Patients with a history of any malignancy are ineligible Prior malignancy other than acute leukemia is allowed, provided it is in remission and there is no plan to treat the malignancy at the time of registration Prior malignancy History of prior malignancy, except (Criteria a through f): History of another malignancy except for: T-cell malignancy Have a history of another primary malignancy, with the exception of: MALIGNANCY CRITERIA: History of malignancy other than their lymphoma with the exception of: Immunosuppression, not related to prior treatment for malignancy. Has a history of another malignancy. Has a malignancy: Presence of malignancy. Resistant malignancy History of a non-lymphoid malignancy except for protocol allowed exceptions Any malignancy Patients with any other prior malignancy are not allowed except for the following: History of malignancy; History of another primary malignancy History of concurrent malignancy requiring active therapy or prior history of another malignancy within 5 years. Prior chemotherapy for any malignancy History of prior malignancy History of prior malignancy, with the exception of the following: Patients who have a history of any hematopoietic malignancy History of prior malignancy except: Prior malignancy except for any of the following: Prior treatment for lymphoid malignancy: Prior malignancy. History of any other malignancy History of another primary malignancy Patients with a history of any other malignancy will not be eligible another primary malignancy History of prior malignancy for which patient is receiving other specific treatment for their cancer Another primary malignancy History of other malignancy (not including the underlying malignancy that was the indication for transplant) History of other primary malignancy (including myeloid malignancy, e.g., myelodysplastic syndrome), unless Prior history of metastatic malignancy Actively being treated for other malignancy; if there is a history of prior malignancy, patient must not be receiving other specific treatment for their cancer Have borderline malignancy Patients must have pathologically-confirmed malignancy Time since last therapy for treatment of underlying malignancy: E 08. Prior malignancy. Any history of another metastatic malignancy Subjects with a history of recent (within 28 days) systemic therapy for their underlying malignancy Prior history of other malignancy except: Confirmed malignancy. Prior treatment of any kind for this malignancy History of another malignancy, some exceptions may apply. No history of any hematopoietic malignancy Malignancy OTHER than the BRAF mutant malignancy under study. History of any hematopoietic malignancy Patients may have a history of other prior malignancy Metastatic malignancy of any kind Metastatic malignancy of any kind Have a diagnosed malignancy Concurrent malignancy or metastatic malignancy of any kind Metastatic malignancy of any kind Other current malignancy or metastatic malignancy of any kind Concurrent malignancy or metastatic malignancy of any kind Women with a history of a prior malignancy Have a second primary malignancy or any history in any time frame of a prior malignancy. Patients may have had a prior malignancy Other malignancy with life expectancy < 1 year due to the other malignancy