Glucose-6-phosphate dehydrogenase (G6PD) deficiency (i.e. below normal limits) A history of glucose-6-phosphate dehydrogenase (G6PD) deficiency Patients with known G6PD deficiency are NOT ELIGIBLE for Rasburicase therapy. Patients with G6PD deficiency should be treated with alkalinization, IV hydration and po and/or IV allopurinol during the reduction phase (COP). A history of known glucose-6-phosphate dehydrogenase (G6PD) deficiency G6PD (glucose-6-phosphate dehydrogenase) deficiency History of G6PD deficiency, hereditary spherocytosis or hemochromatosis History of known glucose-6-phosphate dehydrogenase (G6PD) deficiency Undetectable haptoglobin or evidence of glucose-6-phophate dehydrogenase (G6PD) deficiency, pyruvate kinase deficiency, hemoglobinopathy, hereditary spherocytosis, thalassemia or other disorder associated with hemolysis Known glucose-6-phosphate dehydrogenase (G6PD) deficiency G6PD (glucose-6-phosphate dehydrogenase) deficiency Subjects with known glucose 6 phosphate dehydrogenase (G6PD) deficiency Known G6PD (glucose-6-phosphate dehydrogenase) deficiency (below lower limit of normal) Patients with known history of G6PD deficiency G6PD (glucose-6-phosphate dehydrogenase) deficiency Patients with known glucose-6-phosphate dehydrogenase deficiency (G6PD) are excluded; pre-registration testing for G6PD is at the investigator’s discretion and is not required for study enrollment G6PD (glucose-6-phosphate dehydrogenase) deficiency G6PD (glucose-6-phosphate dehydrogenase) deficiency Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Glucose-6-phosphatase deficiency (G6PD) level of 5-14 units/g hemoglobin (Hgb) or within institutional standard parameters Known/established G6PD (glucose-6-phosphate dehydrogenase) deficiency Glucose-6-phosphate dehydrogenase (G6PD) deficiency History of known glucose-6-phosphate dehydrogenase (G6PD) deficiency A history of known glucose-6-phosphate dehydrogenase (G6PD) deficiency Known Glucose-6-phosphate-dehydrogenase deficiency (G6PD). Glucose-6-phosphate dehydrogenase (G6PD) status normal Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency A history of known glucose-6-phosphate dehydrogenase (G6PD) deficiency Patients with known glucose-6-phosphate dehydrogenase deficiency (G6PD) are excluded due to an inability to administer the antidote for methemoglobinemia, methylene blue; testing for G6PD is not required for study enrollment and optional A history of known glucose-6-phosphate dehydrogenase (G6PD) deficiency PART I: Glucose-6-phosphate-dehydrogenase (G6PD) deficiency PART II: Glucose-6-phosphate-dehydrogenase (G6PD) deficiency A history of glucose-6-phosphate dehydrogenase (G6PD) deficiency Patients with G6PD deficiency. Known G6PD (glucose-6-phosphate dehydrogenase) deficiency Known G6PD (glucose-6-phosphate dehydrogenase) deficiency Has glucose-6-phosphate dehydrogenase (G6PD) deficiency Known history of glucose-6-phosphate dehydrogenase (G6PD) deficiency Known intolerance of niacin or ascorbic acid (including known glucose-6-phosphate dehydrogenase [G6PD] deficiency)