Major surgery within 28 days of the first dose of study drug Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks before the first dose of study drug Major surgery within 28 days prior to initiation of study drug. Major surgery within 2 months before planned first dose of study drug Prior major treatment-related surgery completed at least 4 weeks prior to study drug administration; Major surgery within 2 weeks of the first dose of study drug Has had major surgery within 4 weeks before first study drug administration Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of first dose of study drug Any major surgery within 4 weeks prior to the first dose of study drug. Major surgery or radiation therapy within 14 days before study drug administration CRITERIA SPECIFIC FOR COHORT #2 (MCL): Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of first dose of study drug Major surgery within 2 weeks prior to first dose of study drug Major surgery within 14 days before the first dose of any study drug or a scheduled surgery during the study period Major surgery within 4 weeks of initiation of study drug Major surgery within 28 days prior to first dose of study drug Major surgery within 14 days before the first dose of any study drug or a scheduled surgery during study period Major surgery within 2 weeks prior to registration or first dose of drug Subject has had major (per Investigator discretion) surgery, with the exception of tumor resection, within 21 days from first dose of study drug. Major surgery (including opening of the abdomen, chest, or skull) within 21 days of the first dose of study drug. Major surgery within 2 weeks prior to first dose of study drug Major surgery within 2 weeks of first dose of study drug Undergone major surgery within 14 days of the initial dose of study drug Major surgery (eg, nephrectomy) less than 28 days prior to the first dose of study drug Major surgery within 4 weeks of initiation of study drug Major surgery less than 6 weeks prior to the first dose of study drug; minor surgery less than 4 weeks prior to the first dose of study drug Major surgery (eg, nephrectomy) less than 28 days prior to the first dose of study drug Major surgery within 4 weeks of first dose of study drug Major surgery within 14 days before the first dose of any study drug or a scheduled surgery during study period Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks before first dose of study drug Major surgery within 4 weeks of first dose of study drug Subjects who have had major surgery (such as nephrectomy) or chemotherapy within 2 weeks prior to first dose of drug Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of drug administration Major surgery within 14 days before the first dose of study drug Major surgery within 14 days before the first dose of study drug and have not recovered fully from any complications from surgery. Had major surgery within 4 weeks prior to study drug treatment. Major surgery within 4 weeks of first dose of study drug Major surgery within 14 days before the first dose of any study drug or a scheduled surgery during study period Major surgery, other than diagnostic surgery, within 4 weeks prior to the first dose of test drug. Major surgery within 4 weeks of first dose of study drug Subjects who have had major surgery within 2 weeks prior to first dose of drug Major surgery within 28 days of the first dose of study drug Major surgery within 8 weeks of study enrollment or planned major surgery during study and up to 6 months after discontinuation of study drug Major surgery within 4 weeks of first dose of study drug Has had major surgery to liver or other site within 4 weeks prior to the first dose of study drug. Major surgery within 4 weeks prior to first dose of study drug. Major surgery within 4 weeks before first dose of study drug. Major surgery within 4 weeks before first dose of study drug. major surgery within 4 weeks of first dose of study drug Major surgery within 28 days prior to first dose of study drug Major surgery within 4 weeks of the first dose of study drug Major surgery within 4 weeks of first dose of study drug Major surgery, within 28 days of first dose of study drug Major surgery within 4 weeks before the first dose of study drug. Major surgery within 28 days of study drug Have had major surgery (excluding biopsy) < 28 days of the initial dose of study drug. Major surgery within 4 weeks of first dose of study drug. Major surgery within 4 weeks of first dose of study drug Major surgery within 14 days before first dose of study drug Major surgery within six weeks or open biopsy within 14 days before drug infusion. Trauma or major surgery within 4 weeks of first study drug administration Major surgery within 4 weeks of first dose of study drug Major surgery within 2 weeks of study drug administration Had major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of the first dose of study drug. Major surgery within 4 weeks prior to first study drug administration Subjects that have undergone major surgery within 4 weeks prior to the first dose of study drug are not eligible At least 4 weeks must have elapsed from major surgery prior to starting study drug No major surgery within the last 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug Major surgery within 4 weeks before first dose of study drug. Major surgery within the 28 days preceding the first dose of study drug Major surgery within 3 weeks before the first dose of study drug. Major surgery within 14 days before the first dose of study drug Major surgery or radiation therapy within 4 weeks before first study drug administration. Major surgery planned within 4 weeks of the first dose of study drug Major surgery within 3 weeks prior to first study drug administration. Major surgery within 14 days prior to the first dose of study drug Major surgery within 28 days prior to the first dose of study drug. Major surgery within 4 weeks of 1st dose of study drug Major surgery within 28 days prior to the first dose of study drug. Major surgery within 4 weeks of first dose of study drug. Major surgery within 28 days of first dose of study drug 9. Major surgery within 28 days prior to the first dose of study drug. Major surgery within 4 weeks of initiation of study drug Major surgery within six weeks or open biopsy within 14 days before drug infusion. Major surgery ? 21 days from beginning of study drug Major surgery within 14 days before the first dose of study drug. Major surgery within 2 weeks before the first dose of either study drug Major surgery within 28 days before the first dose of study drug Prior major surgery or trauma within 28 days before first dose of study drug Major surgery within 14 days before the first dose of study drug Major surgery or radiotherapy within 14 days before study drug administration Major surgery within 14 days before the first dose of study drug Major surgery or significant trauma within 2 weeks prior to the first dose of study drug. Major surgery or radiotherapy within 14 days before the first dose of study drug Has major surgery or radiotherapy within 14 days before the first dose of study drug Major surgery within 14 days of initiation of study drug treatment The subject has had prior major surgery within 30 days prior to first dose of study drug Major surgery within 14 days before the first dose of study drug or incomplete recovery from any complications from surgery. Major surgery within 14 days before the first dose of study drug and not recovered fully from any complications from surgery. Prior major surgery within 4 weeks of starting study drug administration Trauma or major surgery within 4 weeks of first study drug administration Major surgery within 28 days prior to first dose of study drug. Major surgery within 4 weeks of first dose of study drug Major surgery within 4 weeks of first dose of study drug EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Major surgery within 4 weeks of first dose of study drug Had major surgery within 4 weeks before study drug treatment Major surgery within 4 weeks of first dose of study drug History of severe trauma or major surgery within 4 weeks prior to the initiation of study drug administration. Major surgery within 28 days of first drug dose Major surgery within 14 days before the first dose of study drug and not recovered fully from any complications from surgery. Major surgery within 14 days before the first dose of study drug and not recovered fully from any complications from surgery. Major surgery within 14 days before the first dose of study drug and not recovered fully from any complications from surgery.