Patients must have no known allergies to exemestane, entinostat, or medications that have a benzamide structure (e.g., tiapride, remoxipride, clebropride) Known allergies to carfilzomib or Captisol History of any drug allergies or significant adverse reactions to any of the components of SM-88. Patients with known and documented allergies to any of the penicillins, cephalosporins, or beta-lactamase inhibitors Known allergies to medical adhesives or hydrogel Known allergies to medical adhesives or hydrogel History of allergies to any active or inactive ingredients of atezolizumab. Patients who cannot tolerate pneumocystis jirovecii pneumonia (PJP) prophylaxis (i.e., known Bactrim and pentamidine allergies) Patients with known or suspected allergies to any component of the vaccine. ALLERGIES AND ADVERSE DRUG REACTION Known allergies to medical adhesives or hydrogel Patients with known contrast allergies requiring pre-medication with steroids Known allergies, hypersensitivity or intolerance to apalutamide, abiraterone acetate, prednisone, or GNRH agonist or GNRH antagonist Subjects with three or more drug allergies from separate drug classes History of multiple drug allergies or intolerance to subcutaneous injections Subjects with three or more drug allergies from separate drug classes Allergies, hypersensitivity, or intolerance to prednisone, LHRH analog or excipients of prednisone LHRH analog, abiraterone acetate and apalutamide. Allergies to any vaccine, that after discussion with Immunovaccine, are serious enough to warrant exclusion from this study Prior use of niclosamide or allergies to niclosamide Allergies and adverse drug reaction Allergies to Lidocaine or Novocain Allergies to imaging dyes Documented penicillin or cephalosporin allergies Subjects with any underlying conditions, which would contraindicate therapy with, study treatment (or allergies to reagents used in this study) Known allergies to any of the components of the investigational treatment regimen or required ancillary treatments Patients with NSAIDs allergies, known lactose allergy, a history of recent gastrointestinal (GI) bleed (less than 2 weeks), and those who are on therapeutic dose anticoagulants will be excluded from this protocol Patients with allergies to any component of the vaccine will be excluded from the protocol Subjects must not have allergies to any compounds similar to CDB-4124 Allergies to lidocaine or marcaine Allergies to imaging dyes Known history of allergies or sensitivities to gentamicin. Patients with allergies to isosulfan blue or technetium, which would preclude sentinel node mapping Antibiotic allergies that would preclude treatment for a C. novyi-NT infection Participants with known or suspected allergies to any component of the vaccine Known allergies to clofarabine, melphalan, sirolimus or tacrolimus Allergies or hypersensitivities to monoclonal antibodies, BMS-986012 or related compounds, including fucosyl-GM1 vaccine and Nivolumab Subjects with any known severe allergies (e.g. anaphylaxis) to any active or inactive ingredients in the study drugs. Known allergies, hypersensitivity, or intolerance to any form of heparin or azacitidine No eating disorders, food allergies or intolerances Any prior allergies to curcumin or turmeric Known allergies to any of the components of the investigational treatment regimen or required ancillary treatments Any history of allergies to grapes or grape seed Known allergies, hypersensitivity or intolerance to abiraterone acetate, prednisone or degarelix Subjects with any underlying conditions which would contraindicate therapy with study treatment (or allergies to reagents) Subject has any underlying conditions, which would contraindicate therapy with study treatment (or allergies to reagents used in this study) Antibiotic allergies that would preclude treatment for a C. novyi-NT infection. Allergies to excipients in the study drug. Hypersensitivities, allergies or contraindications to study medications; intolerance of medical tape or sticking plaster. Allergies to temozolomide, dacarbazine, IgG containing agents Allergies and Adverse Drug Reaction Allergies to any component of the vaccine Known allergies, hypersensitivity, or intolerance to dacarbazine does not apply Allergies to eggs, lecithin or soy products. No allergies to and not currently using varenicline Significant food allergies which would make the subject unable to consume the food provided (soy or nut allergy) Patients with known allergies to egg products, neomycin, or tetanus toxoid Subjects with allergies to any supplements. Patients with allergies to any of the ingredients in the nutritional supplement Milk protein intolerance/allergies (lactose intolerance is acceptable) Known allergies or intolerance to cisplatin and similar platinum-containing compounds Allergic history, including anaphylaxis or severe allergies to products in study serum or placebo Has known allergies or intolerance to brilacidin, cisplatin or carboplatin Patients will be excluded from the trial if they have had a history of allergies or intolerance to fructooligosaccharides or the components of FOS including fructose and glucose Known allergies or intolerance to cisplatin and similar platinum-containing compounds Known allergies, hypersensitivity, or intolerance to any of the study medications. Cutaneous photosensitivity to wavelengths of 400-450 nm, porphyria or known allergies to porphyrins All patients who are have known allergies or are sensitive to silver and acrylic adhesives Allergies to multiple food items or nutritional supplements History of food allergies and/or major dietary restrictions Subjects should not have known allergies to cruciferous vegetables No known allergies to tree nuts (i.e. almonds) Subjects with three or more drug allergies from separate drug classes Subjects with three or more drug allergies from separate drug classes No known allergies to contrast material No known allergies to contrast material Known allergies to contrast material History of allergies to iodides Subjects with a history of iodide allergies Allergy to gadolinium or other severe drug allergies Subjects with three or more drug allergies from separate drug classes Patients with allergies to iodinated contrast not amenable to pre-medication History of allergies and adverse drug reaction to study drug components Subjects with three or more drug allergies from separate drug classes Allergies to study medications, such as, lidocaine, Versed, or Cetacaine Allergies and Adverse Drug Reaction a. Subjects with known hypersensitivity to excipients of Dasatinib tablets