Participants must, in the opinion of the investigator, be capable of complying with the protocol The subject is capable of understanding and complying with the protocol and has signed the informed consent document The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with the protocol and has signed the informed consent document The subject is capable of understanding and complying with the protocol and has signed the informed consent document The subject is capable of understanding and complying with protocol requirements. The subject is capable of understanding and complying with the protocol and has signed the informed consent document Participants must in the opinion of the investigator be capable of complying with this protocol The participant is capable of understanding and complying with the protocol and has signed the informed consent document In the opinion of the Investigator, the patient is capable of understanding and complying with the protocol and has signed the informed consent document. Capable of understanding and complying with protocol requirements. Participants must, in the opinion of the Investigator, be capable of complying with the requirements of this protocol including self-administration of study treatment Capable of understanding and complying with the protocol requirements and has signed the informed consent document. The participant is capable of understanding and complying with the protocol and has signed the informed consent document Must be willing and capable of understanding and cooperating with the requirements of the study. The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Capable of understanding and complying with the protocol and has signed the informed consent document The patient is capable of understanding and complying with the protocol and has signed the informed consent document. A signed informed consent form must be obtained before any study-specific procedures are performed. mCRPC EXPANSION COHORT: Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent Subject is capable of understanding the informed consent process Capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Capable of understanding the informed consent and complying with the protocol and signed the informed consent document prior to any study-specific screening procedures or evaluations being performed The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Capable of understanding and complying with the protocol requirements and has signed the informed consent document Participant must be capable of understanding and complying with the protocol and willing to sign a written informed consent document Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent Capable of understanding and complying with the protocol requirements and has signed the informed consent document Capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with parameters as outlined in the protocol Patient must be capable of understanding and complying with protocol requirements and is willing to give informed consent The participant is capable of understanding and complying with the protocol requirements and has signed the informed consent document The subject is capable of understanding and complying with parameters as outlined in the protocol In the opinion of the investigator, the participant or legal guardian is capable of understanding and complying with protocol requirements for the duration of the study. Participants must, in the opinion of the investigator, be capable of complying with the protocol Must in the opinion of the investigator be capable of complying with this protocol The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Participants must, in the opinion of the investigator, be capable of complying with the protocol Written voluntary informed consent: the patient is capable of complying with the requirements of the written Informed Consent Form and complying with protocol requirements The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Subjects must in the opinion of the Investigator be capable of complying with this protocol Participants must be capable of understanding and complying with the protocol requirements and signing informed consent Participants must, in the opinion of the investigator, be capable of complying with the requirements of this protocol Capable of complying with study procedures and communicating with study personnel Patient is capable of complying with study procedures Patient is capable of complying with study procedures Patient is capable of complying with study procedures The subject is capable of understanding and complying with the protocol requirements and has signed the informed consent document Patient is capable of complying with study procedures Capable of understanding and complying with protocol requirements. The patient is capable of understanding and complying with the protocol and has signed the informed consent document.