No contraindication for surgery Known hypersensitivity to the trial drugs or other contraindication to standard “7+3” induction chemotherapy Any medical or physical contraindication, or other inability to undergo hematopoietic progenitor cell (HPC) collection Surgery, unless documented contraindication Radiotherapy, unless documented contraindication Chemotherapy, unless documented contraindication Contraindication to angiography or chemoembolization medications History of thromboembolic disease or uterine cancer that is considered a contraindication to tamoxifen Known contraindication to phosphodiesterase-5 inhibitors (e.g. currently on nitrates) Any known factors that would pose a contraindication to receiving nivolumab History of documented anaphylaxis or contraindication to any of the study medications Contraindication to epidural per Pain Service guidelines All patients with tumors involving the thoracic esophagus must undergo bronchoscopy to document the absence of a fistula no known contraindication to the use of taxanes or platinum compounds Contraindication to angiography/embolization procedure based on judgment of the treating investigator Contraindication to MRI Participant has a contraindication to biopsy Medical contraindication to receipt of radiotherapy No contraindication to tumor biopsy at time of study enrollment Patients in whom there is a medical contraindication or potential problem in complying with the requirements of the protocol, in the opinion of the investigator. Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy Contraindication to RPFNA including breast implant(s), bilateral radiation, anticoagulation (excluding those on 81 mg aspirin) Contraindication to receiving radiotherapy Known contraindication for topotecan or temozolomide Extensive loculations or hydropneumothorax or other contraindication to pleurodesis Contraindication or precaution for enzalutamide Has a contraindication (sensitivity or allergy) to trimethoprim/sulfamethoxazole and ampicillin. Contraindication to receive radiotherapy Contraindication to IV contrast Patients with contraindication to thromboprophylaxis Any contraindication to therapy with nivolumab Medical contraindication to radiation treatment (e.g. active systemic sclerosis, other uncontrolled autoimmune condition) CRITERIA FOR SCREENING: Any known and irreversible contraindication to huJCAR014 therapy Contraindication to the use of PTX Has a history or current evidence of physical or physiological contraindication to participation in this study, at the discretion of the treating investigator Patients with any contraindication to receiving rhuGM-CSF based products Absence of contraindication for Ommaya reservoir Any contraindication to the combination anti-cancer agent as per local prescribing information Contraindication to any of the individual components of CHOP, including prior receipt of anthracyclines Active uncontrolled infection that would be a contraindication to safe use of high-dose therapy Contraindication to any concomitant medication, including pre-medications or hydration given prior to therapy No contraindication to be on a minimum of 81 mg aspirin a day (or other anticoagulant therapy as prescribed) for thromboembolism prophylaxis Contraindication to intravenous (IV) contrast Patients who have contraindication to cyclophosphamide chemotherapy Contraindication for undergoing MRIs Subjects with a contraindication to MR-HIFU. Medical contraindication to the use of varenicline OR nicotine patch Medical contraindication to the use of bupropion Patients with any contraindication to receiving rhuGM-CSF based products Contraindication to receiving HCQ or TACE Contraindication to or unwillingness to undergo study related procedures including a repeat bronchoscopy The patient has a contraindication (e.g. sensitivity/allergy) to both trimethoprim/sulfamethoxazole and ampicillin Contraindication or unwillingness to undergo multiple CT scans Contraindication to receiving radiotherapy or TACE Presenting with a general or visceral contraindication to intensive treatment including: Patient has a known hypersensitivity or contraindication to study products that, in the opinion of the investigator, cannot be adequately pre-medicated Patient with contraindication for imaging with MRI HAPLOIDENTICAL RELATED DONOR: History of other medical conditions that in the opinion of PI constitute a contraindication to donation Requires treatment with other medications that cannot be stopped and for which there is a known contraindication to co-administration of one or more of the study drugs. Have known contraindication to Gd-MRI. Medical contraindication to apheresis Contraindication for MRI scanning (as assessed by local MRI safety questionnaire), which includes but is not limited to: Patients with contraindication for treatment by laparoscopy Known contraindication to aromatase inhibitor or SERM therapy Part 2: have a major contraindication to MP (e.g., allergy/hypersensitivity to study medications or their constituents), or conditions making adherence difficult as determined by the attending physician Has a contraindication to administration of amoxicillin, ampicillin, ciprofloxacin, erythromycin, gentamycin, penicillin, trimethoprim/sulfamethoxazole, and vancomycin Participants in whom there is a medical contraindication or potential problem in complying with the requirements of the protocol, in the opinion of the investigator Any medical or physical contraindication or any other inability to undergo HSPC collection Any medical or physical contraindication or other inability to undergo HSPC collection Contraindication to cisplatin chemotherapy or plans to alter or reduce cisplatin therapy Contraindication to treatment for TE prophylaxis Contraindication to any drug in the chemotherapy regimen, and specifically Has a contraindication to administration of ampicillin or trimethoprim/ sulfamethoxazole. Any contraindication to oral agents. Known or suspected hypersensitivity to ofatumumab or SB-485232 that in the opinion of the investigator is a contraindication to their participation in the study Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy Medical contraindication to undergoing MR imaging Contraindication to all available herpes simplex virus (HSV)/varicella prophylactic antiviral drugs Patients who have contraindication to MRI Has a contraindication to administration of trimethoprim/sulfamethoxazole or ampicillin. Any contraindication to ECP, i.e. contraindication to heparin or methoxsalen (8-MOP) Has a contraindication to administration of trimethoprim/sulfamethoxazole or ampicillin. Clear contraindication for systemic corticosteroids (diabetes mellitus is not per se a clear contraindication); Patients with contraindication to thromboprophylaxis Contraindication to MRI Participants with contraindication to RT while adjuvant RT is clinically indicated Contraindication to any concomitant medication, including antivirals or anticoagulation Contraindication to any concomitant medication, including antivirals, anticoagulation prophylaxis, tumor lysis prophylaxis, or hydration given prior to therapy. Contraindication to any concomitant medication, including antivirals or anticoagulation Contraindication to heparin as per NCCN guidelines Contraindication to corticosteroids Contraindication to EUS-guided needle puncture into the pancreas Patients with contraindication to steroid use Contraindication to chemotherapy or radiation Contraindication to gadolinium-enhanced MRI imaging Patients with a contraindication (e.g. sensitivity/allergy) to trimethoprim/sulfamethoxazole or ampicillin Contraindication to any concomitant medication, including antivirals or anticoagulation Any contraindication for TACE. Any contraindication for doxorubicin administration: Subjects with an absolute contraindication to corticosteroid administration Contraindication to propranolol, etodolac Patients with any known contraindication to treatment with, including hypersensitivity to quinacrine or erlotinib Contraindication to concomitant anticoagulation prophylaxis Any other contraindication listed in the local labeling of dalteparin, enoxaparin, or edoxaban; Any contraindication to MRI examination Contraindication to potential treatment agents Known hypersensitivity or contraindication to study drugs, oxazolidinones, or quinolones. Known contraindication to dexamethasone Contraindication to any of the required concomitant drugs, including antiviral (e.g. Valacyclovir) Contraindication for all comparators: Patients with contraindication to dexamethasone. Any contraindication to gemcitabine therapy Known or suspected hypersensitivity to ofatumumab or bendamustine that in the opinion of the investigator is a contraindication to their participation in the present study. Contraindication for nicotine patch use History of documented anaphylaxis or contraindication to any of the study medications Contraindication or allergy to intravenous lidocaine Subject, as deemed by treating investigator has contraindication to endoscopy or Spray Cryotherapy Procedure. Any contraindication to cardiac stress testing Patients with a history of documented anaphylaxis or contraindication to any of the study medications or standardized intra-operative medications; these include Dilaudid, fentanyl, and bupivacaine Major contraindication to methylphenidate i.e. hypersensitivity Medical contraindication to exercise Pregnant patients will not be included in the study as pregnancy is a relative contraindication for these types of surgical procedures Major contraindication to ginseng: allergy/hypersensitivity to Panax species or their constituents (history of arrhythmias, agitation, or motor tics, or severe angina pectoris) Contraindication to placement of an IPC (e.g., uncorrected coagulopathy) Known contraindication to receiving G-CSF Allergy or other contraindication to morphine sulfate Participant has allergy or other contraindication for morphine or gabapentin therapy Contraindication for the nicotine patch (e.g., heart attack, angina, skin allergies) unless a doctor’s note is provided. Contraindication to NRT; Medical contraindication to receipt of radiotherapy Any contraindication for GVHD prophylaxis with mycophenolate mofetil, cyclosporine A, or tacrolimus No known contraindication to NSAID use Have no contraindication to NRT Have a contraindication to NRT Patients who have a contraindication to radiation therapy Presence of any contraindication for a neurosurgical procedure contraindication to anticoagulant therapy Contraindication to MRI Contraindication to PET Contraindication to Lasix Any contraindication to bronchoscopy, for example: Inability or contraindication to undergo transcatheter arterial embolization Study Note: a patient with a contraindication to MRI will be excluded from the MRI portion of the study, but will still be asked to continue with the biopsy and C13 glucose infusion portion of the trial Known hypersensitivity to glucagon (contraindication for glucagon IV, required for endorectal MRI only) Pheochromocytoma, insulinoma or galactosemia (contraindication for glucagon IV, required for endorectal MRI only) Insulin?dependent diabetes (contraindication for glucagon IV, required for endorectal MRI only) Contraindication to MRI Contraindication to PET Contraindication to MRI or history of adverse reaction to gadolinium Contraindication for MP MRI Known intolerance, hypersensitivity, or contraindication to glucocorticoids. Contraindication or allergy to Feraheme (based on insert) Contraindication to MRI Contraindication to potassium iodide Contraindication to prostate mpMRI (renal failure, hip prosthesis, pacemaker, etc) Contraindication to prostate biopsy via transrectal or transperineal approaches (including coagulopathy) Contraindication to use of fluoropyrimidines as a radiosensitizing agent Contraindication to prostate biopsy Claustrophobia or any other contraindication to MRI imaging evaluated by a standardized safety questionnaire Patient who has a contraindication to endoscopy Have no contraindication to short-term atorvastatin therapy History of any condition deemed by the principal investigator to be a contraindication to B-WARM therapy (e.g., skin reaction, dysregulation of thermoregulation, etc) Have a contraindication to NSAIDs at the oncologist’s discretion (i.e., allergy, worsening of ongoing medical problem due to NSAID, low platelet count from chemotherapy, and uncontrolled condition such as hypertension or asthma) Contraindication to test article, constituents, or required concomitant medications