Able to operate the NovoTTF-100M device independently or with the help of a caregiver Able to operate the NovoTTF-100L device independently or with the help of a caregiver Ability to operate the NovoTTF-200A device independently or with caregiver aid Patient must have an outpatient caregiver available The patient has a caregiver for 28 days after dosing with C. novyi-NT Caregiver: Must be considered the patient's primary caregiver Caregiver: Age >= 18 years The patient has a caregiver for 28 days after dosing. Has a designated parent or caregiver who is willing to enter into a mutual agreement with the patient to participate in a daily supervised medication administration routine Parent/caregiver and patient (if 12 years and older) must be willing to use a cellular telephone to receive medication reminders via text messaging during study period CAREGIVER: Relative or friend who is identified by the patient participant and lives with the patient or has contact with them at least twice per week The patient must have an identified caregiver who is willing and able to oversee the training practice during the intervention period (ie, for 5-9 weeks starting approximately 3 months after completion of CRT) A caregiver of a participating lung cancer survivor\r\n*An enrolled survivor may designate one primary caregiver to participate in the study; (a caregiver cannot participate without an enrolled survivor) PARENT/CAREGIVER: One or both parents self-identify as Hispanic/Latino and the primary participating parent/caregiver is monolingual or bilingual Spanish speaking PATIENT INCLUSION: Have an identified caregiver who is also willing to participate Patient has a spouse/partner other or close family member who he/she defines as the primary caregiver Patient/caregiver can provide informed consent CAREGIVERS: Primary caregiver for study eligible patient A relative or a friend who either lives with the patient or has in-person contact with him or her at least twice per week and is identified as the primary caregiver for transplant CAREGIVER ELIGIBILITY CRITERIA (Caregiver participation) accompanied the patient to the clinic visit (Caregiver participation) is identified by the patient as someone who is actively involved in their overall care CAREGIVER: Family member/friend identified by the patient as the primary caregiver before and after surgery CAREGIVER: >= 21 years Parent/legal guardian/caregiver that speaks English available to assist in participant’s training CAREGIVER: Unpaid individuals involved in assisting the cancer patient with activities of daily living and/or medical tasks PATIENT AND CAREGIVER: Oriented to place, person, and time PATIENT AND CAREGIVER: Have an active telephone service, either cellular or landline A healthcare professional, a patient or caregiver in the Radiation Oncology Department at the University of Pennsylvania Any healthcare professional or patient/caregiver not working in or being seen at Radiation Oncology Department at the University of Pennsylvania PATIENTS: Having an informal family caregiver (spouse, romantic partner, adult child, or sibling) who is willing to participate. If patients do not have one consistent primary caregiver for the duration of the study, they may be accompanied to the yoga sessions by an alternate caregiver who meets eligibility criteria. CAREGIVER: Spouse or cohabitating intimate partner of an advanced cancer patient being evaluated at the University of Pittsburgh Medical Center (UPMC)’s Liver Cancer Center (LCC) CAREGIVER: Evidence of thought disorder, delusions, hallucinations, or suicidal ideation INCLUSION CRITERIA FOR CAREGIVER PARTICIPANTS Self-identifies as partner, spouse or caregiver of a patient who is eligible as a patient participant and who has consented to participate EXCLUSION CRITERIA FOR CAREGIVER PARTICIPANTS The patient for whom they are a caregiver does not consent to participate Must have a caregiver or assistance at home who can assist with collecting physical therapy (PT) measures Caregiver inclusion criteria:\r\n* Adults (>= 21)\r\n* Family member or friend of an eligible patient PHASE 1: PARENT ELIGIBILITY: Caregiver of a pediatric cancer survivor age 18-25 who was primary caregiver at diagnosis As per self-report, a current caregiver to a patient with any site or stage of cancer Adequate caregiver support as defined by:\r\n* Single or multiple informal caregivers willing and able to provide 24 hour a day, seven day a week supervision of the transplant recipient in their home or \home-like\ environment\r\n* Caregiver willing and able to fulfill the basic stem cell transplant caregiver education requirements as determined by caregiver and healthcare team, including social worker Both patient and caregiver willing to give and sign informed consent Inadequate caregiver arrangements CAREGIVER PARTICIPANTS: Can identify at least one primary, adult caregiver CAREGIVER: Can provide Informed consent Lack of a caregiver CAREGIVER: Identified by patient as their primary caregiver Meet standard clinical criteria for being a caregiver (able to drive and take care of patient) Another parent or primary caregiver of the child has been enrolled in the study Lack of a caregiver PATIENTS ONLY: Having an informal caregiver (spouse, romantic partner, adult child, sibling, or friend) who is willing to participate; if patients do not have one consistent primary caregiver for the duration of the study, they may be accompanied to the yoga sessions by an alternate caregiver who meets eligibility criteria Availability and willingness of a parent or caregiver to deliver acupressure for ages 5-17; for young adults ages 18-21 participation of a parent, close friend or family member/caregiver is preferred but not required If patients have a caregiver, patients should agree to bring a caregiver to one of their hospital visits or have the caregiver schedule a separate study visit CAREGIVER PARTICIPANTS: Parents or adult primary caregiver (e.g., grandmother) of children ages 5 to 17 in treatment remission and has completed intensive therapy for ALL or AML Parent/Caregiver: parents or adult primary caregiver (e.g., grandmother) of children treated for ALL or AML ENTRY CRITERIA FOR CAREGIVERS: a caregiver can be anyone age 21 or over who is able to understand spoken English and understand the study process and provide informed consent; one caregiver for each patient will be eligible and must be chosen by the patient; for the purposes of this study, a caregiver is defined as a valued and trusted person in a patient’s life who is supportive in health care matters by providing valuable social support and/or direct assistive care; the caregiver accompanies the patient to medical appointments, is able to listen and give thoughtful advice and may be a family member, partner, friend, or professional caregiver INCLUSION CRITERIA FOR CAREGIVERS: selected by the patient when asked if there is a “family member, partner, friend or caregiver (age 21 or older) with whom you discuss or who can be helpful in health-related matters”; patients who cannot identify such a person (“caregiver”) can be eligible for the study; a caregiver need not be someone who lives with the patient or provides direct hands-on care; a caregiver can be any person who provides support (in any way) to the patient INCLUSION CRITERIA FOR CAREGIVERS: if a health care proxy signs consent for or with a patient, and wants to participate in the caregiver portion of the study, this same person will always be the caregiver selected; if a health care proxy does not want to enroll as a caregiver in the study or, if enrolled, chooses to stop their own participation in the caregiver portion of the study, but is able to assist the patient in completing the study, the patient can still participate; in other words, the health care proxy can choose NOT to participate in the caregiver portion of the study; this does not preclude the patient from participating in the patient portion of the study with the health care proxy’s assistance CAREGIVER: Primary nonprofessional, non-paid caregiver, as identified by the care recipient CAREGIVER EXCLUSION: Currently considers self to be a primary caregiver for anyone else other than children For patients aged 13-17 years, have one caregiver willing and able to participate in the study A relative or a friend who either lives with the patient or has in-person contact with him or her at least twice per week and is identified as the primary caregiver for transplant Identified by the patient as his/her primary caregiver who is providing daily assistance and/or emotional support Patients are eligible to enroll on this study with or without the enrollment of their caregiver CAREGIVER INCLUSION CRITERIA: Any caregiver is considered eligible for this study; the caregiver is the person identified by the patient as the one who provides the most regular physical and/or emotional support CAREGIVER EXCLUSION CRITERIA: There are no exclusion criteria to caregiver participation in this study FAMILY CAREGIVER: Chosen by a family member or friend with cancer to join them in participating in the MODEL Care study FAMILY CAREGIVER: Willing and able to travel to the class location for 6 weekly 2-hour sessions FAMILY CAREGIVER: Able and willing to consent CAREGIVER: Relative or friend who is identified by the patient participant who plans to regularly accompany the patient to the majority of their clinic visits CAREGIVER: Family caregiver must live with the patient or have in-person contact with him or her at least twice per week Patient and caregiver must be willing to be videotaped Subject has sufficient pleural fluid to allow safe insertion of an IPC. 7. Subject has negative pregnancy test if appropriate. 8. Subject or caregiver is able to perform home drainage of the pleural effusion (a caregiver can be a friend, family member or paid healthcare professional and applies to US sites only; UK subjects will have drainage managed by home-care nurses). Patient and caregiver: A history of a psychiatric illness unrelated to the HSCT within the past 18 months Patient and caregiver: Children under the age of 18 do not receive HSCTs in either program Patient has a family caregiver who lives with him/her or has visited him/her in-person at least twice a week for the past month Family caregiver identified by a lung cancer patient who meets the eligibility criteria listed above Caregiver lives with the patient or has visited the patient in-person at least twice a week for the past month Caregiver is willing to participate in this study Patient’s caregiver is ineligible for the study or declines study participation Caregiver does not have working phone service FAMILY CAREGIVER ELIGIBILITY REQUIREMENTS: Informal Caregivers will be accrued using the following inclusion criteria:\r\n* The primary informal caregiver as identified by patients participating in the study; this refers to either a family member or friend who will be providing the majority of care following surgery\r\n* Able to read and understand English Caregivers will be eligible for enrollment if they identify as the person who is the caregiver of a patient enrolled in a phase I oncology clinical trial Caregivers will be eligible for enrollment if they identify as the person who is the caregiver of a patient diagnosed with advanced cancer (stage IV, solid tumor) Family caregivers will need to be the primary family caregiver as identified by the lung cancer patient (ten caregivers from each of the following cancer care continuum points will be recruited) An effort will always be made to recruit patient and caregiver pairs, but unpaired patients are also eligible CAREGIVER: Have access to a mobile phone CAREGIVER: Unpaired caregivers, including former caregivers of patients who are now deceased, are eligible for the focus group only INFORMAL CAREGIVERS: The primary informal caregiver as identified by patients participating in the study; this refers to either a family member or friend who will be providing the majority of care following surgery CAREGIVERS ONLY: Must be primary caregiver of the patient Are the primary caregiver for the child participating in the study (defined as the individual who is responsible for daily implementation of health-related tasks for the child) A second parent/caregiver will be eligible to participate in the study if they are at least 18 years old and have at least on child under age 18 who is living in the same household and participating in the study Self-identifies as the child's main caregiver Participant and/or parent or caregiver must be able to read, understand, and complete the daily diary As this is intended to be a family-based intervention, all family members will be invited to participate, including those living in more than one household, however endpoints will only be assessed formally in the patient and identified primary caregiver; siblings are not required for participation CHILD: Has a caregiver, >= 18 years of age that is willing to participate in the study CAREGIVER/PARENT: Ability of caregiver to read and speak English CAREGIVER: Accompanying an MSK patient undergoing treatment for cancer by one of the consented HCPs as per the HCP and/or EMR Available caregiver