Patient’s baseline imaging must not indicate the presence of tumor invading or encasing any major blood vessels Any aneurysm of the major vessels. The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The participant has tumor invading or encasing any major blood vessels The participant has tumor in contact with, invading, or encasing major blood vessels or radiographic evidence of significant cavitary pulmonary lesions The subject has tumor invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels Central lung lesions involving major blood vessels (arteries or veins) or a tumor encasing major blood vessels (i.e. carotid artery) Patient has a tumor amenable to injection of Toca 511 (ie, ? 2 cm and not close to or invading major vessels). The subject has tumor in contact with, invading or encasing any major blood vessels Tumor invading or encasing any major blood vessels The subject has tumor abutting, invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels The subject has tumor in contact with, invading or encasing any major blood vessels No tumor in contact with, invading or encasing any major blood vessels Tumor in contact with, invading or encasing any major blood vessels found on radiology report The subject has tumor invading (or concern for invasion) major blood vessels The subject has tumor invading (or there is concern for invasion of) major blood vessel The participant has radiographic evidence of cavitating pulmonary lesion(s) or tumor in contact with, invading or encasing major blood vessels The subject has a pulmonary lesion abutting or encasing a major blood vessel Tumor invading a major blood vessel (such as the carotid artery) The subject has tumor in contact with, invading or encasing major blood vessels The subject has tumor invading any major blood vessels Evidence of tumor invading major blood vessels, cavitation of one or more pulmonary tumor mass(es) ortracheo-esophageal fistula The subject has tumor in contact with, invading, or encasing major blood vessels The subject has tumor invading or encasing any major blood vessels The subject has tumor invading major blood vessels