS) metastases; leptomeningeal disease will be an absolute exclusion criterion due to limited life expectancy Symptomatic or untreated central nervous system (CNS) metastases Untreated brain metastases or neurologically unstable central nervous system (CNS) metastases Active, untreated central nervous system metastases. Untreated central nervous system (CNS) metastases or CNS metastases that have progressed Untreated or symptomatic central nervous system (CNS) metastases known central nervous system (CNS) metastases that are untreated, symptomatic, or require steroids to control symptoms Known active or untreated central nervous system (CNS) metastases. - Pregnant, planning to become pregnant within 6 months of treatment, or nursing. Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Subject has symptomatic and untreated central nervous system (CNS) disease Known and untreated brain metastases. Patients with primary CNS (central nervous system) malignancies are excluded. Known and untreated, or active central nervous system (CNS) metastases (progressing or requiring treatment) Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Participant has untreated central nervous system (CNS) metastases. Untreated or active/progressing Central Nervous system (CNS) metastases Known untreated or active central nervous system (CNS) metastases Patients with untreated or symptomatic central nervous system (CNS) metastases Untreated or symptomatic central nervous system metastases. Symptomatic and/or untreated central nervous system metastases Known, current central nervous system disease involvement or untreated brain metastases Untreated or symptomatic central nervous system (CNS) metastases Untreated central nervous system metastatic disease l Untreated central nervous system (CNS) metastases Known active or untreated central nervous system (CNS) metastases Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases Patients with untreated central nervous system (CNS) or epidural tumor Any untreated central nervous system (CNS) lesion Presence of untreated/active central nervous system (CNS) metastases Symptomatic or untreated central nervous system (CNS) metastases requiring concurrent treatment Has active or untreated brain or central nervous system metastases. Untreated central nervous system (CNS) metastases or CNS metastases that have progressed after completion of radiotherapy. Active, untreated central nervous system metastases. Active, untreated central nervous system metastases. Active or untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) lesions Untreated central nervous system (CNS) metastatic disease Presence of clinically apparent untreated central nervous system metastases. Untreated brain or central nervous system (CNS) metastases Untreated or active central nervous system (CNS) metastases. Participants with a history of treated CNS metastases may be eligible Untreated central nervous system metastases Active or untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) metastases Patients with untreated central nervous system metastases or local treatment of brain metastases Symptomatic and/or untreated central nervous system metastases Untreated or active central nervous system (CNS) metastases. Untreated central nervous system metastases Untreated/active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control) Untreated or active brain metastases or central nervous system cancer, as defined per protocol Untreated or active cerebral nervous system metastases Known untreated or active central nervous system (CNS) metastases Untreated or active central nervous system (CNS) metastases Primary central nervous system (CNS) malignancy or untreated/active CNS metastases Untreated central nervous system (CNS) metastases. Central nervous system (CNS) disease that is untreated, symptomatic, or requires therapy to control symptoms. Known and untreated, or active central nervous system metastases Known primary central nervous system (CNS) malignancy or untreated or active CNS metastases Subjects with untreated Central nervous system (CNS) metastases are excluded Symptomatic, untreated or unstable central nervous system or leptomeningeal metastases Active, untreated central nervous system metastases. Criteria 6, Active or untreated central nervous system (CNS) metastases per CT or MRI evaluation during screening