Patients with right bundle branch block plus left anterior hemiblock, bifascicular block are excluded
Right bundle branch block + left anterior hemiblock (bifascicular block)
Known history of symptomatic congestive heart failure (New York Heart Association III-IV), symptomatic or poorly controlled cardiac arrhythmia, complete left bundle branch block, bifascicular block, or any clinically significant ST segment and/or T-wave abnormalities, QTcF > 450 msec prior to randomization.
Complete left bundle branch or bifascicular block.
No presence of left bundle branch blocks (LBBB)
History or presence of an abnormal electrocardiogram (ECG) that is clinically significant in the investigator's opinion, including complete left bundle branch block, second- or third degree heart block, or evidence of prior myocardial infarction Exclusions Related to Infections
Significant uncontrolled cardiac arrhythmias, including ventricular arrhythmias, congenital long QT syndrome, symptomatic atrial fibrillation, symptomatic bradycardia, right bundle branch block plus left anterior hemiblock or bifasicular block
Electrocardiogram (ECG) abnormalities:\r\n* Prolonged corrected QT (QTc) (Bazette’s or Fredericia’s correction) interval on screening ECG (>= 450 msec)\r\n* QRS ? 120 msec\r\n* PR ? 210 msec\r\n* Any prior history, or current evidence of second- or third-degree heart block\r\n* Heart rate ? 40 beats per minute at screening\r\n* ECG second degree heart block (Mobitz’s type 2 or Wenckebach)\r\n* Complete heart block\r\n* Left bundle branch block or bifascicular block (right bundle branch block and left anterior hemiblock together)\r\n* Episodes of ventricular tachycardia
History or presence of an abnormal electrocardiogram (ECG) that is clinically significant in the investigator's opinion, including complete left bundle branch block, second- or third-degree heart block, or evidence of prior myocardial infarction
Right bundle branch block and left anterior hemiblock (bifascicular block)
Any of the following concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study:\r\n* ST depression or elevation of >= 1.5 mm in 2 or more leads\r\n* Congenital long QT syndrome\r\n* History or presence of ventricular arrhythmias or atrial fibrillation\r\n* Clinically significant resting bradycardia (< 50 beats per minutes)\r\n* Complete left bundle branch block\r\n* Right bundle branch block + left anterior hemiblock (bifascicular block)
Known congestive heart failure and/ or a known decreased cardiac ejection fraction of < 45%. A baseline QT interval as corrected by Fridericia's formula (QTcF) > 480 msec, a complete left bundle branch block (defined as a QRS interval ? 120 msec in left bundle branch block form) or an incomplete left bundle branch block.
Any electrocardiograph (ECG) changes that interfere with QT interval interpretation (e.g., left bundle branch block, frequent premature ventricular contractions)
DOSE EXPANSION COHORT: History or presence of an abnormal ECG which, in the investigator's opinion, is clinically meaningful; screening QTcF interval > 480ms is excluded; subjects with left bundle branch block are excluded
Complete left bundle branch block
Right bundle branch block + left anterior hemiblock (bi-fascicular block)
History or presence of complete left bundle branch block, heart block, cardiac pacemaker or significant arrhythmia.
Abnormal ECGs that are clinically significant such as QT prolongation (QTc > 480 msec), clinically significant cardiac enlargement or hypertrophy, new bundle branch block or existing left bundle branch block, or signs of new, active ischemia a. Patients with evidence of prior infarction who are New York Heart Association (NYHA) functional class II, III, or IV are excluded, as are patients with marked arrhythmia such as Wolff Parkinson White pattern or complete atrioventricular (AV) dissociation
Complete left bundle branch block (LBBB)
Clinically significant cardiac arrhythmias, complete left bundle branch block, high-grade AV block
Complete left bundle branch, or bifasicular block.
Abnormal ECGs that are clinically significant such as QT prolongation (QTc > 480 msec), clinically significant cardiac enlargement or hypertrophy, new bundle branch block or existing left bundle branch block, or signs of new, active ischemia.
A baseline QT interval as corrected by Fridericia's formula (QTcF) > 450 msec, a complete left bundle branch block (defined as a QRS interval ? 120 msec in left bundle branch block form) or an incomplete left bundle branch block.
Complete left bundle branch block
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right or left bundle branch block
Complete left bundle branch or bifascicular block
Complete left bundle branch, or bifasicular, block.
Right bundle branch block + left anterior hemiblock (bifascicular block)
Right bundle branch block + left anterior hemiblock (bifascicular block).
A baseline QT interval as corrected by Fridericia's formula (QTcF) > 450 msec, a complete left bundle branch block (defined as a QRS interval ? 120 msec in left bundle branch block form) or an incomplete left bundle branch block.
Bundle branch block or QRS ? 120 msec
Complete left bundle branch block
Right bundle branch block and left anterior hemi block (bifascicular block)
Presence of left bundle branch block (LBBB)
Complete left bundle branch block
Right bundle branch block and left anterior hemiblock (bifascicular block)
Complete left bundle branch block;
Complete left bundle branch block;
Right bundle branch block + left anterior hemiblock (bifascicular block)
Presence of left bundle branch block (LBBB);
Presence of left bundle branch block (LBBB)
Patients with left bundle branch block (LBBB) and/or artificial pacemaker
Impaired cardiac function including any one of the following: complete left bundle branch block or use of a permanent cardiac pacemaker, congenital long QT syndrome, presence of ventricular tachyarrhythmias, clinically significant resting bradycardia (< 50 beats per minute), QT interval corrected by Fridericia's formula (QTcF) > 450 msec on screening electrocardiogram (ECG), or right bundle branch block + left anterior hemiblock (bifascicular block)
Complete left bundle branch block
Right bundle branch block plus left anterior or posterior hemiblock