Subject must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after alisertib administration Willing to fast for 6 hours before and 2 hours after Oradoxel administration Ability to swallow oral medications and maintain an empty stomach state for 2 hours prior to the MLN0128 dose and for 1 hour following administration Ability to swallow oral medications and maintain an empty stomach state for two hours prior to the TAK-228 dose and for one hour following administration Must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after capsule(s) administration Subject must be able to take oral medication and to maintain a fast, as is required for 2 hours before and 1 hour after alisertib (MLN8237) administration According to current guidelines, patients must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration; these guidelines may change pending results from an ongoing food effects study Patients must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration Inability to swallow oral medication or to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration or any condition that would modify small bowel absorption of oral medications, including malabsorption, or resection of pancreas or upper bowel Ability to swallow oral medications and maintain an empty stomach state for 2 hours prior to the MLN0128 dose and for 1 hour following administration Inability to swallow oral medication or to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration or any condition that would modify small bowel absorption of oral medications, including malabsorption, or resection of pancreas or upper bowel Patient must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration Able and willing to swallow and absorb orally administered medications and maintain a fast as required before and after MLN8237 administration Subject must be able to take oral medication and to maintain a fast as required before and after MLN8237 administration Subjects must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration Subjects must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration. According to current guidelines, patients must be able to take oral medication and to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration; these guidelines may change pending results from an ongoing food effects study Inability to swallow oral medication or to maintain a fast as required for 2 hours before and 1 hour after MLN8237 administration or any condition that would modify small bowel absorption of oral medications, including malabsorption, or resection of pancreas or upper bowel