Patient has hypersensitivity to boron, mannitol sucrose, histidine (as base and hydrochloride salt) and polysorbate 80 or any of the components of study therapy including required prophylactic medications Patients with hypersensitivity to bortezomib, boron or mannitol. Known hypersensitivity to Velcade, boron, or mannitol Known or suspected hypersensitivity to 5-azacitidine or mannitol Known or suspected hypersensitivity to azacitidine or mannitol Known hypersensitivity to azacitidine or mannitol Have a history of allergic (anaphylactic) sensitivity to bortezomib, boron or mannitol History of allergy to mannitol History of hypersensitivity to mannitol Subjects must not have a known history of hypersensitivity to mannitol Must not have a known or suspected hypersensitivity to azacitidine, mannitol, or compounds of similar composition to azacitidine Patient with hypersensitivity to bortezomib, boron or dexamethasone Patient has hypersensitivity to bortezomib, boron, or mannitol Known hypersensitivity to any of the following: bortezomib, boron, mannitol Known allergy or hypersensitivity to azacitidine, mannitol, or midostaurin Previous history of hypersensitivity to bortezomib, boron, or mannitol; known hypersensitivity to the components of study drug or its analogs Patient has hypersensitivity to VELCADE (bortezomib), boron, or mannitol Participant who has hypersensitivity to bortezomib, boron, or mannitol Known intolerance/hypersensitivity to IMiDs, dexamethasone, boron or mannitol, sucrose, histidine or polysorbate 80. Known or suspected hypersensitivity to azacitidine or mannitol Known or suspected hypersensitivity to azacitidine, mannitol, or durvalumab, its constituents, or to any other humanized monoclonal antibody. Patient has hypersensitivity to bortezomib, boron or mannitol Known hypersensitivity to mannitol. Has a known hypersensitivity to azacitidine or mannitol Patients with known allergy to sorafenib or azacitidine, mannitol or any of their components Patients must not have a known allergy to mannitol Patient has hypersensitivity to VELCADE (bortezomib), boron, or mannitol Patients must not have hypersensitivity to bortezomib, boron or mannitol Participant has a known or suspected hypersensitivity to azacitidine, mannitol, or any other ingredient used in the manufacture of CC-486 (see the Azacitidine IB). History of allergic reaction/hypersensitivity attributed to compounds containing boron, mannitol, polysorbate 80 or sodium citrate dehydrate Patient has hypersensitivity to bortezomib, boron, or mannitol Poor tolerability or known allergy to any of the study drugs or compounds of similar chemical or biologic composition to dexamethasone, boron or mannitol Known or suspected hypersensitivity to azacitidine or mannitol Known hypersensitivity to bortezomib, boron, or mannitol History of allergy to mannitol Known allergy to bortezomib, boron, or mannitol Known hypersensitivity to bortezomib, boron, or any of the other agents utilized in this protocol Patient has hypersensitivity to bortezomib, boron, or mannitol Known or suspected hypersensitivity to 5-azacitidine, romidepsin, mannitol or other agents used in this study Hypersensitivity to boron or mannitol, or compounds containing these components Patient has hypersensitivity to bortezomib, boron or mannitol History of allergic reactions to compounds containing boron, mannitol, VELCADE Known hypersensitivity to any components of pracinostat, azacitidine, or mannitol History of sensitivity to mannitol Hypersensitivity to bortezomib, boron, or mannitol Known or suspected hypersensitivity to azacitidine or mannitol No history of hypersensitivity to bortezomib, boron or mannitol Patient has hypersensitivity to bortezomib, boron, or mannitol Known hypersensitivity to mannitol Known hypersensitivity to bendamustine or mannitol Patient has hypersensitivity to bortezomib, boron, or mannitol Known hypersensitivity to azacitidine or mannitol Known or suspected hypersensitivity to azacitidine or mannitol Hypersensitivity to VELCADE, boron, mannitol, or any other component of protocol therapy Known hypersensitivity to bortezomib, boron, or mannitol Known or suspected hypersensitivity to 5'-azacitidine or mannitol Allergy to mannitol Patients with hypersensitivity to carfilzomib, Velcade, boron, or mannitol. Patient has hypersensitivity to bortezomib, boron or mannitol Patient has a history of allergic reaction attributable to bortezomib or other compounds containing boron or mannitol (Phase 1b and 2a only) Known or suspected hypersensitivity to ofatumumab, bendamustine or mannitol. Known hypersensitivity to bendamustine, mannitol, or other study-related drugs Hypersensitivity to azacitidine or mannitol Known or suspected hypersensitivity to azacitidine or mannitol History of sensitivity to mannitol Known or suspected hypersensitivity to azacitidine, mannitol, its constituents, or to any other humanized monoclonal antibody Patients with hypersensitivity to bortezomib, boron or mannitol Patients with hypersensitivity to bortezomib, boron or mannitol Known or suspected hypersensitivity to azacitidine, pembrolizumab or the excipients of any of the study drugs (including mannitol). Known or suspected hypersensitivity to monoclonal antibodies.