Patients who have received prior prostate or pelvic radiotherapy, including external beam or brachytherapy History of radiation therapy, either via external beam or brachytherapy within 28 days prior to registration Patients who have received prior prostate or pelvic radiotherapy, including external beam or brachytherapy No prior radiation therapy (external beam or brachytherapy) to the pelvis or prostate Patient has received any pelvic radiotherapy (including external beam and/or brachytherapy). Has received any pelvic radiotherapy (including external beam and/or brachytherapy.) Radiation therapy via external beam or brachytherapy within 28 days of registration Current or prior pelvic external beam radiotherapy within 5 years of entry Patient has received any pelvic radiotherapy (including external beam and/or brachytherapy.) Prior pelvic external beam radiotherapy (EBRT) Patients cannot have previously received pelvic external beam radiation or brachytherapy; patients may be enrolled while undergoing vaginal brachytherapy radiation treatment Patients who have received prior pelvic external beam radiation or brachytherapy will be excluded Prior pelvic external beam radiation therapy (RT). SUB-STUDY I: Prior pelvic external beam radiation therapy or brachytherapy SUB-STUDY II: Prior pelvic external beam radiation therapy or brachytherapy Prior pelvic external beam radiation therapy or brachytherapy Prior external beam, proton, or brachytherapy to the prostate