Have initiative and means to be compliant with protocol and within geographical proximity to make required study visits as judged by Investigator Compliant on combined anti-retrovirals (cART) if HIV infected Not compliant with anti-retroviral therapy (HIV infected participants) Any patients who cannot be compliant with the appointments required in this protocol must not be enrolled in this study. Patient (Pt) may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant Pt may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant Any patient who cannot be compliant with the appointments required in this protocol must not be enrolled in this study Any patients who cannot be compliant with the appointments required in this protocol must not be enrolled in this study PART 1 EXCLUSION CRITERIA: Potential subjects and/or parents/guardians who, in the opinion of the investigative team, are likely to be non-compliant with study schedules or procedures PART 2 GROUP 1 EXCLUSION CRITERIA: Potential subjects and/or parents/guardians who, in the opinion of the investigative team, are likely to be non-compliant with study schedules or procedures PART 2 GROUP 2A EXCLUSION CRITERIA: Potential subjects and/or parents/guardians who, in the opinion of the investigative team, are likely to be non-compliant with study schedules or procedures PART 2 GROUP 3 EXCLUSION CRITERIA: Potential subjects and/or parents/guardians who, in the opinion of the investigative team, are likely to be non-compliant with study schedules or procedures Patient, in the opinion of the investigator, is likely to be poorly compliant Any patients who cannot be compliant with the appointments required in this protocol must not be enrolled in this study Non-compliant to medications Non-compliant to medications Patient is deemed by the investigator to have the initiative and means to be compliant with the protocol (treatment and follow-up) All patients must be deemed by investigator to have the initiative and means to be compliant with the study protocol (treatment and follow-up) Patient (Pt) may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the pt is not capable of being compliant Patients must be, in the opinion of the Investigator, available and compliant for treatment and follow-up. Patient, in the opinion of the investigator, is likely to be poorly compliant Patient has been compliant with therapy per treating physician Patient may be excluded if, in the opinion of the principal investigator (PI) and investigator team, the patient is not capable of being compliant Patient is deemed by the investigator to have the initiative and means to be compliant with the protocol (treatment and follow-up) Donor must demonstrate ability to be compliant with study regimen. Recipient must demonstrate ability to be compliant with medical regimen. Patient is deemed by the Investigator to have the initiative and means to be compliant with the protocol (treatment and follow-up) Non-compliant to medications Unlikely to be compliant with the study intervention The patient and/or parents/caregivers are expected by the Investigator to be non-compliant with the study procedures. Psychosocial issues: no appropriate caregivers identified, or non-compliant to medications Participant has a known diagnosis of mental incapacitation that may affect their ability to consent and be compliant with the protocol Patient is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits Patient is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits INCLUSION CRITERIA (NEXT 60 PATIENTS WITH LOCALLY ADVANCED PROSTATE CANCER): Patient is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits Patient is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits has the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits Subject is judged by the investigator to have the initiative and means to be compliant with the protocol and be within geographical proximity to make the required study visits