Able to provide valid written informed consent Able and willing to give valid written informed consent. Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent; in patients who are not able to consent to the trial due to medical circumstances, the next of kin or power of attorney may consent for the study Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent Able to provide valid written informed consent. Able and willing to give valid written informed consent Able and willing to give valid written consent for available archival tumor samples or fresh tumor biopsies/resections Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent Capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent Able and willing to give valid written informed consent. Able and willing to give valid written informed consent Signed written informed consent; patient must be capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent Able and willing to give valid written informed consent Able and willing to give valid written informed consent. Able and willing to give valid written informed consent. Able and willing to give valid written consent for archival tumor samples Able and willing to give valid written consent for biopsy samples (subjects in the expansion phase only). Able and willing to give valid written informed consent. Participant or legal guardian, in the opinion of the investigator, is capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent; a signed informed consent must be obtained prior to any study specific procedures Valid email address Has a valid driver’s license Patients who cannot provide a valid consent RANDOMIZED CONTROLLED TRIAL: Must also have a valid email address Signed written informed consent (patient must be capable of understanding the investigational nature, potential risks and benefits of the study, and able to provide valid informed consent) Patients who because of age, general medical or psychiatric condition, or physiologic status cannot give valid informed consent Patients who because of age, general medical or psychiatric condition, or physiologic status cannot give valid informed consent Patients who because of general medical or psychiatric condition or physiologic status cannot give valid informed consent Patient is able and willing to give valid written informed consent Patients who because of age, general medical or psychiatric condition, or physiologic status unrelated to the presence of prostate cancer are unlikely to be candidates for repeat MRIs, or cannot give valid informed consent Valid informed consent by subject