No history of congenital prolonged corrected QT (QTc) syndrome, New York Heart Association (NYHA) class III or IV congestive heart failure (CHF) New York Heart Association (NYHA) class III or IV heart failure, uncontrollable supraventricular arrhythmias, any history of a ventricular arrhythmia, or other clinical signs of severe cardiac dysfunction New York Heart Association (NYHA) class II, NYHA class III, or IV congestive heart failure (any symptomatic heart failure) Congestive heart failure (CHF) New York (NY) Heart Association class III or IV Congestive heart failure (NYHA Class III or IV). New York Heart Association (NYHA) class III or IV congestive heart failure, ventricular arrhythmias or uncontrolled blood pressure Symptomatic congestive heart failure (CHF), New York Heart Association (NYHA) Class III or IV heart failure or other clinical signs of severe cardiac dysfunction Documented NYHA Class III or IV congestive heart failure, Current congestive heart failure (New York Heart Association Class II, III or IV) Participants with a history of congestive heart failure (New York Heart Association [NYHA] class II, III or IV) are excluded Symptomatic congestive heart failure of New York heart Association Class III or IV New York Heart Association (NYHA) class III or IV congestive heart failure. New York Heart Association class III or IV heart failure New York Heart Association Class II, III, or IV congestive heart failure New York Heart Association Class III or IV heart failure Participants with a history of congestive heart failure or New York Heart Association (NYHA) class III or IV functional status are excluded Congestive heart failure of New York Heart Association class III/IV, New York Heart Association (NYHA) Class III or IV heart failure New York Heart Association class III or IV heart failure Heart failure, class IV by New York Heart Association criteria Subjects with New York Heart Association (NYHA) class III or IV heart failure. Class II, III or IV heart failure as defined by the NYHA functional class system Patients must have a left ventricular ejection fraction >= 30%, no uncontrolled arrhythmias or New York Heart Association class III-IV heart failure New York Heart Association class III or IV heart failure New York Heart Association Class III to IV heart failure. New York Heart Association (NYHA) Class III or IV heart failure and/or ejection fraction of < 35% as measured by echocardiogram at screening. Absence of New York Heart Association (NYHA) class II, III, or IV congestive heart failure Congestive heart failure (CHF): New York Heart Association (NYHA) Class III (moderate) or Class IV (severe) at the time of screening New York Heart Association Class III or IV heart failure. Uncontrolled cardiac angina or symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV) NYHA Class III or IV heart failure, or reduced LVEF <50% History of congestive heart failure New York Heart Association (NYHA) class III or IV or uncontrolled hypertension at screening. New York Heart Association (NYHA) class IV heart failure NYHA Class III or IV heart failure congestive heart failure (New York Heart Association class III to IV) Subject has severe cardiovascular disease, i.e. arrhythmias, requiring chronic treatment, congestive heart failure (New York Heart Association [NYHA] class III or IV) or symptomatic ischemic heart disease Patients with moderate to severe heart failure, New York Heart Association (NYHA) class III or IV, liver dysfunction with total bilirubin > 2.5 upper limit of normal, or serum creatinine > 2.5 mg/dL or any form of dialysis; within 30 days prior to enrollment NYHA class IV heart failure Active congestive heart failure (New York Heart Association [NYHA] class III to IV), symptomatic ischemia, or conduction abnormalities uncontrolled by conventional intervention NYHA Class III or IV congestive heart failure, ventricular arrhythmias or uncontrolled blood pressure Congestive heart failure (New York Heart Association class III or IV) New York Heart Association class III/IV heart failure Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) New York Heart Association class III or greater congestive heart failure Patients with New York Heart Association (NYHA) class III or IV heart failure will be excluded Congestive heart failure (New York Heart Association [NYHA] II, III, IV) New York Heart Association (NYHA) Class III or IV heart failure, uncontrollable supraventricular arrhythmias, any history of a ventricular arrhythmia, or other clinical signs of severe cardiac dysfunction Documented NYHA Class III or IV congestive heart failure Congestive heart failure New York Heart Association (NYHA) Class III or IV or history of congestive heart failure NYHA class III or IV, unless an echocardiogram or multigated acquisition scan performed within 3 months before day 1 reveals a left ventricular ejection fraction ? 45%; Patients with congestive heart failure, Class III or IV, by New York Heart Association (NYHA) criteria. Patients with NYHA (New York Heart Association) class III or IV heart failure or history of a prior myocardial infarction (MI) within the last five years prior to enrollment in the study New York Heart Association (NYHA) stage III/IV congestive heart failure, arrhythmias not adequately controlled. History of symptomatic congestive heart failure (New York Heart Association [NYHA] Class III or IV). Congestive heart failure (New York Heart Association [NYHA] class III/IV) or left ventricular ejection fraction (LVEF) < 50% at baseline Heart failure that meets New York Heart Association (NYHA) class III and IV definitions Symptomatic congestive heart failure of New York Heart Association Class III or IV. Subjects with New York Heart Association (NYHA) Class III or IV congestive heart failure or LVEF <40% by echocardiogram (ECHO) or multi-gated acquisition (MUGA) scan within approximately 28 days of C1D1. For Cohort B:Has symptomatic congestive heart failure (New York Heart Association Class III or IV heart disease) Patients with New York Heart Association (NYHA) Class III or IV congestive heart failure or LVEF <40% by echocardiogram (ECHO) or multi-gated acquisition (MUGA) scan obtained within approximately 28 days of C1D1 History of class III or IV congestive heart failure, as defined by the New York Heart Association Classification of Congestive Heart Failure Congestive heart failure (New York Heart Association class III to IV) Class III or IV congestive heart failure per New York Heart Association New York Heart Association (NYHA) Class III or IV congestive heart failure; documented New York Heart Association (NYHA) Class III or IV congestive heart failure; New York Heart Association (NYHA) class III or IV congestive heart failure New York Heart Association (NYHA) class IV congestive heart failure New York Heart Association (NYHA) class III or IV congestive heart failure known autoimmune disease, known bleeding diathesis, history of congestive heart failure New York Heart Association (NYHA) class III or IV; New York Heart Association Class III or IV heart failure; Patients with class III or class IV heart failure by New York Heart Association, those with unstable angina, and those with uncontrolled arrhythmia are not eligible Subject has congestive heart failure classified as New York Heart Association Class IV. Congestive heart failure New York Heart Association (NYHA) Class III or IV or history of congestive heart failure NYHA Class III or IV in the past, unless a Screening echocardiogram or multi-gated acquisition scan performed within 3 months before the Day 1 visit reveals a left ventricular ejection fraction that is ? 45%. Congestive heart failure (CHF): New York Heart Association (NYHA) class III (moderate) or class IV (severe) at the time of screening Uncontrolled cardiac angina or symptomatic congestive heart failure (NYHA class III or IV) Patients must have a left ventricular ejection fraction > 30%, no uncontrolled arrhythmias or New York Heart Association class III-IV heart failure History of Class III or IV congestive heart failure, as defined by the New York Heart Association Classification of Congestive Heart Failure No symptomatic congestive heart failure (New York Heart Association class II, III, or IV) within 6 months prior to registration Symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV), or unstable angina pectoris Current New York Heart Association (NYHA) class II, III, or IV congestive heart failure or symptomatic heart failure within 60 days prior to the start of study drugs Symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV), or unstable angina pectoris Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) Uncontrolled congestive heart failure (NYHA II, III, IV). Symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV), unstable angina pectoris or congenital long QT syndrome New York Heart Association (NYHA) class II, NYHA class III, or IV congestive heart failure (any symptomatic heart failure) Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) History of uncontrolled congestive heart failure defined as New York Heart Association (NYHA) class III or greater New York Heart Association Class III or IV heart failure Class II, III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) Active congestive heart failure (New York Heart Association [NYHA] class III to IV), symptomatic ischemia, or conduction abnormalities uncontrolled by conventional intervention Patients with congestive heart failure, class III or IV, by the New York Heart Association (NYHA) criteria Uncontrolled malignant arrhythmias or clinical evidence of congestive heart failure (New York class IV) Clinical evidence of significant congestive heart failure (CHF) (New York Heart Association [NYHA] Class III or IV) Subject currently has Class III or IV New York Heart Association congestive heart failure. Symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV) Any uncontrolled congestive heart failure New York Heart Association class III or IV Uncontrolled hypertension or congestive heart failure Class III/IV per the New York Heart Association's Heart Failure Guidelines Class III or IV congestive heart failure by New York Heart Association Has heart failure of Class III or IV. Unstable angina, significant cardiac arrhythmia, or New York Heart Association (NYHA) class III or IV congestive heart failure Subjects with New York Heart Association (NYHA) Class III or IV congestive heart failure or LVEF <40% by echocardiogram (ECHO) or multi-gated acquisition (MUGA) scan within approximately 28 days of C1D1 Has heart failure of Class III or IV Congestive heart failure or prior history of New York Heart Association (NYHA) class III/ IV cardiac disease; Congestive heart failure New York Heart Association Class III or IV, or Class II with a recent decompensation requiring hospitalization within 4 weeks before screening. History of class III or IV congestive heart failure, as defined by the New York Heart Association Symptomatic congestive heart failure of New York Heart Association Class III or IV New York Heart Association class III or IV heart failure Current or history of New York Heart Association Class III or IV heart failure. Patients with diagnosed New York Heart Association (NYHA) class III-IV failure or documented ejection fraction (EF) < 30% New York Heart Association class III or IV heart failure Uncontrolled cardiac angina or symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV) Congestive Heart Failure NY Heart Association class III or IV New York Heart Association (NYHA) class IV congestive heart failure; Symptomatic congestive heart failure of New York heart Association Class III or IV New York Heart Association (NYHA) class III and IV congestive heart failure Congestive heart failure (New York Heart Association [NYHA] class III or IV) New York Heart Association (NYHA) class III and IV congestive heart failure Patients with uncontrolled congestive heart failure (New York Heart Association [NYHA] Class IV) Current or history of New York Heart Association Class III or IV heart failure Congestive heart failure (New York Heart Class III or IV).