Known or suspected allergy to the investigational agent or any agent given in association with this trial. Known or suspected allergy to the investigational agent or any agent given in association with this trial Known or suspected allergy to lenvatinib or any agent given in the course of this trial Known or suspected allergy to sorafenib, everolimus, or any agent given in the course of this trial History of ? grade 3 allergic reactions to monoclonal antibody therapy as well as known or suspected allergy or intolerance to any agent given in the course of this trial. Known or suspected allergy to any agent given in the course of this trial Known or suspected allergy to sorafenib or any agent given in the course of this trial Known or suspected allergy to the investigational agent or any agent given in association with this trial Known or suspected allergy to sorafenib or any agent given in the course of this trial Known or suspected allergy to gemcitabine or MLN8237, or any agent given in the course of this trial Known or suspected allergy to irinotecan or MLN8237, or any agent given in the course of this trial Known or suspected allergy to sorafenib (BAY 43-9006) or any agent given in association with this trial Known or suspected allergy to the investigational agent or any agent given in association with this trial. Known or suspected allergy to sorafenib Known or suspected allergy to sorafenib or any agent given in the course of this trial Known or suspected allergy to any agent given in the course of this trial