Participants may not have had any prior history of hypertensive crisis or hypertensive encephalopathy History of hypertensive crisis or hypertensive encephalopathy within 3 years Prior history of hypertensive crisis or hypertensive encephalopathy Patients with a history of hypertensive crisis or hypertensive encephalopathy within 6 months of study enrollment are not eligible Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis, hypertensive encephalopathy, reversible posterior leukoencephalopathy syndrome (RPLS). Has a known history of hypertensive crisis or hypertensive encephalopathy within 6 months prior to planned start of study drug History of hypertensive crisis or hypertensive encephalopathy within 3 years of the randomization (Bevacizumab-related exclusion) Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy History of hypertensive crisis or hypertensive encephalopathy within 3 years prior to registration Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy Patients are excluded if they have any prior history of hypertensive crisis or hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy. Prior history of hypertensive crisis or hypertensive encephalopathy Has prior history of uncontrolled hypertension, hypertensive crisis or hypertensive encephalopathy History of hypertensive crisis or hypertensive encephalopathy Participants may not have had any prior history of hypertensive crisis or hypertensive encephalopathy Has a history of hypertensive crisis or hypertensive encephalopathy Current uncontrolled hypertension as well as prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Inadequately controlled hypertension or prior history of hypertensive crisis or hypertensive encephalopathy. Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Blood pressure of > 150/100 mmHg, history of hypertensive crisis or hypertensive encephalopathy Any prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Have a history of hypertensive crisis or hypertensive encephalopathy or current poorly controlled hypertension despite standard medical management. Prior history of hypertensive crisis or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy Inadequately controlled hypertension or history of hypertensive crisis or encephalopathy. History of hypertensive crisis or hypertensive encephalopathy Blood pressure must be well-controlled (less than or equal to 140/90 mmHg at screening) with or without antihypertensive medication. Patients must have no history of hypertensive crisis or hypertensive encephalopathy; Patients with hypertensive crises or hypertensive encephalopathy Prior history of hypertensive crisis or hypertensive encephalopathy within the previous 3 months of first study treatment Prior history of hypertensive crisis or hypertensive encephalopathy