Grade >= 2 neuropathy Baseline neuropathy of > grade 2 SAFETY RUN-IN: Patients with baseline grade 2 neuropathy >= grade 3 neuropathy at the time of enrollment Neuropathy > grade 1 CTCAE Grade > 2 neuropathy Neurosensory neuropathy > grade 2 at baseline. Neuropathy ? Grade 2. Patients with a history of grade >= 2 neuropathy Patients with >= grade 2 neuropathy Significant neuropathy > grade 2 at the time of first dose or within 14 days of enrollment Neuropathy > grade 1 Patients with any baseline grade 2 neuropathy Grade 3 baseline neuropathy Neuropathy: patients must have =< grade 1 neuropathy at enrollment Neuropathy =< grade 1 at the time of registration Diabetic neuropathy (any grade) Neuropathy grade >1 Neuropathy >= grade 1 Patient has baseline neuropathy of >= grade 2 Significant neuropathy (grade 3, grade 4) at the time of the first dose and/or within 14 days before enrollment Neuropathy > Grade 1 Neuropathy (?grade 2 CTCAE) Patients with >= grade 2 neuropathy No grade >= 2 neuropathy Ongoing grade >= 3 neuropathy Baseline neuropathy > grade 1 Patient has baseline neuropathy of > grade 2 Neuropathy Grade > 3 Grade <= 2 neuropathy Neurosensory neuropathy ? grade 2 at baseline. Neuropathy CTCAE grade > 2 Patients with > grade 1 neuropathy Subjects with >= grade 2 neuropathy Evidence of ? Grade 2 neuropathy Neuropathy > Grade 1. Patients with symptomatic neuropathy Patients with >= grade 2 neuropathy Significant neuropathy (? Grade 3) within the 14 days prior to randomization Subjects with >= grade 2 neuropathy Neurosensory neuropathy ? grade 2 at baseline Significant neuropathy >= grade 3 or grade 2 neuropathy with pain at baseline Significant neuropathy >= grade 3 or grade 2 neuropathy with pain at baseline > Grade 3 neuropathy Grade >1 neuropathy History of Grade ?2 neuropathy Patient has baseline neuropathy of >= grade 2 Neuropathy > grade 2 Significant neuropathy >= grade 3 or grade 2 neuropathy with pain at baseline ? Grade-2 neuropathy No current grade 2, 3, or 4 of neuropathy Patients with any neuropathy > Grade 1 Clinical evidence of neuropathy Significant neuropathy >= grade 3 at baseline Patients with any neuropathy. Patients with neuropathy > grade 1 Subject has Neuropathy ? Grade 2 at Screening. With < or = grade 2 neuropathy > grade 2 neuropathy Patients with grade III-IV neuropathy Grade 2 or above neuropathy Presence of ? Grade 2 neuropathy. Neuropathy Grade 3 or more Grade >= 2 neuropathy Neuropathy >= grade 2 (moderate neuropathy that limits instrumental activities of daily living) Subject has ? CTCAE v4.03 Grade 2 neuropathy. Neuropathy: no baseline neuropathy grade > 2 Known diabetic neuropathy Greater than Grade 2 neuropathy or ? Grade 2 neuropathy with pain at baseline, regardless of whether or not the patient is currently receiving medication Has neuropathy ? Grade 2.