Infection requiring systemic antibiotic therapy or other serious infection within 14 days before registration Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Patients who have an infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment are not eligible Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring intravenous antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring intravenous (IV) antibiotic therapy or other serious infection within 14 days before randomization. Systemic infection requiring intravenous (IV) antibiotic or antifungal or antiviral therapy within 7 days preceding the first dose of study drug, or other severe infection Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study drug administration Infection requiring systemic intravenous antibiotic therapy or other serious infection within 14 days before study enrollment Serious infection requiring parenteral antibiotic therapy or any other serious infection within 14 days before randomization. Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Systemic infection requiring intravenous (IV) antibiotic therapy =< 14 days prior to registration Systemic infection requiring intravenous (IV) antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days prior to start of study treatment Infection requiring systemic IV antibiotic therapy within 7 days before cycle 1 day 1 of therapy Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Systemic infection requiring intravenous (IV) antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment. Infection requiring systemic antibiotic therapy within 14 days prior to the start of study treatment Infection requiring systemic antibiotic therapy or other serious infection ? 7 days prior to registration Systemic infection requiring IV antibiotic therapy within 7 days preceding the first dose of study drug, or other severe infection Systemic infection requiring intravenous (IV) antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Infection requiring systemic antibiotic therapy or other serious infection within 14 days before first dose of study drug Serious infection requiring systemic antibiotic therapy within 14 days prior to study treatment. Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Systemic infection requiring IV antibiotic therapy within 7 days preceding the first dose of study drug, or other severe infection Systemic infection requiring intravenous (IV) antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Infection requiring intravenous (IV) antibiotic therapy or other serious infection within 14 days before randomization. Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Serious infection requiring treatment with systemically administered antibiotics at the time of study entrance, or an infection requiring systemic antibiotic therapy within 7 days prior to the first dose of study treatment. Active clinically serious infection > Common Terminology Criteria for Adverse Events (CTCAE) grade 2 or systemic infection requiring IV antibiotic therapy within 14 days preceding the first dose of study drug Active clinically serious infection > Common Terminology Criteria for Adverse Events (CTCAE) grade 2 or systemic infection requiring IV antibiotic therapy within 14 days preceding the first dose of study drug Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before randomization. Systemic infection requiring IV antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Subject has systemic infection requiring intravenous (IV) antibiotic therapy within 7 days preceding the first dose of study drug, or other severe infection Serious infection requiring intravenous antibiotic therapy within 14 days prior to study treatment Serious infection requiring treatment with systemically administered antibiotics at the time of study entrance, or an infection requiring systemic antibiotic therapy within 7 days prior to the first dose of study treatment. Serious infection requiring treatment with systemically administered antibiotics at the time of study entrance, or an infection requiring systemic antibiotic therapy within 7 days prior to the first dose of study treatment. Infection requiring IV antibiotic therapy or other serious infection within 14 days prior to first dose of study drug Systemic infection requiring IV antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Serious infection requiring treatment with systemically administered antibiotics at the time of study entrance, or an infection requiring systemic antibiotic therapy within 7 days prior to the first dose of study treatment. For the HCC, HCC/BTC and BTC subgroups hepatitis C infection and hepatitis B infection if controlled with antiviral therapy are allowable. Systemic infection requiring intravenous (IV) antibiotic therapy within 14 days preceding the first dose of study drug, or other severe infection Systemic infection requiring parenteral antibiotic therapy or other serious infection (bacterial, fungal, or viral) within 21 days before the first dose of study drug. Systemic infection requiring IV antibiotic therapy or other serious infection within 14 days before the first dose of study drug. Infection requiring systemic antibiotic therapy within 14 days prior to start of study treatment Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment Systemic infection requiring intravenous antibiotic therapy or other serious infection within 14 days before the first dose of study drug.