Must not be breastfeeding/lactating. Breastfeeding should be discontinued Lactating or breastfeeding women are excluded, breastfeeding should be discontinued prior to being treated with AZD1775; these potential risks may also apply to other agents used in this study Breastfeeding Pregnancy or breastfeeding (pregnant or breastfeeding women are excluded from this study; breastfeeding should be discontinued if the mother is treated with oral THU-Dec Women who are breastfeeding and who are unwilling to stop breastfeeding prior to study entry Inability or refusal to practice effective contraception during therapy or the presence of pregnancy or active breastfeeding; pregnant or breastfeeding women will be excluded from participation in this trial Female patients who are breastfeeding; breastfeeding should be discontinued if the mother is treated with Pexa-Vec Female patients who are pregnant or breastfeeding; breastfeeding should be discontinued Not breastfeeding Breastfeeding patients are ineligible Women must not be pregnant or breastfeeding; breastfeeding must be discontinued or the subject is not eligible for the study PHASE II: Women must not be pregnant or breastfeeding; breastfeeding must be discontinued or the subject is not eligible for the study Breastfeeding should be discontinued Breastfeeding Breastfeeding Pregnant or breastfeeding; breastfeeding may not resume for 14 days after the last dose of pazopanib Not breastfeeding Pregnancy or breastfeeding (pregnant or breastfeeding women are excluded from this study; breastfeeding should be discontinued if the mother is treated with oral tetrahydrouridine- decitabine [THU-Dec]) Participants who are breastfeeding are excluded They are not breastfeeding; Currently breastfeeding. Pregnant and breastfeeding women are excluded from this study; breastfeeding should be discontinued if the mother is treated with denosumab; there is no minimum amount of time since pregnancy/breastfeeding required before enrolling into the study; however, the date of delivery, pregnancy termination, or weaning from breastfeeding will be documented on case report forms; female subjects of child bearing potential and not willing to use, in combination with her partner, highly effective contraception during treatment will be excluded Current breastfeeding Breastfeeding No breastfeeding Breastfeeding Participants who are breastfeeding are excluded Breastfeeding