Has active hemolytic anemia, plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome, amyloidosis, significant autoimmune, CNS or other malignant disease POEMS syndrome POEMS syndrome or active plasma cell leukemia; POEMS syndrome requiring therapy, previously treated or untreated POEMS syndrome Diagnosed with plasma cell leukemia, POEMS syndrome or amyloidosis. Plasma cell leukemia, primary amyloidosis or POEMS syndrome POEMS syndrome, Plasma cell leukemia, Waldenstrom's macroglobulinemia or Amyloidosis Plasma cell leukemia, primary amyloidosis or POEMS syndrome POEMS syndrome Diagnosis of Waldenstrom's macroglobulinemia, POEMS syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome Diagnosis of smoldering multiple myeloma, Waldenstrom's macroglobulinemia, POEMS syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome Has known gastrointestinal condition or procedure that could interfere with swallowing or the oral absorption of tolerance of IXAZOMIB - Diagnosis of smoldering multiple myeloma, Waldenstrom's macroglobulinemia, POEMS syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome Multiple myeloma of IgM subtype, POEMS, plasma cell leukemia Multiple myeloma of IgM subtype, POEMS, plasma cell leukemia