No active, second potentially life-threatening cancer Patients with significant autoimmune disease that is active or potentially life threatening if activated Patients with a history of life-threatening autoimmune disease Active life-threatening autoimmune disease An active, second potentially life-threatening cancer Patients with significant autoimmune disease that is active or potentially life threatening if activated Patients with a history of life-threatening autoimmune disease Serious and potentially life-threatening arrhythmia.