Patients with a history of stroke or intracranial hemorrhage within 6 months prior to registration are not eligible History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment No active intracranial metastases History of stroke/intracranial hemorrhage =< 6 months prior to registration History of stroke or intracranial hemorrhage within 6 months prior to randomization History of stroke or intracranial hemorrhage within 6 months of first dose Intracranial hemorrhage grade > 1 not attributable to recent neurosurgery History of stroke or intracranial hemorrhage within 6 months prior to enrollment Any history of symptomatic intracranial hemorrhage. Patients should not have a stroke or intracranial hemorrhage within last 6 months Patients will not be eligible if they have a history of intracranial hemorrhage in past 6 months History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of ischemic stroke or intracranial hemorrhage =< 180 days prior to pre-registration History of stroke/intracranial hemorrhage =< 6 months prior to registration History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months of the first dose of study drug History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months before the first dose of study drug History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment Evidence of acute intracranial / intra-tumoral hemorrhage, except for participants with stable grade 1 hemorrhage. History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to randomization Intracranial hemorrhage except for tumor associated micro hemorrhage. History of stroke or intracranial hemorrhage within 6 months prior to study entry History of intracranial hemorrhage (either by clinical history or neuroimaging) History of stroke or intracranial hemorrhage within 6 months of screening No history of intracranial hemorrhage Relapsed/refractory MCL: History of stroke or intracranial hemorrhage within 6 months prior to signing the consent Newly diagnosed MCL: History of stroke or intracranial hemorrhage within 6 months prior to signing the consent Evidence of recent (less than 2 weeks) intracranial hemorrhage. Have evidence of significant (ie, symptomatic) intracranial hemorrhage. History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrolment History of stroke or intracranial hemorrhage within 3 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to signing the consent. History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months before randomization. History of stroke or intracranial hemorrhage within 6 months before randomization. history of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or clinically significant intracranial hemorrhage within 6 months before first dose of study drug. History of stroke or intracranial hemorrhage within 6 months prior to enrollment No stroke or intracranial hemorrhage within the last 6 months History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment. History of stroke or intracranial hemorrhage within 6 months prior to enrollment Patient has history of stroke or intracranial hemorrhage =< 6 months from starting study drugs History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to the first dose of study drug History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to study entry Active intracranial hemorrhage History of stroke or intracranial hemorrhage within 6 months prior to the first dose of ibrutinib History of stroke or intracranial hemorrhage within 6 months prior to enrollment. History of stroke or intracranial hemorrhage within 12 months prior to enrollment. Subjects with a history of stroke or intracranial hemorrhage within 6 months prior to enrollment are not eligible History of stroke or intracranial hemorrhage within 6 months prior to randomization History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to random assignment History of Grade 2 (CTCAE v4) or greater acute intracranial hemorrhage. History of stroke or intracranial hemorrhage within 6 months prior to randomization; or clinically significant cardiovascular disease History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months of screening would be exclusion for ibrutinib therapy but idelalisib would be an option History of stroke or intracranial hemorrhage within 6 months prior to registration History of stroke or intracranial hemorrhage within 6 months prior to enrollment Patients with a history of known stroke or intracranial hemorrhage within 6 months prior to study treatment are excluded History of stroke or intracranial hemorrhage within 6 months prior to enrollment. History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment Patients with a history of intracranial hemorrhage are not eligible. History of stroke or intracranial hemorrhage =< 6 months prior to registration History of stroke or intracranial hemorrhage within 6 months prior to treatment Evidence of significant intracranial hemorrhage History of stroke or intracranial hemorrhage within 6 months of enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment History of stroke or intracranial hemorrhage within 6 months prior to enrollment Diagnosis of intracranial hemorrhage within the past 3 months, including intratumoral hemorrhage into brain metastases from a systemic cancer Any history of significant hemorrhage (requiring hospitalization or transfusion) within the last 6 months (excluding hemorrhage during operative procedure) EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): History of stroke or intracranial hemorrhage within 6 months prior to screening Patients must not have evidence of significant intracranial hemorrhage History of stroke or intracranial hemorrhage within 6 months prior to enrollment No hemorrhage after treatment. History of stroke or intracranial hemorrhage within 6 months of first dose