Patients with a history of allergic reaction to irinotecan, cephalosporins or a severe penicillin allergy are not eligible Prior allergic reaction to the hormones involved in this protocol Prior allergic reaction to the study drug(s) involved in this protocol Prior allergic reaction to carboplatin, paclitaxel, and/or cisplatin Patients who are allergic to milk Must not have known allergic reaction against any of the components of the study treatment Previous allergic reaction to an immunomodulatory drug (IMiD) Use of steroids for non-tumor indications (for example: asthma or severe allergic reaction) is permitted History of allergic reaction/hypersensitivity to temozolomide, dacarbazine, DSF or Cu. Patients may not have a history of allergic reaction or hypersensitivity to microcrystalline cellulose (Avicel PH302) or polysorbate 80 (Tween 80), which are components of the drug product MGCD516 History of allergic reaction to docetaxel Any history of allergic reaction to chemotherapies used History of allergic reaction to alpha-1-antitrypsin. Patients with hypersensitivity or other allergic reaction to platinum chemotherapy. Patients with hypersensitivity or other allergic reaction to taxanes. Known allergic reaction to antibiotics of the aminoglycoside group (ie, streptomycin, gentamicin) History of allergic reaction (including erythema nodosum) to lenalidomide Allergic reaction to single-agent rucaparib or irinotecan Prior allergic reaction or known intolerance to irinotecan If in Arm G, significant allergic reaction to cisplatin. Prior allergic reaction to cisplatin Patients with a history of severe allergic reaction to cisplatin or carboplatin Patient with prior allergic reaction to metformin, doxycycline, or any other tetracycline antibiotic in the past History of anaphylaxis or serious allergic reaction to carboplatin or paclitaxel Documented allergic or acute hypersensitivity reaction attributed to antibody treatments Prior allergic reaction to cisplatin History of allergic reaction to interleukin-2 or nivolumab Prior allergic reaction to metformin, doxycycline, or any other tetracycline antibiotic in the past History of a severe allergic reaction or anaphylactic reaction to a biological agent or history of hypersensitivity to any component of the trial drug (e.g., hypersensitivity or allergy to murine products). History of any serious adverse reaction or hypersensitivity to cytarabine, unless reaction is deemed irrelevant to the study by the Investigator and Medical Monitor The subject has a history of serious allergic reaction to any substance, resulting in hospitalization or requiring other emergent medical attention History of allergic reaction to DSF or Cu Allergic to temozolomide (TMZ) History of allergic reaction to intravenous iodinated contrast media is not contraindication to the study; patients with history of mild allergic reaction to iodinated contrast media will be premedicated with 40 mg of prednisone orally (p.o.) 12 and 2 hours (hrs) before the transarterial chemoperfusion treatment to prevent allergic reaction; patients with history of moderate and severe allergic reaction to iodinated contrast media or patients with history of mild allergic reaction to iodinated contrast media despite adequate premedication will undergo angiogram using carbon dioxide or a gadolinium based contrast agent History of allergic reaction to natalizumab Known serious allergic reaction to vandetanib or metformin Prior allergic reaction to the study drug(s) involved in this protocol Any allergic reaction to a previously administered monoclonal antibody or other therapeutic protein History of hypersensitivity or allergic reaction to varenicline, NRT, or any component of these formulations Prior allergic reaction to temozolomide Previous severe or life-threatening allergic reaction with rituximab or known allergy to the compounds found in INCB7839 Prior allergic reaction to the hormones involved in this protocol Patients with known history of allergic reaction to intravenous (IV) contrast material that is not amenable to pre-treatment by University of Alabama at Birmingham (UAB) protocol History of Grade 3 or higher allergic reaction with prior asparaginase treatment, No prior known allergic reaction to monoclonal antibodies History of >= 2 allergic reaction or any grade anaphylactic reaction during prior administration of tocilizumab Subject has prior severe allergic reaction or intolerance to a monoclonal antibody, including humanized or chimeric antibodies. Subject has prior severe allergic reaction or intolerance to any component of mFOLFOX6. Previous allergic reaction to radioisotope bone tracers Known history of serious allergic reaction including anaphylaxis or Stevens- Johnson syndrome/ toxic epidermal necrolysis History of any hypersensitivity or allergic reaction to any beta lactam antibiotic, tazobactam, or any study therapy (IV or oral) Prior allergic reaction or hypersensitivity to cetuximab or MEDI4736 (durvalumab) or any of study drug excipients Patients with a lifetime history of dermatitis as an allergic/toxic reaction to any medication Prior allergic reaction to cetuximab History of severe allergic reaction, including erythema nodosum, to lenalidomide Patients who are allergic to micafungin and/or voriconazole or any of their ingredients Documented severe allergic reaction to intravenous (IV) iodinated contrast, specifically bronchospasm and anaphylaxis Prior known allergic reaction to pembrolizumab or its excipients Prior allergic reaction to cisplatin Patients with any history of allergic reaction to paclitaxel or other taxanes or carboplatin Prior allergic reaction to the study drug(s) involved in this protocol Patients will be excluded if there is any history of allergic reaction(s) attributed to compounds of similar composition to temsirolimus, sorafenib, their metabolites, or any component of their formulation (including excipients and polysorbate 80); this includes hypersensitivity to macrolide antibiotics due to potential for cross-reactivity with temsirolimus History of clinically significant allergic reaction attributed to any injected\n compound. Prior allergic reaction to any of the study drugs involved in this protocol Prior allergic reaction to the study drug(s) involved in this protocol Prior allergic reaction to the study drugs involved in this protocol or to a monoclonal antibody Known contraindication to dexamethasone (allergic reaction or systemic fungal infection) Known history of allergic reaction to Cremophor-paclitaxel, carboplatin, Azo-Colourant Tartrazine (also known as FD&C Yellow 5 or E102), Azo-Colourant Orange Yellow-S (also known as FD&C Yellow 6 or E110) or known contraindications to any study supplied drug. Known history of allergic reaction to cremophor-paclitaxel, carboplatin, Azo-Colourant Tartrazine (also known as FD&C Yellow 5 or E102), Azo-Colourant Orange Yellow-S (also known as FD&C Yellow 6 or E110) or known contraindications to any study supplied drug. Known allergic reaction to any component of MEDI1873 Prior allergic reaction to cetuximab History of significant adverse or allergic reaction to any component of G100 and, if enrolled in Part 2, anti-PD1 antibodies. Patients must not have a known allergic reaction to epoetin alfa (Procrit) or human serum albumin History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy Prior allergic reaction to the study drugs. Prior allergic reaction to the study drugs involved in this protocol Known allergy or past administration reaction including infusion related reaction (IRRs), anaphylactic, or anaphylactoid reactions to any component of the CDX-0158 formulation. Known major adverse reaction/event in connection with previously made vaccination (e.g. asthma, anaphylaxis or other serious reaction) Has prior allergic reaction to bevacizumab History of allergic reaction to parenteral administered recombinant protein product Prior allergic reaction to the study drugs (cisplatin, mitomycin, fluorouracil [5FU]) involved in this protocol Any history of allergic reaction to paclitaxel or other taxanes, or to carboplatin; Prior allergic reaction to the drugs involved in this protocol Patients with history of allergic reaction to metformin Patients with history of allergic reaction to minocycline or to any of the tetracyclines Prior allergic reaction to temozolomide Prior allergic reaction to 5-FU or oxaliplatin History of >= grade 3 allergic reaction to mFOLFOX6 (patients successfully desensitized to oxaliplatin are eligible or those willing to undergo desensitization during the first two cycles of mFOLFOX6 per institutional guidelines) History of an allergic reaction or intolerance to irinotecan History of allergic reaction (including erythema nodosum) to lenalidomide Prior allergic reaction or severe intolerance to either irinotecan or temozolomide History of allergic reaction to docetaxel History of allergic reaction to disulfiram Any known contraindications to sorafenib including allergic reaction, pill-swallowing difficulty, uncontrolled hypertension or history of cardiac disease, significant gastrointestinal (GI) bleed within 30 days, metastatic brain disease, renal failure requiring dialysis Prior allergic reaction to temozolomide. Prior allergic reaction to the study drug (bevacizumab) Hypersensitivity to the active substance or to any of the excipients for study drug BT062, or history of severe allergic or anaphylactic reaction to therapeutic proteins (e.g. reaction to vaccination or to biological therapy) Known history of allergic reaction to cremophor/paclitaxel Significant allergic reaction to iodinated contrast Prior allergic reaction to trastuzumab for the treatment of metastatic breast cancer Prior allergic reaction to the study drugs involved in this protocol History of allergic reaction to ATRA History of allergic reaction to dasatinib Patients who have previously been administered basiliximab or who have had an allergic reaction to basiliximab or one of its components in the past will be excluded History of serious allergic reaction, including anaphylaxis and toxic epidermal necrolysis Known contraindication to standard-of-care sorafenib including allergic reaction, pill swallowing difficulty, uncontrolled hypertension or history of cardiac disease, significant GI bleed within 30 days, renal failure including dialysis History of allergic reaction to a structural compound or biological agent similar to TH-302 Prior allergic reaction to the study drug(s) involved in this protocol History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy History of serious allergic reaction to yeast or yeast-derived products, including known or suspected hypersensitivity reaction to sargramostim; Experienced a Grade 3 or higher hypersensitivity reaction to monoclonal antibodies or other therapeutic proteins, and the reaction could not be controlled or prevented on subsequent infusion with standard therapies such as antihistamines, 5-hydroxytryptamine (5-HT3) receptor antagonists, or corticosteroids; History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy History of severe (Grade 3 or 4) allergic or hypersensitivity reaction to therapeutic antibodies that required discontinuation of therapy History of severe (Grade 3 or 4) allergic or hypersensitivity reaction to therapeutic antibodies that required discontinuation of therapy Documented allergic or acute hypersensitivity reaction attributed to antibody treatments History of an allergic reaction to Human Serum Albumin History of severe allergic or hypersensitivity reaction to other therapeutic antibodies that required discontinuation of therapy Prior confirmed allergic reaction (including moderate rash, dyspnea, wheezing, urticaria or other symptoms) attributed to the administration of either anthracyclines or other liposomally encapsulated drugs that required discontinuation of prior therapy. Patients with known allergic reaction to lamivudine or tenofovir DF Known allergic reaction to nickel History of allergic reaction to ivabradine Patients with a history of allergic reaction to ropivacaine or other local amide anesthetics History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation Porphyria (possibility of triggering a porphyric reaction) No history of (H/O) allergic reaction to iron therapy Allergic to yogurt History of drug sensitivity or allergic reaction to alpha- or beta-blockers Prior allergic reaction to memantine (memantine hydrochloride) History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation or to latex Patients with a history of clinically significant cutaneous drug reaction, hypersensitivity reaction, anaphylaxis or any other serious adverse reaction to any of the anesthetics or analgesics medications used in the study Patients with a history of clinically significant cutaneous drug reaction, hypersensitivity reaction, anaphylaxis, or any other serious adverse reaction to the medication used in the study Patient with known allergic or hypersensitivity reaction to rHUPH20 or any hyaluronidase extracts Allergic reaction to carbamazepine or oxcarbazepine (major histocompatibility complex, class I, B [HLA-B]*1502) History of allergic or other adverse reaction to venlafaxine or SSRI’s Patients with a history of a severe allergic reaction (anaphylaxis) History of drug sensitivity or allergic reaction to alpha or beta-blockers History of significant adverse reaction or major bleeding related adverse reaction to other anticoagulant or antiplatelet agents History of severe allergic reaction to obinutuzumab A history of adverse reaction to IV thiamine Not be allergic to any cruciferous vegetables (e.g.: broccoli, cauliflower, kale, brussels sprouts, arugula/rocket, bok choy, etc.) History of hypersensitivity or allergic reaction to varenicline, NRT, or any component of these formulations Allergic reaction to omeprazole Allergic reaction to vitamin D Allergic reaction to metformin Any known allergic reaction to vaccine components Patients with a known history of allergic reaction to ethanol, nitroglycerin, or citrate life threatening allergic reaction to food and/or drugs History of reaction to ICG, iodides, or technetium radiocolloid Patient not able to tolerate MRI scan due to claustrophobia or severe pain or allergic reaction to contrast Patients with renal failure or history of allergic reaction to Gadavist will be excluded Known history of allergic reaction to magnetic resonance (MR) contrast material Participants with multiple drug allergies, and/or subjects who have had an allergic reaction to any intravenous iron replacement product, or a known history of hypersensitivity to ferumoxytol Previous allergic reaction to contrast medium Allergic to common dentifrice ingredients Subjects with multiple drug allergies and/or subjects who have had an allergic reaction to any intravenous iron replacement product or a known history of hypersensitivity to ferumoxytol Subjects with multiple drug allergies and/or subjects who have had an allergic reaction to any intravenous iron replacement product or a known history of hypersensitivity to ferumoxytol Patients with a history of allergic reaction to latex or gadolinium containing intravenous contrast agents History of severe allergic/hypersensitivity reaction or significant transfusion reaction. Patients who have had an adverse reaction to oxytocin Women with hypersensitivity to phenylmethane compounds, or a history of allergic reaction to iodides History of allergic reaction to MR contrast media History of allergic reaction to compounds of similar composition to ferumoxytol (e.g. IV iron) History of severe allergic-like reaction to iodinated contrast media