Must have a life expectancy of at least 10 years based on age and comorbidities but excluding diagnosis of breast cancer. Histologically or cytologically proven diagnosis of breast cancer with evidence of metastasis. Histological diagnosis of breast cancer Pathologically proven diagnosis of breast cancer Current diagnosis of bilateral breast cancer History of radiotherapy for current breast cancer diagnosis Diagnosis of breast malignancy Stage at diagnosis T2 through T4a-c, N0 through N2, and M0; patients with inflammatory breast cancer or metastatic disease at diagnosis will be excluded; patients with multicentric, multifocal, and/or bilateral disease are allowed to participate so long as all tumors meet the histologic criteria of the study Subjects with confirmed diagnosis of recurrent or metastatic breast cancer based on histopathology examination Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer) diagnosis of HR+, HER2+ breast cancer (BC) Confirmed diagnosis of HR+/HER2- breast cancer Have a diagnosis of HR+, HER2- breast cancer. Have a diagnosis of HR+, HER2- breast cancer Pathologically confirmed diagnosis of breast cancer with documented progressive disease Current diagnosis of bilateral breast cancer Current diagnosis of any other active or clinically significant non-breast cancer Pathologically confirmed diagnosis of breast cancer (central confirmation is not required) Have a diagnosis of breast cancer and be chemotherapy naive; NOTE: prior methotrexate for non-cancerous conditions is allowed Post-menopausal patients at breast cancer (BC) diagnosis, as determined locally Diagnosis of other active malignancy; prior treated malignancies in addition to breast cancer are acceptable PATIENT: Confirmed medical diagnosis of breast or thoracic cancer regardless of stage and followed at DCC for management New breast cancer diagnosis Stage IV breast cancer diagnosis (metastases remote from the breast) Recent diagnosis of breast cancer with pending surgery as primary treatment for breast cancer Confirmed first diagnosis of stage IV breast cancer or a recurrent diagnosis of metastatic breast cancer (MBC) (i.e., spread to distant organs), any time since diagnosis Patient must be an Asian American who has had a breast cancer diagnosis in the past 5 years Primary diagnosis of breast cancer (initial or recurrence) within the last two years Have a diagnosis of stage I-III female breast cancer or colorectal cancer within the past 5 years; bilateral or multiple primary breast cancers are permitted; individuals who have had more than one type of cancer (e.g., both breast and melanoma) are permitted as long as the breast (or colorectal) diagnosis meets the other criteria and primary treatment for any cancer is not ongoing YOUNG BREAST CANCER SURVIVORS (YBCS): Breast cancer (Stages 0-III) diagnosis YBCS: Breast cancer diagnosis age ? 45 years Patients who have a diagnosis of breast cancer Patients with a recurrent breast cancer diagnosis A diagnosis of local regional breast cancer (stage 0-IIIa) Had a previous diagnosis of breast cancer (any type or stage) as confirmed by official medical records Have a diagnosis of prostate, breast, lung, lymphoma, or gynecological cancer Have a previous diagnosis of breast cancer New diagnosis of breast cancer stage 1-2 Histologically confirmed stage I, II or III breast cancer (if the patient has had more than one breast cancer diagnosis, then the most recent diagnosis) Primary diagnosis of breast cancer within the last three years PHASE I: Has a first, primary diagnosis of unilateral stage 0, 1, 2, or 3a breast cancer (patients with bilateral breast cancer will be excluded from participation) Diagnosis of stage IV breast cancer or recurrent metastatic breast cancer Diagnosis of metastatic breast cancer Diagnosis of recurrent breast cancer Diagnosis of breast cancer with adjuvant chemotherapy treatment Stage 1A – 2B breast cancer diagnosis Diagnosis of breast cancer Diagnosis of HER2-positive breast cancer History of a diagnosis of breast cancer Breast cancer diagnosis within past 5 years Have a confirmed diagnosis of breast cancer; participants can have had more than one primary cancer diagnosis in the past Have a diagnosis of breast cancer, any stage. Women initially diagnosed with breast cancer by histological tissue diagnosis in 2003 or later Prior breast cancer or DCIS diagnosis Patients with known diagnosis of breast cancer Have a prior diagnosis of T1 or T2 breast cancer diagnosed within the last 10 years History of prior breast cancer treated within the past two years; patients completing all breast cancer-specific treatment over two years prior to the current diagnosis are eligible COHORT B: No prior diagnosis of breast cancer but at high risk for development of breast cancer and participating in HSC 4601 Diagnosis of breast cancer Pathologically confirmed diagnosis of HER2 positive breast cancer of any stage (previous treatment is allowed without limits on lines of prior therapy) Previous history or current diagnosis of breast cancer Patients with a previous diagnosis of invasive breast cancer who are less than 3 years from diagnosis Life expectancy of at least 5 years, excluding diagnosis of breast cancer (comorbid conditions should be taken into consideration, but breast cancer diagnosis is not a consideration) Diagnosis of stage I-IIIA breast cancer within past 5 years (confirmed by medical record review) New diagnosis of breast cancer The patient must have a histologically proven diagnosis of stage I through IIIC breast cancer Pathologic diagnosis of invasive breast cancer or high suspicion of breast cancer based on imaging with a suspicious lesion found in the breast and recommended for biopsy or have a confirmed diagnosis of cancer; Women who have undergone open surgical (excisional) biopsy for breast cancer diagnosis Patients must have a current diagnosis of sarcoma, lymphoma, or HER2(-) breast cancer Patients with a prior breast cancer diagnosis Pregnant at the time of diagnosis of their breast cancer. Diagnosis of primary breast cancer.