Subject has had major surgery within 6 weeks prior to Cycle 1 Day-2 (subjects must have completely recovered from any previous surgery prior Cycle 1 Day-2). Major surgery within 28 days before Cycle 1 Day 1 Major surgery within 14 days prior cycle 1, day 1 Has had major surgery within 21 days before cycle 1, day 1 Has had major surgery within 21 days before cycle 1, day 1. Major surgery within 4 weeks prior to cycle 1, other than for diagnosis. Recent major surgery (within 6 weeks prior to the start of cycle 1, day 1) other than for diagnosis Major surgery or radiotherapy within 21 days prior to Day 1 of Cycle 1 or anticipation of needing such procedure while receiving study treatment A minimum of 4 weeks from any major surgery prior to cycle 1 day 1 History of recent major surgery within 6 weeks prior to the start of cycle 1, day 1 other than for diagnosis Patients who have had major surgery within 21 days before cycle 1, day 1 Has had major surgery within 21 days before cycle 1, day 1 Major surgery within four weeks before cycle 1 day 1 Planned major surgery during the study or within 4 weeks of Cycle 1, Day 1 Subject has received prior therapy for cancer or major surgery within 28 days, or 42 days for nitrosourea or mitomycin C, prior to Cycle 1 Day 1, or 14 days for tamoxifen; Recent major surgery within 4 weeks prior to Cycle 1, Day 1, other than superficial lymph node biopsies for diagnosis Has had major surgery within 21 days before cycle 1 day 1 Major surgery within 28 days before Cycle 1 Day 1 Patients with recent major surgery within 14 days prior to cycle 1, day 1 Major surgery within three weeks before cycle 1 day 1 Received monoclonal antibodies or had major surgery within 30 days of the first dose of brigatinib (Day 1, Cycle 1). Major surgery or radiation therapy within 4 weeks of cycle 1, day 1 No major surgery within 14 days and minor surgery within 7 days prior to cycle 1 day 1 Major surgery within 14 days and minor surgery within 7 days prior to cycle 1 day 1 Major surgery within 4 weeks from cycle # 1 Major surgery within 2 weeks before cycle 1 day 1 Major surgery within 28 days before Cycle 1 Day 1 Recent major surgery (within 6 weeks before the start of Cycle 1 Day 1), other than for diagnosis Major surgery within 4 weeks, or minor surgery within 2 weeks prior to day 1 of cycle 1 Major surgery within four weeks before cycle 1, day 1 Patient received radiation therapy or major surgery within one month of Cycle 1 Day 1 Major surgery within 28 days before Cycle 1 Day 1