Known hypersensitivity to 5-fluorouracil/leucovorin Patients with a known hypersensitivity to the combination/comparator agent Patients must not have any history of hypersensitivity to any drugs or metabolites of midostaurin Patients with known hypersensitivity to any TZD oral agents are not eligible Patients with a history of hypersensitivity reactions to prior chemotherapy administered for previous cancer diagnoses are eligible to participate in the study, unless the hypersensitivity reaction consisted of anaphylaxis not amenable to desensitization Patients with a history of hypersensitivity to nickel History of hypersensitivity to any of the additives in the alectinib drug formulation Hypersensitivity to carboplatin or cisplatin Patients with history of hypersensitivity to liposomal products Patients with a known hypersensitivity to the combination/comparator agent Hypersensitivity to taxanes (such as Steven Johnson syndrome). Hypersensitivity, such as rash < Grade 3 that is managed, is allowed. Patients with a known hypersensitivity to carboplatin Hypersensitivity to: Known hypersensitivity to afatinib, cisplatin, or pemetrexed No history of severe hypersensitivity reaction to Cremophor EL Known hypersensitivity to platinum compounds Those with porphyria or with known hypersensitivity to porphyrins or porphyrin-like compounds Documented hypersensitivity reaction to any product with GSE History of severe hypersensitivity reactions to cisplatin or vinblastine or other products of the same class; History of hypersensitivity to sertraline History of severe hypersensitivity reactions, which in the opinion of the investigator may cause in increased risk of serious infusion reaction. Patients with porphyria or hypersensitivity to porphyrin or porphyrin-like compounds Known hypersensitivity to the metal in the electrodes (stainless steel 304 L) that cannot be medically managed Part B only: Hypersensitivity to study drugs given in combination with LY3023414 Known hypersensitivity to methotrexate Known hypersensitivity to bortezomib, ixazomib, dexamethasone, or ONC201 The patient has known hypersensitivity to gelatin or lactose monohydrate History of hypersensitivity or idiosyncratic reactions to amide-type local anesthetics or opioids. Known hypersensitivity to the device constituent or TARIS Inserter materials. Has known hypersensitivity to either the drug substances or inactive ingredients in the drug product Known hypersensitivity/intolerance to capecitabine, infusional 5-flurouracil, or bevacizumab Subjects who have hypersensitivity to decitabine, CDX-1401, poly-ICLC or nivolumab Previous hypersensitivity to rapamycin or rapamycin derivatives Carotid sinus hypersensitivity syndrome. History of clinical hypersensitivity to the immunotherapy proposed for combination treatment. A history of sun hypersensitivity or photosensitive dermatitis. History of hypersensitivity to IP or comparator agents Has known hypersensitivity to baker's yeast History of hypersensitivity to thyrotropin alpha (Thyrogen) Known hypersensitivity to Avidin or AvidinOX (e.g. hen egg) Patients with known contraindications to radiotherapy including inherited syndromes associated with hypersensitivity to ionizing radiation (e.g., ataxia telangiectasia, Nijmegen breakage syndrome) History of hypersensitivity to the combination or comparator agent (if applicable) Patients will not be eligible if they have a history of hypersensitivity to tranexamic acid History of hypersensitivity to the combination or comparator agent Documented hypersensitivity to bumetanide or sulfonamides Has hypersensitivity to nivolumab or any other drug used in this protocol Known or suspected intolerance or hypersensitivity to IT-141 or any of the stated ingredients. Patients who have a history of ataxia telangiectasia or other documented history of radiation hypersensitivity Known hypersensitivity or intolerance to any of the agents under investigation History of hypersensitivity to paclitaxel, not attributed to a hypersensitivity type reaction to Cremophor®, or history of hypersensitivity type reaction to polysorbate 80 or other components of the formulation of Oraxol Patients with inherited syndromes associated with hypersensitivity to ionizing radiation, specifically patients with known history of ataxia-telengiectasia, Nijmegen breakage syndrome Known hypersensitivity to deferasirox Known hypersensitivity to S-1 or its metabolites (eg, 5-FU); History of hypersensitivity to any of the kinase inhibitors included in this study History of hypersensitivity to the combination or comparator agent History of hypersensitivity to hydrogel. History of hypersensitivity to tremelimumab or the combination of MEDI4736 + tremelimumab Hypersensitivity to simvastatin or ezetimibe. Patients with known hypersensitivity to taxanes or platinums are to be excluded A history of hypersensitivity to selumetinib, or any excipient agents (e.g. Captisol or TPGS- a water soluble form of Vitamin E) Prior unanticipated severe reaction to fluoropyrimidine therapy or known hypersensitivity to 5–fluorouracil History of allergy or untoward reaction to yeast-based products (any hypersensitivity to yeast-based products will be excluded) Patients with a known hypersensitivity to interferon-alpha Known hypersensitivity to 5-FU injection, poor nutritional state, known dipyrimidine dehydrogenase deficiency, or taking sorivudine (such as Usevir, Bravavir, etc.) Subjects with history of hypersensitivity to azoles Patients with known hypersensitivity to pegfilgrastim and filgrastim Anergic, defined by the inability to make a Delayed-type Hypersensitivity (DTH) to at least one of the following: candida, mumps, tetanus or trichophyton (based upon availability) Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds Hypersensitivity of TZD Known hypersensitivity or other serious adverse reaction to any azole antifungal therapy or to any other ingredient of the study medication used. Hypersensitivity to mithramycin History of hypersensitivity to vemurafenib Patients with history of hypersensitivity to conductive hydrogel are not eligible Patients who are (MVF-HER-2[266-296] and MVF-HER-2 [597-626]) immediate hypersensitivity skin test positive Known severe hypersensitivity to trastuzumab (excluding mild to moderate infusion reactions that are easily managed and do not recur) Have a history of hypersensitivity to dacarbazine (DTIC) History or presence of hypersensitivity or idiosyncratic reaction to deferiprone or deferoxamine; Hypersensitivity to fluphenazine or other phenothiazines Hypersensitivity to any reagents used in the study. Known hypersensitivity to enzalutamide Hypersensitivity to acetazolamide or sulfonamides Has known serious hypersensitivity reactions to peg-interferon alfa-2b or interferon alfa-2b Known hypersensitivity or intolerance to any of the agents under investigation Known hypersensitivity to arsenic trioxide History of hypersensitivity to the combination or comparator agent (If applicable) Known hypersensitivity to Cremophor®-based agents No known hypersensitivity to Escherichia (E.) coli-derived products Patients with a prior hypersensitivity reaction to sargramostim The subject has a history of hypersensitivity reaction to temozolomide or a history of hypersensitivity to dacarbazine (DTIC) Patients with a known hypersensitivity to gemtuzumab ozogamicin or its parts: recombinant humanized anti-CD33 monoclonal (hP67.6) antibody, calicheamicin derivatives or other ingredients TREATMENT: Patients with known hypersensitivity reaction to dacarbazine are ineligible to receive temozolomide Patients with known contraindications to radiotherapy, including inherited syndromes associated with hypersensitivity to ionizing radiation (e.g., ataxia-telangiectasia, Nijmegen breakage syndrome) Hypersensitivity to mithramycin Known hypersensitivity to inactive ingredient of TPI 287 History of hypersensitivity to dacarbazine Hypersensitivity to trial medications (everolimus) Hypersensitivity to any of the study medications Patients with known hypersensitivity to temozolomide or dacarbazine are not eligible Serious hypersensitivity reaction to egg products A history of ataxia telangiectasia or other documented history of radiation hypersensitivity Patients who have hypersensitivity to sitagliptin Patients with previous hypersensitivity reaction to camptothecins are excluded Documented hypersensitivity to clobetasol Must not have known hypersensitivity to 4-aminoquinoline compound Patients with a known hypersensitivity to BKM120, RAD001 (including other rapalogs) or their excipient Hypersensitivity to interferon alfa Suspected hypersensitivity to IFN alfa2b Patient must not be known to have hypersensitivity to TAK-700, to TAK-700 metabolites, to bicalutamide, or to LHRH agonist Patients with known Aspirin-Hypersensitivity triad (asthma, allergic rhinitis, ASA hypersensitivity). History of intolerance or hypersensitivity to study drug Subject has a history of hypersensitivity to porcine derived gelatin or collagen. Subject has a history of hypersensitivity to microbial Transglutaminase. Known history of immunogenicity or hypersensitivity to a CD25 antibody. Has a history of severe hypersensitivity reaction (e.g., generalized rash/erythema, hypotension, bronchospasm, angioedema or anaphylaxis) to axitinib or sunitinib. Hypersensitivity or prior treatment with obinutuzumab Known hypersensitivity to the study treatment or any of its ingredients. Known history of immunogenicity or hypersensitivity to a CD19 antibody. Intolerance or hypersensitivity to octreotide Known hypersensitivity to 5-fluorouracil/leucovorin Prior treatment with or hypersensitivity to study drug or related compounds Known hypersensitivity to bicalutamide. Hypersensitivity to cytarabine, daunorubicin or liposomal products Patients with known hypersensitivity to any TZD oral agents are not eligible History of hypersensitivity to LCI699 or to drugs of similar chemical classes. Immediate or delayed hypersensitivity to digoxin or trametinib Patients who have exhibited hypersensitivity reactions to regorafenib and/or a structural compound, biological agent, or formulation (e.g., sorafenib) History of hypersensitivity to any of the additives in the alectinib and crizotinib drug formulation History of hypersensitivity to anakinra. History of hypersensitivity to everolimus. History of hypersensitivity to castor oil Immediate or delayed hypersensitivity to digoxin History of hypersensitivity to TPIV200 Hypersensitivity to pegfilgrastim or Escherichia (E.) coli derived proteins Known hypersensitivity to enzalutamide or related compounds Subject has a known hypersensitivity to platinum compounds. Known hypersensitivity to everolimus or bendamustine Documented hypersensitivity to any of the drugs used in the protocol Subject has a known hypersensitivity to platinum compounds. Known intolerance or hypersensitivity to vitamin E, everolimus or to rapamycin derivatives Known hypersensitivity to 5-fluorouracil/leucovorin Known hypersensitivity to capecitabine Known hypersensitivity to cytarabine, daunorubicin or liposomal products Known hypersensitivity to any immunomodulatory drugs (IMiDs), including Grade 4 rash Known hypersensitivity or intolerance to dexamethasone Patients must not have known hypersensitivity reactions, such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Steven-Johnson syndrome, and toxic epidermal necrolysis to interferon alpha or any other products component Known hypersensitivity to both allopurinol and rasburicase History of hypersensitivity to any compound in the tetracycline antibiotics group Steroids for the treatment of hypersensitivity or transfusion reactions. Prior history of infusion reactions or hypersensitivity to any of the study drugs Known hypersensitivity reaction to mushroom products Patients with a known hypersensitivity to tacrolimus Patients with known hypersensitivity to Escherichia coli (E.coli)-derived proteins, filgrastim, or any component of filgrastim are not eligible History of hypersensitivity to ipilimumab Known anaphylactic or severe hypersensitivity to dasatinib or crizotinib or their analogs Hypersensitivity to cytarabine, daunorubicin or liposomal products Patients with known hypersensitivity to rapamycins No known hypersensitivity to 4-aminoquinoline compound Patients with hypersensitivity to any tetracyclines Known hypersensitivity reaction or idiosyncrasy to erlotinib No known hypersensitivity to ofatumumab, humanized antibodies or chemotherapy agents throughout the protocol Patients who have had a hypersensitivity reaction to polyoxyethylated or hydrogenated castor oil A history of ataxia telangiectasia or other documented history of radiation hypersensitivity Known hypersensitivity to any of the following: diphtheria toxoid, neomycin, polymyxin B, streptomycin, 2 phenoxyethanol, formaldehyde, aluminum hydroxide, yeast Known hypersensitivity to fluoropyrimidines or cisplatin. History of hypersensitivity to sirolimus History of hypersensitivity to vorinostat History of hypersensitivity to hydroxychloroquine Prior carboplatin or cisplatin hypersensitivity reaction Any history of adverse reaction or hypersensitivity to LDAC Known history of hypersensitivity to aromatase-inhibitor drugs Patients with known hypersensitivity to any oligodeoxynucleotide that cannot be adequately managed with appropriate prophylaxis; e.g. steroids. Prior treatment with or have known hypersensitivity to AL3818. b. Indication B- LMS: Prior treatment with or have known hypersensitivity to dacarbazine. c. Indication C - SS: Prior treatment with or have known hypersensitivity to dacarbazine. History of hypersensitivity to tremelimumab Has known hypersensitivity to baker's yeast History of Grade ? 3 infusion-associated AEs or hypersensitivity to another monoclonal antibody, or known hypersensitivity to diphenhydramine or acetaminophen Subject has known history of serious hypersensitivity reaction to a known ingredient of ASP8273, erlotinib or gefitinib. Prior treatment with TAS4464 or known hypersensitivity to any of its inactive ingredients or drugs similar in class Known history of ? Grade 3 hypersensitivity to a therapeutic antibody. History of hypersensitivity to the combination or comparator agent Known hypersensitivity to filgrastim or to Escherichia coli (E. coli) derived proteins Known hypersensitivity to any constituent of the study medication. History of hypersensitivity to 4-aminoquinoline compound Known hypersensitivity to 5-azacytidine\r\n* Prior treatment with 5-azacytidine is allowed Known hypersensitivity to dacarbazine (DTIC). Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds Known hypersensitivity to any inactive ingredient of TPI 287 Hypersensitivity to tea products or any of the inactive ingredients found in the drug product capsules Known hypersensitivity to lithium or tretinoin Has a known hypersensitivity to baker's yeast or has an active yeast infection; Patients with hypersensitivity to amiodarone or NAC Hypersensitivity to obinutuzumab Patients with known hypersensitivity or intolerance to melphalan Subjects with porphyria’s or known hypersensitivity to porphyrins There are no known contra-indications to any of the planned agents used in this protocol; etoposide may be substituted by etoposide phosphate (Etopophos) if the patient has a history of hypersensitivity reaction to etoposide Known hypersensitivity to rosuvastatin Hypersensitivity to cytarabine, daunorubicin or liposomal products Known intolerance of or hypersensitivity to fosbretabulin Known hypersensitivity to filgrastim, plerixafor, or Escherichia (E.) coli derived products Known hypersensitivity to any of the treatment ingredients. Known previous Grade 3-4 infusion related reactions with anti-EGFR mABs Have known hypersensitivity to platinum (Pt) compounds History of hypersensitivity to hydrogel Hypersensitivity to recombinant human IL-2 Known hypersensitivity to Tween-80, or human immunoglobulin Known hypersensitivity to study-assigned chemotherapy Hypersensitivity to 4-aminoquinoline compounds, including hydroxychloroquine sulfate, chloroquine phosphate and amodiaquine History of hypersensitivity to amikacin or other aminoglycosides Subjects with known hypersensitivity to peptide drugs, including LHRH agonists. History of hypersensitivity to taxanes or drug formulations containing Cremophor®. Known hypersensitivity to varenicline Prior history of a hypersensitivity reaction to PLD, doxorubicin, bortezomib, carfilzomib, or liposomal drug formulations other than PLD Suspected hypersensitivity to interferon alpha Hypersensitivity to trial medications Known hypersensitivity to other Src/Abl non-receptor kinase inhibitors. Hypersensitivity to cytarabine, daunorubicin or liposomal products History of severe hypersensitivity reaction to capecitabine, 5-FU, temozolomide or DTIC will be excluded (i.e. anaphylaxis or anaphylactoid reactions) Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds Have known hypersensitivity to ciprofloxacin or any member of the quinolone class of antimicrobial agents, Have a known hypersensitivity to olanzapine or to phenothiazines History of hypersensitivity to other psychostimulants Patients known to have hypersensitivity to dacarbazine (DTIC) are not eligible Known hypersensitivity (example, anaphylactic and anaphylactoid reactions) to any particular combination drug will result in a participant being ineligible for inclusion in that particular cohort. Known hypersensitivity to cold History hypersensitivity to opioids. History of hypersensitivity or reaction to N-methyl-D-aspartate (NMDA) receptor antagonists PATIENTS: History of hypersensitivity to haloperidol or chlorpromazine Patients with hypersensitivity to ropivacaine/amide-type anesthetics Patient has a known hypersensitivity to the administration of any prescribed oral or intravenous study medication or metabolite, including but not limited to, a history of hypersensitivity to the drugs or their components, severe renal impairment, severe bone marrow suppression, or systemic infection Hypersensitivity to pregabalin History of hypersensitivity to pregabalin or gabapentin History of hypersensitivity or severe intolerance to azoles Hypersensitivity to ginseng Patients with known hypersensitivity to octreotide or somatostatin Patients with a history of echinocandin or fluconazole hypersensitivity are not eligible Patients with a history of echinocandin or azole hypersensitivity are not eligible History of hypersensitivity to all of the following antibiotics: penicillin, erythromycin, clindamycin, and any fluoroquinolone Patients with hypersensitivity to any tetracycline History of hypersensitivity to haloperidol or benzodiazepine Patients with hypersensitivity to tetracyclines Minocycline trial only: patients with hypersensitivity to any tetracyclines No history of severe hypersensitivity reactions to drugs or other causes (e.g., beestings) Patients with known hypersensitivity to sildenafil or other ingredients of sildenafil Subjects with a history of hypersensitivity or idiosyncratic reactions to azole agents History of hypersensitivity to sulfur hexafluoride lipid microsphere components or to any of the inactive ingredients in Lumason Previous documented history of moderate to severe hypersensitivity to Gd contrast agents Previous medical history of, or suspected hypersensitivity to, the Methylene Blue and/or formulations' ingredients. Previous medical history of, or suspected hypersensitivity to, the PEG based bowel cleansing preparation and/or bowel cleansing formulations' ingredients. History of hypersensitivity to previous influenza vaccination or severe or moderate hypersensitivity to eggs/egg protein History of known latex hypersensitivity Known hypersensitivity or history of hypersensitivity to dimethylsulfoxide (DMSO) History of hypersensitivity to previous influenza vaccination or severe or moderate hypersensitivity to eggs/egg protein History of known latex hypersensitivity History of hypersensitivity or idiosyncratic reactions to azoles Known hypersensitivity to NAC Patients who have hypersensitivity to sitagliptin Known hypersensitivity to cyclophosphamide or any of its metabolites History of hypersensitivity reaction to Xolair or any ingredient of Xolair History of hypersensitivity to taxanes; hypersensitivity to the solvent does not preclude patient participation in this Study History of hypersensitivity or unexpected reactions to capecitabine, other fluoropyrimidine agents, or any of their ingredients Has suspected or known hypersensitivity to ingredients of MK-8228 (letermovir) formulations Subjects with a known hypersensitivity to calcitriol The patient has a known hypersensitivity to Lymphazurin or Lymphoseek Individuals with history of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis HEALTHY VOLUNTEER: Known hypersensitivity to UCAs History of hypersensitivity to nickel History of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis Hypersensitivity to iodide products Hypersensitivity to dextran and/or modified form thereof Previous hypersensitivity reaction to LAR octreotide Hypersensitivity or anaphylactic reaction to any somatostatin analog or to maytansinoids Patients with history of hypersensitivity reaction to any component of 89Zr-DFO-MSTP2109A, including DFO The subject has a known hypersensitivity to Isosulfan Blue Dye. Known hypersensitivity to zolpidem or chemically related compounds; history of serious adverse reactions or hypersensitivity to any drug EXCLUSION CRITERIA - FOR NORMAL HEALTHY FEMALE COHORT: Known hypersensitivity to zolpidem or chemically related compounds; history of serious adverse reactions or hypersensitivity to any drug Patients with known hypersensitivity including anaphylaxis to trabectedin Known hypersensitivity or intolerance to itraconazole or similar class agents. Patients must not have any known contraindication to CSFs prior to registration, including prior hypersensitivity to Escherichia coli-derived proteins, filgrastim, pegfilgrastim, or tbo-filgrastim Hypersensitivity to Caphosol ingredients The patient received omacetaxine or has a history of hypersensitivity. Patients with a history of hypersensitivity to nickel. Known hypersensitivity to tartrazine, a dye used in the ensartinib 100 mg capsule. History of hypersensitivity to paclitaxel, not attributed to a hypersensitivity type reaction to Cremophor Known history of immunogenicity or hypersensitivity to a CD19 antibody.