Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) must be within the range allowing for eligibility, must be obtained < 2 weeks prior to randomization Within less than or equal to 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 1.5 x institutional ULN, within 21 days prior to registration Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 x ULN within 90 days prior to Step 1 registration Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN within 28 days prior to step 1 registration Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN within 28 days prior to step 3 registration Aspartate aminotransferase (AST) =< 2.5 x ULN obtained within 14 days prior to registration Alanine aminotransferase (ALT) =< 2.5 x ULN obtained within 14 days prior to registration Obtained within 14 days prior to C1D1: Aspartate aminotransferase (AST) =< 3 x ULN Obtained within 14 days prior to C1D1: Alanine aminotransferase (ALT) =< 3 x ULN Obtained =< 2 weeks prior to registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x ULN (=< 5 x ULN if liver metastasis) Obtained within 28 days prior to registration: Aspartate aminotransferase (AST) =< 5 x ULN Obtained within 28 days prior to registration: Alanine aminotransferase (ALT) =< 5 x ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN, within 14 days prior to registration OBTAINED =< 7 DAYS PRIOR TO REGISTRATION: Aspartate aminotransferase (AST) =< 2 x ULN Obtained =< 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN Aspartate aminotransferase (AST) =< 2.5 × ULN obtained within 14 days prior to initiating study treatment. Alanine aminotransferase (ALT) =< 2.5 × ULN obtained within 14 days prior to initiating study treatment. Obtained ? 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ? 2.5 x ULN Obtained within 28 days prior to registration: Aspartate aminotransferase (AST) =< 3 x ULN Obtained within 28 days prior to registration: Alanine aminotransferase (ALT) =< 3 x ULN Obtained within 14 days prior to randomization/registration: aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN Obtained within 28 days prior to the first dose of cabozantinib: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3.0 x ULN. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x ULN, obtained within 7 days prior to first study treatment Aspartate aminotransferase (AST) =< 2.5 x ULN (obtained within three days prior to study treatment) Alanine aminotransferase (ALT) =< 2.5 x ULN (obtained within three days prior to study treatment) Obtained within 21 days prior to randomization/registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN. Within 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN Obtained =< 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN or < 5 x ULN if liver involvement Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN within 14 days prior to Step 2 registration Within 14 days prior to registration: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), =< 3 x ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2 x upper limit of normal (ULN) obtained =< 14 days prior to registration\r\n* NOTE: if baseline liver disease, Child Pugh score not exceeding class A Aspartate aminotransferase (aspartate transaminase [AST]) and alanine aminotransferase (alanine transaminase [ALT]) =< 2.5 x ULN OR =< 5 X ULN for patients with liver metastases (obtained =< 14 days prior to registration) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN, obtained =< 14 days prior to registration Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN should be obtained within 21 days prior to enrollment Aspartate aminotransferase =< 2.5 x institutional ULN obtained within 14 days of first treatment Alanine aminotransferase =< 2.5 x institutional ULN obtained within 14 days of first treatment Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN obtained within 14 days prior to randomization/registration Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN, obtained within 30 days of study registration Aspartate aminotransferase (AST) =< 1.5 x ULN, obtained =< 14 days prior to registration Within 14 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x ULN Alanine aminotransferase (ALT) and aspartate transaminase (AST) =< 3 x ULN (=< 5 x ULN for patients with liver involvement), obtained =< 14 days prior to registration Obtained =< 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN Within 14 days prior to registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN Obtained ? 14 days prior to registration: aspartate transaminase (AST) and alanine aminotransferase (ALT) ? 3 x ULN Obtained =< 21 days prior to registration: Aminotransferase (ALT) =< 3.0 x ULN, =< 5.0 x ULN for patients with metastatic disease to the liver Aspartate transaminase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN OR =< 5 x ULN for subjects with liver metastases obtained =< 28 days prior to registration Aspartate aminotransferase (aspartate transaminase [AST]) =< 2.5 x ULN, obtained =< 7 days prior to registration Alanine aminotransferase (alanine transaminase [ALT]) =< 2.5 x ULN, obtained =< 7 days prior to registration Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x institutional ULN within 14 days prior to registration ARM A: obtained =< 14 days prior to registration: \r\nAspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 5 x ULN Obtained within 30 days prior to registration: Aspartate aminotransferase (AST) =< 1.5 x ULN Obtained within 30 days prior to registration: Alanine aminotransferase (ALT) =< 1.5 x ULN Obtained within 14 weeks prior to registration on study: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 2 x ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 4.0 x ULN obtained within 14 days prior to registration Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) obtained =< 14 days prior to registration Obtained =< 21 days prior to registration: Alanine aminotransferase (ALT) =< 3 x institutional ULN Obtained =< 7 days prior to registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x institutional ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN (obtained =< 14 days prior to registration) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN obtained =< 7 days prior to registration (=< 5 x ULN in patients with liver metastases) Obtained within 14 days prior to initiation of treatment: Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) < 2.5 times ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN, obtained within 14 days of the first dose of study drug Alanine aminotransferase (ALT) or aspartate transaminase (AST) =< 3 x upper limit of normal (ULN) obtained =< 30 days prior to registration Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 X ULN, obtained within 14 days prior to PET scan Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2.5 x ULN obtained < 2 weeks prior to study enrollment Alanine and aspartate aminotransferase (ALT/AST) =< 2.5 x upper limit of normal (ULN) obtained =< 14 days prior to registration