Serum creatinine level =< IULN within 28 days prior to registration Within 28 days prior to registration: Serum creatinine =< 2.0 x IULN Patients must have adequate renal function with serum creatinine level =< IULN within 21 days prior to registration Serum creatinine =< 2.0 x IULN within 28 days prior to registration Patients must have creatinine clearance =< 2.5 x IULN Patients must have serum creatinine =< 2 x institutional upper limits of normal (IULN) within 7 days prior to registration Serum creatinine =< 1.5 x the IULN Creatinine =< 1.5 x IULN OR creatinine clearance >= 40 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN (that is, if serum creatinine is > 1.5 x IULN, a 24-hour urine collection to calculate creatinine clearance must be performed) Creatinine =< IULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with serum creatinine levels above institutional normal (IULN) (calculated by creatinine clearance estimate by Cockcroft-Gault equation) Serum creatinine =< 1.5 x institutional upper limit of normal (IULN) OR creatinine clearance by Cockcroft-Gault >= 60 mL/min for patients with serum creatinine > 1.5 x IULN Serum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 30 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN Adequate renal and hepatic function (creatinine ? 2.0 x IULN, bilirubin ? 1.5 IULN, AST and ALT ? 3.0 x IULN or 5 x IULN if known liver metastases). Serum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN Serum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN Serum creatinine < 3 x IULN Adequate renal and hepatic function (creatinine ? 1.5 x IULN, bilirubin ? IULN, AST and ALT ? 3.0 x IULN or 5 x IULN if know liver metastases). Creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 50 mL/min for patients with creatinine levels > 1.5 x IULN Adequate renal and hepatic function (creatinine ? 1.5 x IULN, bilirubin within normal limits, AST and ALT ? 3.0 x IULN or 5 x IULN if know liver metastases) Creatinine =< 1.5 x IULN Within 14 days of subject registration: Serum creatinine =< 1.5 X IULN Baseline BNP > 2 x IULN Serum creatinine =< 1.5 x IULN Serum creatinine =< 2 x institutional upper limit of normal (IULN), unless due to lymphoma, within 42 day prior to registration Performed within 14 days of patient registration: Serum creatinine =< 1.5 x IULN Serum creatinine =< IULN within 14 days prior to registration Serum creatinine =< 1.5 x IULN within 14 days prior to Step 2 Randomization OR Serum creatinine =< 1.5 x IULN within 14 days prior to Step 3 registration OR Baseline troponin I or T > IULN and b-type natriuretic peptide > IULN Serum creatinine level =< IULN Serum creatinine =< 1.5 x IULN (assessed within 7 days prior to study day 1) Serum creatinine =< 1.5 x IULN OR creatinine clearance by Cockcroft-Gault >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x IULN Serum creatinine < 2.0 x IULN within 28 days prior to registration Serum creatinine =< 2.0 x IULN Serum creatinine =< 1.5 x IULN obtained within 28 days prior to registration Transaminases =< IULN