Patients with markedly decreased visual acuity Markedly decreased visual acuity if attributed to other causes than GBM. Patients with macular degeneration with markedly decreased visual acuity, patients with markedly decreased visual acuity (no specific etiology) or uncontrolled glaucoma Patients with markedly decreased visual acuity in the opinion of the treating investigator after completion of screening ophthalmologic exam Patients with macular degeneration, uncontrolled glaucoma or markedly decreased visual acuity Patients with macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity based on physician’s assessment Patients with macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity Patients with known severe macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity Macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity. Patients with markedly decreased visual acuity