Participants with a personal or family history of long QT syndrome Participants with a personal or family history of long QT syndrome Participants with a personal or family history of long QT syndrome. History of personal psoriasis. Personal history of endometrial cancer or any abnormal uterine bleeding Family or personal history of long QT syndrome Personal history of Gilbert’s syndrome Personal or family history of bleeding diathesis and a coagulation profile that would preclude patient from undergoing a neurosurgical procedure Personal or family history of severe sickle cell disease or variant (unless donor has tested negative); testing for the presence of hemoglobin S is not required Patients with personal or family history of bleeding disorders are not eligible Personal or family history of long QT syndrome Known personal history of >3 adenomatous colorectal polyps or a personal history of adenomatous colorectal polyp(s) >2 centimeters (cm) in size Personal or family history of long QT syndrome Personal or family history of established Brugada syndrome; if pre-enrollment electrocardiogram (ECG) demonstrates abnormal findings (ST elevation in precordial leads), cardiology consultation should be obtained to rule out presence of this inherited syndrome; patients with family history of unexplained sudden death before the age 45 years; personal history of unexplained syncope or history of unexplained ventricular tachycardia or fibrillation should have a cardiology evaluation to rule out the diagnosis of Brugada syndrome Personal or family history of long QT syndrome History of clinically significant cardiac disease, including but not limited to a history (personal or family) of congenital long QT syndrome Subjects must have a personal mobile device compatible for the activity monitor A personal history of colorectal cancer Documented wish against transfusion for personal or religious beliefs Personal history of migraine, cluster or tension headaches Individuals who have a personal history of hereditary breast or ovarian cancer\r\n* A subset of 60 women without a personal history of hereditary or ovarian cancer will be included in an exploratory subset analysis Personal history of an eating disorder A personal history of cancer, tumor, or a related illness Unwilling to use personal phone/tablet to test intervention Personal history of ovarian cancer Must be willing to complete demographic, family history, personal health and medication history, and informed consent Known personal history of prostate cancer Individuals that have a personal or family history of CRC (previous adenomatous polyp), and/or, have a signs and symptoms colonoscopy order from their primary care physician Personal or family history (1st degree relative) of colon cancer WHITE, NON-HISPANIC: Without a personal history of melanoma. H/L: Without a personal history of melanoma and without a personal history of more than one squamous cell carcinoma (SCC) and/or basal cell carcinoma (BCC). H/L: Participants with a personal history of melanoma and/or more personal history of more than one SCC and/or BCC. Have a personal history of melanoma and/or family history of melanoma (see definition under child eligibility criteria below) Personal history of polyps Personal history of CRC Personal or family history of porphyrias Personal or family history of porphyrias Personal or family history of porphyrias Personal history of hepatitis or other liver diseases A personal history of CRC Ability to understand and the willingness to use the PMSA on the patient’s personal smartphone Personal phone with SMS text messaging capability A personal email address