Major surgery within 30 days prior to enrollment. Major surgery ?28 days or major radiation therapy ?14 days prior to enrollment. Major surgery within 4 weeks of enrollment Major surgery within 14 days before enrollment Major surgery within 6 weeks of enrollment Major surgery within 14 days before enrollment Major surgery within 4 weeks before enrollment Major surgery within 14 days before enrollment Prior chemotherapy and/or immunotherapy within 14 days before enrollment; major surgery within 14 days before enrollment and minor surgery within 7 days prior to cycle 1 day 1 Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Patients with major surgery within 28 days prior to trial enrollment Major surgery within 1 month prior to enrollment Major surgery within 28 days of enrollment. Patients who had undergone any major surgery within 4 weeks of study enrollment Major surgery within 4 weeks prior to enrollment Major surgery within 2 months before enrollment; complete healing from major surgery must have occurred 1 month before enrollment; complete healing from minor surgery (eg, simple excision, tooth extraction) must have occurred at least 7 days before enrollment; subjects with clinically relevant complications from prior surgery are not eligible Major surgery within 14 days before enrollment Major surgery within 4 weeks of enrollment Any major surgery within 21 days prior to enrollment Prior major surgery or gastrointestinal perforation within 28 days of enrollment No major surgery within 4 weeks prior to enrollment Major surgery: only patients who are not anticipated to need major surgery within the next 3 months of enrollment are eligible Major surgery* within 28 days before enrollment. Major surgery within 1 month prior to enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment At least 30 days from major surgery before study enrollment, with full recovery Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Has had major surgery within 3 weeks prior to enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Surgery within 3 weeks prior to enrollment Major surgery within 21 days prior to enrollment Must have had no major surgery within 28 days prior to enrollment. Patients who have had major surgery within 6 weeks of enrollment in the study Major surgery within 14 days before enrollment. Major surgery within 30 days prior to enrollment. Major surgery within 4 weeks prior to study enrollment. Major surgery within 1 month prior to enrollment. Patients who have undergone major surgery within 4 weeks prior to study enrollment Major surgery within 14 days before enrollment Has had major surgery within 2 weeks prior to enrollment Major surgery or trauma within four weeks before enrollment. Have had any major surgery within four weeks of enrollment. Prior chemotherapy, radiotherapy, biological cancer therapy or major surgery within 28 days prior to enrollment Major surgery within 4 weeks prior to enrollment Patients that have undergone major surgery within the last 4 weeks before enrollment; Have an elective or a planned major surgery during the course of the trial or has undergone major surgery within 28 days prior to enrollment. Major surgery within 30 days prior to enrollment. Major surgery within 4 weeks of enrollment Major surgery within 4 weeks of enrollment Major surgery within 14 days prior to enrollment Last surgery > 10 weeks from enrollment Surgery less than two weeks before enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Has had major surgery within 28 days prior to enrollment Patients who have undergone major surgery within 2 weeks prior to study enrollment or who have not recovered from a major surgery COHORT A: Major surgery within 4 weeks of enrollment (week 1 visit) COHORT B: Major surgery within 4 weeks of enrollment (week 1 visit) Prior major surgery less than 14 days prior to enrollment. Any surgery-related AE(s) must have resolved prior to enrollment Major surgery within 1 month prior to enrollment. Major surgery within 4 weeks prior to study enrollment. No major surgery within 4 weeks prior to enrollment Major surgery or radiation therapy within 4 weeks of enrollment Patients who have had any major surgery within 21 days prior to enrollment Major surgery within 28 days prior to enrollment or still recovering from prior surgery No major surgery or radiation in the prior 4 weeks prior to enrollment Major surgery within 7 days of enrollment Major surgery within 4 weeks of enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Major surgery within 14 days before enrollment Major surgery within 1 month prior to enrollment Major surgery within 4 weeks prior to study enrollment Prior major surgery or radiation therapy within 4 weeks of enrollment; Patients who have had major surgery within 4 weeks of enrollment Patients who have had major surgery within 14 days of study enrollment Major surgery within 4 weeks of study enrollment Major surgery within 28 days prior to enrollment or still recovering from prior surgery Major surgery ? 28 days prior to enrollment. Prior brain surgery =< 14 days prior to enrollment Major surgery within 28 days prior to enrollment. Major surgery within 28 days prior to enrollment. No major surgery within 2 weeks prior to signing of study enrollment Major surgery within 14 days before enrollment Patient has had major surgery within 14 days prior to enrollment No surgery in the last 2 weeks prior to study enrollment Major surgery, including craniotomy, within 14 days before enrollment Major surgery . 28 days prior to enrollment.