Current use of tobacco product other than cigarettes (e.g. e-cigarettes, smokeless tobacco) Smoke at least 5 cigarettes/day or carbon monoxide (CO) reading of at least 8 ppm Daily use of a second form of tobacco or nicotine (e.g. e-cigarettes, cigars, chewing tobacco, snuff) Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study Smoke an average of 5 or more cigarettes or little cigars per day (CPD) prior to telephone screen Smoked at least 10 cigarettes/day for at least 1 year. Concurrent use of tobacco products (other than cigarettes) or nicotine products. Non-smokers, former smokers and/or smokers who have not smoked within 1 month before surgery, and who agree to not smoke or utilize e-cigarettes during the post-operative period Willing not to smoke Regular or sporadic use of nicotine cigarettes (> 1 cigarettes in the past 30 days) Patients may not smoke or plan to smoke tobacco or marijuana during study therapy PART I: Participants who smoke tobacco products will not be allowed to participate PART II: Those who smoke tobacco products will not be allowed to participate Smoked an average of less than 10 cigarettes per day during past month Patient participants must also be a current smoker, defined as anyone who responds “every day” or “some days” to the question: “Do you smoke cigarettes every day, some days, or not at all?” (Behavioral Risk Factor Surveillance System [BRFSS]) Individuals who use e-cigarettes and who are not smoking cigarettes; dual users (those who use both e-cigarettes and cigarettes) will be included in the trial Regular use of tobacco products other than cigarettes Smoke >= 5 cigarettes (cig)/day during the last week Individuals with a history of diabetes, hypertension, or have smoked cigarettes in the last 12 months. Smokes a minimum of 3 cigarettes per day over the past year. Smoke >= 10 cigarettes per day Smoke >= 10 cigarettes per day for the last 6 months Current smokers (smoked at least 100 lifetime cigarettes and currently smoke on some or every day) who would like help quitting Exclusive use of tobacco products other than cigarettes, such as (but not limited to) cigars, chew, snuff, pipe or electronic (e)-cigarettes (cigs). Smoking >= 5 tobacco cigarettes/week over the past year Smoke at least 5 cigarettes daily for the past year Ever used reduced nicotine cigarettes Smoke ‘roll your own’ cigarettes exclusively Used other tobacco products (including e-cigarettes) more than 9 days in the past month Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes, little cigars or cigarillos on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study Have smoked cigarettes or used any other tobacco product in the past 30 days (i.e., pipe, cigar) and unwilling to stop use for the study period Smokes >= 1 cigarettes per day (cpd) Use of tobacco products other than cigarettes in past 30 days Active use or recent use (=< to 1 month) of medication or e-cigarettes for nicotine dependence/smoking cessation, or use of e-cigarettes for more than 9 days in the prior month Smoke at least weekly Regular use of any form of tobacco other than cigarettes; Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes, little cigars or cigarillos on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study Smoke one or more cigarettes on 25 out of the past 30 days Current moderate-to-heavy smoker as determined by:\r\n* Has smoked greater than or equal to 10 cigarettes per day regularly for the past year (by history) (greater than or equal to 5 cigarettes per day for study 2) and,\r\n* Has an expired carbon monoxide (CO) at screening visit of 8 ppm or more (6 ppm or more for study 2) Smoke at least 10 cigarettes daily for the past year Smoke 5 or more cigarettes/day Smoke cigarettes 25 of the past 30 days (not including days spent in the hospital) Have smoked 100 cigarettes in their lifetime and currently smoke five or more cigarettes a day on average STUDY I: Current dual users (of tobacco cigarettes and e-cigarettes) without interest in quitting smoking STUDY II: Using e-cigarettes at least once per week over the past month Currently smoke at least 5 cigarettes per day Smoked at least 100 cigarettes in lifetime Current use of >= 5 cigarettes/day Smoke 3-20 cigarettes per day (cpd) Use of tobacco products other than cigarettes in past 30 days For traditional cigarettes (TC) smokers, daily TC smoking in the past 6 months, at least 10 cigarettes per day, with no EC exposure in the past 6 months HEALTHY VOLUNTEER: Use of more than 5 cigarettes/day Use of tobacco- or nicotine-containing products in excess of the equivalent of 5 cigarettes per day Smoke at least five cigarettes daily for the past year Willing to use electronic (e)-cigarettes Use in the past 30 days of tobacco or nicotine products including e-cigarettes, other than regular cigarettes Current use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes) or use of these products within 3 months of study registration Regular use (e.g., greater than weekly) of tobacco products (including e-cigarettes) other than cigarettes Use of > 25% of cigarettes in the form of roll-your-own cigarettes unless they are machine rolled and include a filter Use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes) Willingness to try novel cigarettes Current, regular (i.e., monthly or more) use of nicotine replacement or other tobacco products, by self-report (e-cigarette users will be excluded if their average monthly use exceeds half of their average monthly use of conventional tobacco cigarettes) Exclusive use of roll-your-own cigarettes (since the study uses manufactured cigarettes); and cannot be currently smoking more than 1/3 of roll your own cigarettes Identification of cost being the primary reason why person does not smoke daily (so that the study outcome variable of smoking rate isn’t influenced by participant receiving research cigarettes)