Clinically significant or uncontrolled cardiac disease. Serious co-morbid medical conditions, including clinically-significant cardiac disease History of clinically significant cardiac dysfunction Clinically significant cardiac disease. History of clinically significant cardiac dysfunction History of clinically significant cardiac disease; uncontrolled hypertension Clinically significant cardiac disease History of clinically significant cardiac or pulmonary dysfunction as specified in antecedent study History of clinically significant cardiac dysfunction History of autoimmune disease, clinically significant cardiac or pulmonary dysfunction Clinically significant cardiac disease. Clinically significant, uncontrolled heart disease and/or recent cardiac event (within 6 months prior to randomization) Active or clinically significant cardiac disease. History of clinically significant or uncontrolled cardiac disease including but not limited to: History of clinically significant cardiac dysfunction Patients must not have clinically significant cardiac disease. Clinically significant cardiac disease Documented clinically significant cardiac arrhythmias Have a significant cardiac condition. Active or clinically significant cardiac disease clinically significant cardiac disease Subjects with clinically significant uncontrolled cardiac disease Clinically significant cardiac disease History or current diagnosis of cardiac disease indicating significant risk of safety for patients participating in the study such as uncontrolled or significant cardiac disease Clinically significant or uncontrolled cardiac disease. Clinically significant cardiac disease History of clinically significant cardiac disease Clinically significant cardiac disease as per protocol-defined criteria. Have clinically significant cardiac disease Sustained or clinically significant cardiac arrhythmias Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality, or clinically significant cardiac arrhythmias Significant history or risk of cardiac disease Has clinically significant cardiac disease History of clinically significant or uncontrolled cardiac, hepatic, or pulmonary disease Significant active cardiac disease within the previous 6 months Has clinically significant cardiac disease Clinically significant cardiac disease Clinically significant cardiac disease Clinically significant cardiac or pulmonary dysfunction Significant active cardiac disease within the previous 6 months, including: Clinically significant, uncontrolled heart disease and/or recent cardiac repolarization abnormality including any of the following: Clinically significant active cardiac disease, uncontrolled heart disease and/or history of cardiac dysfunction including any of the following Clinically significant (i.e. active) cardiac disease (e.g. symptomatic coronary artery disease, uncontrolled cardiac arrhythmia, or myocardial infarction within the last 6 months); any history of clinically significant cardiac failure Active or clinically significant cardiac disease including: Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality Uncontrolled or significant cardiac disease Clinically significant or uncontrolled hypertension or cardiac disease Have clinically significant cardiac disease History of clinically significant cardiac or pulmonary dysfunction Clinically significant, uncontrolled heart disease and/or recent cardiac event within 6 months prior to study No clinically significant cardiac conduction disorder on screening. History of clinically significant or uncontrolled cardiac disease. Significant cardiac impairment Significant cardiac disease within 6 months Clinically significant cardiac disease as defined in the protocol Clinically significant cardiac disease Significant cardiac disease Evidence or history of significant cardiac disease Clinically significant cardiac disease Significant cardiac events History of clinically significant cardiac disease Clinically significant, uncontrolled heart disease and/or recent cardiac events. Clinically significant cardiac disease History of clinically significant cardiac dysfunction Clinically significant cardiac disease, including: Have clinically significant cardiac disease Clinically significant cardiac disease Uncontrolled systemic disease (e.g., clinically significant cardiac, pulmonary or metabolic disease) Significant history of cardiac disease History of clinically significant cardiac disease. Significant history of cardiac disease Clinically significant cardiac disease; Clinically significant cardiac or pulmonary dysfunction Significant active cardiac disease within the previous 6 months: Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality, or clinically significant cardiac arrhythmias History of clinically significant cardiac or pulmonary dysfunction Sustained or clinically significant cardiac arrhythmias Any clinically significant comorbidities, such as uncontrolled pulmonary disease, known impaired cardiac function or clinically significant cardiac disease (specified below), active CNS disease, active infection, or any other condition that could compromise the participant's participation in the study. Clinically significant cardiac disease Subjects with clinically significant uncontrolled cardiac disease Clinically significant cardiac or pulmonary disease Significant active cardiac disease within the previous 6 months, including: History of clinically significant or uncontrolled cardiac disease. Clinically significant cardiac disease within last 12 months History of clinically significant or active cardiac disease Clinically significant, uncontrolled heart disease and/or recent cardiac event (within 6 months History of clinically significant cardiac dysfunction