Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents while on study Patients may not be receiving any other investigational agents while on study Patients must not be receiving or planning to receive any other investigational agents Patients may not be receiving any other investigational agents while on study treatment Patients receiving ongoing treatment with any other investigational agents are not eligible Patients may not be receiving any other investigational agents Patients may not be receiving or have received any other investigational agents during/or within 1 month prior Patients receiving any other investigational agents are ineligible Patients receiving any other investigational agents are excluded Subjects who are receiving any other investigational agents EXCLUSION CRITERIA FOR THIRD-LINE THERAPY: Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patient is receiving any other investigational agents. Patients who are receiving any other investigational agents Patients receiving ongoing treatment with any other investigational agents are not eligible Receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents. Receiving any other investigational agents Patients must not be receiving any other investigational agents Receiving any other investigational agents for their lymphoma Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational therapy Patients who are receiving any other investigational agents Patients receiving any other investigational agents are excluded Patients receiving any other investigational agents Patients may not be receiving any other anti-neoplastic investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other therapeutic investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents, or have received investigational agents within 4 weeks of beginning treatment Patients may not be receiving (or received prior to enrollment) any other investigational agents for metastatic disease. Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents for treatment of their kidney cancer Patients who are receiving other investigational agents Patients who are actively receiving any other investigational agents Patients who are receiving any other investigational agents Patient must not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents or other tumor-directed therapy. Patients who are receiving any other investigational agents Patients receiving other investigational agents. Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patient is receiving other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents for the treatment of their breast cancer Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other anticancer or investigational agents Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents within 30 days of registration Patients must not be receiving any other investigational agents Patients receiving other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Subjects who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents =< 28 days prior to study treatment Patients receiving any other investigational agents within 30 days of receiving zydelig Patients who are receiving any other investigational agents Subjects receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Subjects who are receiving any other investigational agents Patients receiving other investigational agents Patients receiving any other investigational agents Patients who are receiving any investigational agents Patients who are receiving any other investigational agents or other tumor-directed therapy Patients receiving any other investigational agents Subjects may not be receiving any other investigational agents Patients who are receiving any other investigational agents within 28 days before start of study treatment Subjects may not be receiving other investigational agents Patients may not be receiving any other investigational agents =< 14 days from registration Patients who are receiving any other investigational agents or have within the last 28 days Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Subjects receiving any other investigational agents Receiving any other investigational agents within 14 days prior to enrollment Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects receiving other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents (with exception of imaging agents) Patients who are receiving any other investigational agents; however, prior enrollment on a study using investigational agents is acceptable Patients who are receiving any other investigational agents within the preceding 4 weeks Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients receiving any investigational agents Patients receiving any other investigational agents Patients receiving any other investigational agents or immunotherapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents within the preceding 4 weeks Subjects receiving any other investigational agents Patients who are receiving any investigational agents Patients who are receiving any investigational agents Patients may not be receiving any other investigational agents Subjects who are actively receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Subjects who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents nor have participated in an investigational trial within the past 4 weeks Subjects who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational therapeutic agents Subjects may not be receiving any other investigational agents Patients who are receiving other investigational therapeutic agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Subjects is receiving any other investigational agents for the treatment of prostate cancer Patients may not be receiving any other investigational agents Subjects must not be receiving any other investigational agents Patients receiving any other investigational agents. Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents and/or other therapy for their cancer Patient must not be receiving any other investigational agents Patients may not be receiving any other investigational cancer treatment agents at the time of enrollment Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Receiving any other investigational agents =< 28 days prior to registration Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible The subject is receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents TUMOR BIOPSY SEQUENCING: Patients who are receiving any other investigational agents; patients on other trials will be eligible as long as they are no longer receiving study treatment TREATMENT: Patients who are receiving any other investigational agents; patients on other trials will be eligible as long as they are no longer receiving study treatment Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients must not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other biologic, cytotoxic or investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within 14 days of enrollment Subjects may not be receiving any other investigational agents Patients receiving any other investigational agents Receiving other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any additional investigational agents or radiation therapy Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents for melanoma Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within 14 days of enrollment Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents are not eligible Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents PHASE II: Patients may not be receiving any other investigational agents while on study Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents May not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents for cancer Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subject who is receiving any other investigational agents; Patients who are receiving any other investigational agents Not receiving any other investigational agents Patients may not be receiving any other investigational agents Patients must not be receiving any other investigational agents Subjects receiving any other investigational agents Receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within 14 days of enrollment Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Receiving any other investigational agents at the time of registration Patients who are receiving any other investigational agents Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Subjects receiving any other investigational agents Patients may not be receiving any other investigational agents within 2 weeks prior to registration Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patient receiving any other investigational agents Patients may not be receiving any other investigational cancer-directed agents Actively receiving any investigational agents Patients receiving any other investigational agents within 30 days prior to the first dose of trial treatment Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving other investigational agents Patients who are receiving any other investigational agents Subjects receiving other investigational agents are not eligible Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within 14 days of enrollment Patients may not be on any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Subjects may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients should not be receiving any other investigational agents Ongoing therapy with other investigational agents. Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Patients receiving any other investigational agents for cancer treatment Patients may not be receiving any other investigational agents while on study treatment Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents while on study Patient receiving any other investigational agents Patient must not be receiving any other investigational agents Patients who are receiving any investigational agents Patient must not be receiving any other investigational agents Patients who are receiving any investigational agents. Patients may not be receiving any other investigational agents Patients receiving any other chemotherapy or investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Subjects receiving any other investigational agents Subjects receiving other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents Patients receiving other investigational agents Receiving any other investigational agents Patients may not be receiving any other investigational agents Patients should not be receiving any other investigational agents Patients should not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or other medications for the treatment of their malignancy Patients receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or have received immunotherapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within 14 days of enrollment Patients may not be receiving any additional investigational agents or radiation therapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents within 28 days before start of study treatment Patients should not be receiving any other investigational agents Patients may not be receiving any investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patient must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents are ineligible Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients planning on receiving other investigational agents while on this study Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or have received other investigational agents for at least 3 weeks Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents within 7 days of registration Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Subjects may not be receiving any investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patient must not be receiving any other investigational agents Patient must not be actively receiving any other investigational agents Receiving any other investigational agents =< 6 months prior to registration Receiving any other investigational agents =< 6 months prior to Registration Receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Receiving any other investigational agents Receiving any other investigational, anticoagulation, and/or chemotherapy agents Participant is receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients may not be receiving any other investigational agents Receiving any other investigational agents Patient may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Women who are receiving any other investigational agents Receiving any investigational agents Subjects may not be receiving any investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents within 4 weeks of starting the study Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving Patients who are receiving any other investigational agents