Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function Adequate end-organ function Adequate hematologic and end organ function based on laboratory results obtained within 14 days prior to initiation of study treatment; Adequate hematologic and end-organ function, defined by laboratory test results, obtained within 14 days before initiation of study treatment Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Cancer-Related Inclusion Criteria: Adequate hematologic and end-organ function Adequate hematologic and organ function Adequate hematologic and end-organ function Adequate hematologic and organ function within 28 days before the first study treatment Adequate hematologic and end organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function The participant has adequate hematologic, organ, and coagulation function ?2 weeks (14 days) prior to first dose of study drug: Adequate haematologic and end-organ function Adequate hematologic and end-organ function Have adequate hematologic, organ and coagulation function within 2 weeks (14 days) prior to enrollment. Adequate hematologic and organ function Adequate hematologic and end organ function obtained within 2 weeks prior to first dose of study drug Adequate End organ function Adequate hematologic and end organ function Adequate end-organ function Adequate end-organ function, as determined by laboratory tests obtained within 28 days prior to the first dose of study drug Adequate hematologic and end-organ function Adequate hematologic and end-organ function. Adequate hematologic and end organ function Adequate hematologic and organ function within 28 days prior to initiation of study treatment Adequate hematologic and end-organ function test results Adequate hematologic and end organ function Adequate hematologic and end organ function, confirmed by laboratory results obtained within 28 days prior to initiation of study drug Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function within 28 days prior to treatment initiation Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end organ function Adequate hematologic and organ function within 14 days before the first study treatment Adequate hematologic and end organ function, defined by the following laboratory results obtained within 14 days prior to the first study treatment (Cycle 1, Day 1): Adequate hematologic and end organ function Adequate hematologic and end organ function Cohort 2-Specific Inclusion Criteria Have adequate organ and hematologic function, as determined by: Adequate hematologic and end organ function Adequate hematologic and end-organ function Patients must have adequate hematologic and organ function. Adequate hematologic and end organ function Acceptable hematologic and organ function Adequate hematologic and end organ function, defined by the following laboratory results obtained within 14 days prior to the first study treatment (Cycle 1, Day 1) Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and organ function within 14 days before the first study treatment Adequate hematologic and end organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Patients must have normal organ and hematologic function therapy Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and organ function within 14 days prior to treatment initiation Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end organ function Adequate hematologic, cardiac, and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end-organ function Adequate hematologic and end organ function Adequate hematologic and end-organ function