Patients with symptomatic peripheral vascular disease are not eligible Patients with history of active collagen vascular disease Symptomatic peripheral vascular disease No symptomatic peripheral arterial disease Patients with known cardiac disease per the New York Heart Association definition such as myocardial infarction, severe or unstable angina, peripheral vascular disease, or congestive heart failure or peripheral vascular disease are not eligible ischemic peripheral vascular disease, myocardial infarction within the past 6 months, Known active collagen vascular disease Active collagen vascular disease systemic vascular disease or vasculitis Vascular invasion Any history of peripheral vascular infarction, including visceral infarction Subject has a grade II or greater peripheral vascular disease Clinically significant peripheral vascular disease Symptomatic peripheral vascular disease Clinically significant peripheral vascular disease Symptomatic systemic vascular disease is defined as cardiovascular disease which prevents any procedure in MRI where ECG cannot be obtained (i.e. coronary disease). These patients must be excluded Severe peripheral vascular disease that would preclude catheterization Severe peripheral vascular disease that would preclude catheterization History of stroke, coronary arterial disease, angina, or vascular disease Subjects with prosthetic cardiac valves, vascular grafts, pacers, or other non-removable vascular foreign body, with the exception of coronary stents and peripheral stents; Has arterial vascular involvement Active collagen-vascular disease Patients who had, within the past 6 months, a cardiovascular accident (CVA) or at risk for arterial thrombus such as severe peripheral vascular disease (PVD) and carotid artery disease (CAD) Clinically significant peripheral vascular disease Symptomatic peripheral vascular disease Patients are excluded if they have symptomatic peripheral vascular disease Patients with active vascular disease, either myocardial or peripheral (i.e. acute coronary syndrome, cerebral stroke, transient ischemic attack or arterial thrombosis or symptomatic peripheral vascular disease within the past 3 months); Patients with known proliferative and/or vascular retinopathy; Clinically significant peripheral vascular disease Patients with clinically significant peripheral vascular disease Symptomatic peripheral vascular disease Has any condition known to effect wound healing, such as collagen vascular disease No severe peripheral vascular disease Symptomatic peripheral vascular disease Significant vascular disease Significant vascular disease Subject either currently has central vascular access or is a candidate to receive central vascular access or peripheral vascular access for leukapheresis procedure. Patients with symptomatic peripheral vascular disease are ineligible Clinically significant peripheral vascular disease Patients with symptomatic peripheral vascular disease are not eligible Symptomatic arterial peripheral vascular disease None of the following conditions within 6 months prior to enrollment: myocardial infarction, stroke or symptomatic peripheral vascular disease None of the following conditions within 6 months prior to enrollment: myocardial infarction, stroke or symptomatic peripheral vascular disease Subjects with benign vascular tumor Clinically significant peripheral vascular disease Symptomatic peripheral vascular disease Subject has a grade II or greater peripheral vascular disease Clinically significant peripheral vascular disease Significant cardiac or peripheral vascular arterial disease Subject has peripheral vascular disease Clinically significant peripheral vascular disease History of significant vascular disease. Significant vascular disease Severe peripheral vascular disease in subjects whose Study Lesions are located in an extremity Significant vascular disease. CTCAE grade 3 or greater peripheral vascular disease Neurologic, metabolic, or vascular diseases that may negatively impact erectile function, such as: diabetes mellitus, peripheral vascular disease, coronary artery disease, stroke, multiple sclerosis, Parkinson’s disease, multiple systems atrophy, epilepsy, or spinal cord injury. Vascular disease resulting in clinically apparent compromise in blood flow to the treatment extremity (i.e. peripheral vascular disease with diminished pulses, venous insufficiency with clinical evidence of vascular congestion) Active collagen vascular disease Patients with collagen vascular disease are excluded No symptomatic peripheral vascular obstructions Previous diagnosis of collagen vascular disorder or vasculitis The subject has a history of peripheral vascular disease A history of cardiovascular disease, hypertension, or peripheral arterial/vascular disease; Subject has known lympho-vascular invasion Hospitalization in the past 2 months for any cardiovascular disease, including but not limited to:\r\n* Angina\r\n* Myocardial infarction\r\n* Peripheral vascular disease\r\n* Stroke Participants with known active collagen vascular disease Measurable hepatic disease and/or presence of vascular tumor thrombosis Participants with known active collagen vascular disease Have collagen vascular disease