Calculated serum creatinine clearance >= 60 mL/min/1.73 m^2, within 28 days prior to administration of study treatment Adequate renal function determined within 6 weeks prior to randomization defined as the most recent serum creatinine =< ULN or measured or calculated creatinine clearance > 60 mL/min STEP I: Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior to randomization) Serum creatinine =< 1.5 times ULN OR calculated creatinine clearance >= 70 mL/min Calculated creatinine clearance > 30 ml/min within 14 days prior to step 2 randomization Serum creatinine must be =< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) must be > 30 mL/min; must be obtained within 28 days prior to registration Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min, obtained within 28 days prior to step 2 registration Within 14 days of registration: Calculated (calc.) creatinine clearance > 50 mL/min Patients must have adequate renal function as documented by a calculated creatinine clearance >= 60 mL/min, within 28 days prior to registration Obtained within 28 days prior randomization: serum creatinine =< 1.5 x ULN for the lab or measured or calculated creatinine clearance >= 30 mL/min Serum creatinine =< 1.5 ULN OR measured or calculated creatinine clearance >= 30 mL/min Or a calculated or measured creatinine clearance or radioisotope GFR >= 70ml/min/1.73m^2 obtained within 14 days prior to registration Calculated creatinine clearance (Cr Cl) >= 50 ml/min; eligible for full dose methotrexate Calculated creatinine clearance at least 30 mL/min. Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance > 60 ml/min. Calculated creatinine clearance > 50 mL/min PHASE II INCLUSION CRITERIA: Calculated creatinine clearance > 50 mL/min Normal creatinine for age or a calculated creatinine clearance >= 60 mL/min/1.73 m^2 Estimated creatinine clearance >= 60 mL/min as calculated using the method standard for the institution Calculated creatinine clearance >= 50 mL/min Obtained =< 21 days prior to registration and confirmed prior to the first dose of study drug: Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >50 mL/min; Calculated or measured creatinine clearance >= 30 ml/min, obtained =< 14 days prior to registration Calculated creatinine clearance >= 60 ml/min. Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min Renal: Creatinine clearance of ? 40 mL/min, estimated or calculated. Calculated creatinine clearance of >= 50 mL/min Within 4 weeks before enrollment: Calculated creatinine clearance > 40 mL/min Calculated creatinine clearance >= 10 mL/min Creatinine =< 1.5 ULN or calculated creatinine clearance >= 50 ml/min Obtained =< 28 days prior to registration: Creatinine =< 1.0 x ULN OR measured or calculated creatinine clearance (per institutional standard) must be >= 60 ml/min Serum creatinine clearance of >= 50 ml/min (calculated or measured) Creatinine > or = 2.0 x ULN or creatinine clearance < 50 mL/min (calculated). Obtained within 14 days prior to enrollment: calculated creatinine clearance > 30 ml/min Patients must have a calculated creatinine clearance of >= 35 Calculated or measured creatinine clearance >= 50 ml/min Obtained =< 14 days prior to registration: Calculated or measured creatinine clearance >= 30 ml/min Calculated creatinine clearance >= 30 mL/min/1.73 m^2 Creatinine clearance >= 40 mL/min (measured or calculated per local practice) Calculated or measured creatinine clearance (method determined by the prescribing physicians) < 50 ml/min Creatinine clearance >= 40 mL/min, estimated or calculated Calculated creatinine clearance >= 50 mL/min Serum creatinine =< 1.5 x the ULN and calculated creatinine clearance > 30 ml/min Calculated creatinine clearance >= 45 mL/min Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >= 50 mL/min/1.73 m^2 Calculated creatinine clearance >= 30 mL/min Either a serum creatinine ? ULN for age, or calculated or measured GFR ? 70 mL/min/1.73 m2 Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance ? 30 mL/min Calculated creatinine clearance >= 30 mL/min Serum creatinine =< 1.5 x ULN OR a measured creatinine clearance or calculated creatinine clearance >= 50 mL/min Creatinine clearance > 50 ml/min (calculated creatinine clearance is permitted) Calculated creatinine clearance > 30 ml/min Calculated creatinine clearance >= 45 mL/min/1.73 m^2 Serum creatinine =< 1.5 x ULN or clearance >= 60 mL/min (measured or calculated) Calculated creatinine clearance > 60 ml/min Calculated creatinine clearance ?50 mL/min. Calculated creatinine clearance of ? 50 ml/min. Calculated Creatinine Clearance of 50 ml/min Calculated creatinine clearance > 50 mL/min. Calculated creatinine clearance >30ml/m Calculated creatinine clearance of <60 mL/min in Stage 1 and <40 mL/min in Stage 2 Patients with moderate or severe renal impairment (calculated creatinine clearance of < 60 mL/min) ORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Calculated creatinine clearance > 50 mL/min Creatinine clearance > 40 ml/min (calculated or measured) Calculated creatinine clearance >= 30 mL/min Estimated creatinine clearance >= 60 ml/min as calculated using the method standard for the institution Calculated creatinine clearance of > 60 mL/min/m^2, within 28 days prior to registration. Creatinine clearance (calculated or measured) > 30 mL/min Calculated creatinine clearance >= 50 mL/min Calculated (calc.) creatinine clearance > 45 mL/min Serum creatinine =< ULN for the lab and measured or calculated creatinine clearance > 60 mL/min within 28 days before randomization Calculated creatinine clearance > 70 mL/min/1.73 m^2 Calculated creatinine clearance >= 50 cc/min Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min Patients must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min Measured or calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >= 30 mL/min within 14 days of enrollment Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min Calculated or measured creatinine clearance >= 30 ml/min within 14 days prior to registration Creatinine clearance (calculated or 24 hour) >= 30 ml/min Calculated creatinine clearance >= 60 mL/min Obtained within 28 days prior to registration: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 60 mL/min Calculated creatinine clearance ?60 mL/min/1.73m^2 Calculated creatinine clearance >= 30 mL/min within four weeks prior to randomization Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min be obtained within 42 days prior to registration CLINICAL/LABORATORY CRITERIA: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 40 mL/min; this result must have been obtained within 28 days prior to registration Calculated creatinine clearance ? 30 mL/min Calculated Creatinine clearance>/= 45ml/min Calculated creatinine clearance >= 45 ml/min Measured or calculated creatinine clearance >= 40 ml/min AMKL PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/min MF PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/min Calculated creatinine clearance > 60 mL/min Calculated or measured creatinine clearance ? 40 mL/min An average calculated creatinine clearance > 30 mL/min/1.73 m^2 Calculated creatinine clearance > 30 ml/min Calculated creatinine clearance > 50 mL/min Calculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 2 Randomization Calculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 3 registration Calculated creatinine clearance >= 30 mL/min Creatinine clearance of >= 40 mL/min, estimated or calculated Serum creatinine ? 1.5 × ULN or calculated or measured creatinine clearance ? 50 mL/min/1.73 m2 Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 ml/min Serum creatinine =< 1.5 x IULN or a calculated or measured creatinine clearance >= 50 mL/min; these tests (including creatinine [mg/dl] if using calculated creatinine clearance) must be obtained within 14 days prior to registration Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >= 30 mL/min Serum creatinine =< 1.5 x ULN, or calculated creatinine clearance >= 60 ml/min Calculated creatinine clearance >= 60 mL/min Calculated creatinine clearance >= 45 mL/min Calculated creatinine clearance > 30 ml/min Calculated creatinine clearance of ? 45 mL/min Serum creatinine =< 1.5 x the ULN or calculated creatinine clearance >= 60 ml/min Calculated creatinine clearance ? 60 mL/min. Calculated creatinine clearance > 30 ml/min Children (< 18 years old): calculated creatinine clearance must be > 60 mL/min Calculated creatinine (calc. creat.) clearance >= 60 ml/min Creatinine =< 1.5 x institutional ULN or creatinine clearance (calculated or measured) > 60 ml/min Creatinine clearance (calculated creatinine clearance is permitted) should be > 40 ml/min Creatinine clearance >= 50 ml/mm (can be calculated) Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min Creatinine < 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min Creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 60 ml/min Calculated creatinine clearance > 30 mL/min/1.73 m^2 Calculated creatinine clearance >= 45 ml/min Creatinine < ULN OR calculated creatinine clearance >= 50 mL/min\r\n* Creatinine clearance should be calculated by Cockcroft and Gault method Subjects must have calculated creatinine clearance >= 30 ml/min Creatinine of measured or calculated creatinine clearance of >= 50 cc/min Calculated creatinine clearance >= 30 mL/min Renal: Serum creatinine < 1.5 x ULN OR calculated creatinine clearance (CLcr) ? 60 ml/min Renal: Serum creatinine < ULN OR calculated creatinine clearance (CLcr) of ? 60 ml/min Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance >= 30 mL/min Serum creatinine =< 1.5 x ULN or calculated creatinine clearance > 50 mL/min Urothelial cancer patients should be ineligible for cisplatin based on one or more of the following:\r\n* Calculated creatinine clearance of < 60 mL/min (but >= 30 mL/min)\r\n* Solitary kidney\r\n* Karnofsky performance status < 80% Calculated creatinine clearance of ? 60 ml/min. Creatinine clearance equal or > 50 ml/min (calculated) Creatinine clearance < 50 ml/min (calculated) Calculated or measured creatinine clearance >= 45 mL/min Creatinine >= 1.5 × ULN for the institution (or a calculated creatinine clearance < 60 mL/min/1.73 m2) Serum creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min Serum creatinine > 1.5× ULN (or a calculated creatinine clearance < 60 mL/min/1.73 m2) Calculated creatinine clearance >= 60 mL/min Calculated creatinine clearance > 30 ml/min (unless demonstrated Hodgkin lymphoma involvement of the kidney) Calculated creatinine clearance >= 30 mL/min Calculated creatinine clearance > 50 mL/min. Calculated creatinine clearance > 50 mL/min. Calculated creatinine clearance > 20 mL/min per institutional standard Calculated or measured creatinine clearance >= 60 mL/min Calculated creatinine clearance >= 30 mL/min\r\n* For females, use 85% of calculated creatinine clearance (CrCl) value Renal insufficiency (defined as calculated creatinine clearance < 30 mL/min) Severe renal impairment (calculated creatinine clearance =< 29 cc/min) Patients must have a calculated creatinine clearance > 30 mL/min; the serum creatinine value used in the calculation must have been obtained within 28 days prior to registration Calculated or measured creatinine clearance >= 30 mL/min Creatinine clearance (24 hour or calculated) > 50 ml/min Renal disease, and we will use a calculated serum creatinine clearance over 30 ml/min at the screening appointment as an exclusion criteria Creatinine clearance calculated >= 50 mL/min Creatinine clearance < 50 ml/min (calculated or measured) Creatinine clearance < 50 mL/min (calculated or measured) Calculated creatinine clearance ? 50 mL/min Calculated creatinine clearance >= 30 mL/min Have a calculated creatinine clearance >= 50 mL/min NORMAL VOLUNTEERS: Have a calculated creatinine clearance >= 50 ml/min Calculated creatinine clearance >= 30 mL/min calculated creatinine clearance > 100 mL/min/1.73 m2 Adequate renal function (calculated creatinine clearance ? 30 mL/min) Calculated creatinine clearance >= 60 mL/min