Platelet count >= 100,000/mL within 28 days prior to registration STEP I: Untransfused platelet count >= 75,000 cells/mm^3 (obtained within 28 days prior to randomization) Platelet count >= 100,000/ mL within 21 days prior to registration; patients must not have had a blood transfusion within 28 days prior to registration Platelet count >= 100,000 mcl obtained within 28 days prior to sub-study registration Platelet count >= 75,000/mcL; must be obtained within 28 days prior to registration Platelet count >= 100,000 mm^3; platelets >= 75,000 required for patients who received cycle 1 of mFOLFOX6 prior to registration Within 14 days of registration: Platelet count >= 75,000/mm^3 Obtained within 28 days prior randomization: platelet count must be >= 100,000/mm^3 Platelet (PLTs) count >= 100,000/mm^3 obtained =< 21 days prior to registration Platelet count >= 75,000/ mm^3 (=< 28 days prior to registration) Obtained =< 14 days prior to registration: Platelet count >= 100,000/mm^3 Obtained within 28 days prior to registration: Platelet count >= 60 x 10^9/L Platelet count >= 100 x 10^9/L performed within 30 days prior to the date of registration Obtained within 14 days prior to registration: Platelet count >= 150,000/uL Obtained =< 35 days prior to registration: platelet count >= 100,000/mm^3 Platelet count >= 50,000/mm^3, obtained =< 14 days prior to registration Platelet count >= 25 x 10^9/L (obtained =< 14 days prior to registration) Platelet count >= 100,000/mm^3 =< 28 days prior to registration Obtained =< 14 days prior to registration: Platelet count >= 75000/mm^3 Obtained ? 14 days prior to registration: Platelet count ? 75000/mm^3; Note: Platelet transfusion is not allowed ? 3 days prior to registration Platelet count >= 100,000 / ml obtained =< 14 days prior to study initiation Obtained within 21 days prior to cycle 1, day 1: platelet count >= 75,000/mm3 Platelet count ? 100,000/mm^3 (100 × 10^9/L) obtained ? 14 days prior to randomization Platelet count >= 100,000/mm^3 obtained =< 14 days prior to registration Obtained =< 14 days prior to registration: Platelet count >= 100,000/mm^3 Obtained =< 14 days prior to registration: Platelet count >= 100,000/mm^3 Obtained =< 14 days prior to registration: Platelet count >= 75 x 10^9/L unless the participant has >= 50% bone marrow infiltration in which case a platelet count of >= 50 x 10^9/L is allowed Obtained =< 28 days prior to registration: Platelet count >= 100,000/mm^3 Within 14 days prior to registration: Platelet count >= 100 x 10^9/L Platelet count >= 100,000/mm^3 obtained =< 7 days prior to registration Platelet count >= 75,000/mm^3 obtained =< 14 days prior to registration Platelet count >= 75,000/mm^3 (obtained =< 14 days prior to registration)\r\n* Criteria must be met without a transfusion within four weeks of registration Platelet count >= 100 x 10^9/L (>= 100,000 per mm^3) within 28 days prior to study registration Untransfused platelet count >= 75000/mm^3, obtained =< 14 days prior to registration Obtained =< 7 days prior to registration: Platelet count >= 100,000/mm^3 Platelet count >= 100,000/mm^3 obtained =< 14 days prior to registration Within 60 days prior to registration, hematologic minimal values: platelet count > 100,000/mm^3 Obtained =< 14 days prior to randomization: Platelet count >= 100,000/mm^3 Obtained =< 14 days prior to registration: Platelet count >= 30,000/mm^3 Platelet count >= 75,000/mm^3, obtained =< 7 days prior to registration Platelet count >= 60,000/ucl obtained within 28 days prior to registration Patients must have an ANC ? 1,500/?l and a platelet count ? 100,000/?l obtained within 14 days prior to registration. Platelet count of >= 100 x 10^9/L (performed within 14 days prior to registration) Platelet count >= 75,000/mm^3 obtained =< 14 days prior to registration Obtained =< 28 days prior to randomization: \r\nPlatelet count >= 100,000/mm^3 Platelet count >= 50,000/mm^3 obtained =< 14 days prior to registration Platelet count >= 75000/mm^3, obtained =< 14 days prior to registration Platelet count >= 75,000 /mm^3 within 28 days prior to registration. Obtained =< 21 days prior to registration: Platelet count >= 100,000/mm^3 Obtained =< 7 days prior to registration: Platelet count >= 100,000/uL Within 14 days prior to registration: Platelet count >= 100 x 10^9/L Platelet count >= 100,000/mm^3 (100 x 10^9 /L) obtained =< 28 days prior to registration Platelet count >= 100,000/mm^3, obtained =< 7 days prior to registration ARM A: obtained =< 14 days prior to registration: \r\n* Platelet count >= 80,000/mm^3 ARM B: obtained =< 14 days prior to registration: \r\n* Platelet count >= 100,000/mm^3 Platelet count >= 100,000/mm^3 or >= 100 x 10^9/L (must be >= 7 days after most recent transfusion), obtained =< 14 days prior to registration Obtained within 30 days prior to registration: Platelet > 100 k Obtained =< 7 days prior to registration: Platelet count >= 100,000/mm^3 Platelet count >= 100,000 mcl obtained within 28 days prior to Step 2 re-registration Platelet count >= 100,000/mm^3 (obtained =< 14 days prior to registration) Platelet count >= 100,000 mcl obtained within 28 days prior to Step 2 re-registration Platelet count >= 100,000 mcl obtained within 28 days prior to step 2 re-registration CLINICAL/LABORATORY CRITERIA: Platelet count >= 100,000/mcL; these results must be obtained within 28 days prior to registration Platelet count >= 100,000/mcL obtained within 28 days prior to registration Platelet count >= 100,000 mcl obtained within 28 days prior to RE-TREATMENT registration Platelet count >= 100,000/mm^3, obtained =< 21 days prior to registration Platelet count >= 75,000/mm^3 obtained =< 7 days prior to registration Platelet >= 100 x 10^9/L (> 100,000 per mm^3), obtained within 14 days prior to first treatment Platelet count > 100 x 10^9/L (within 7 days prior to registration); or Platelet count >= 100,000/mm^3 obtained =< 14 days prior to registration Platelet count > 100,000/mm^3 (obtained =< 7 days prior to randomization) Platelet count >= 100,000/mm^3 obtained =<14 days prior to randomization Obtained within 14 days prior to registration: Platelet count >= 100,000/ul Platelet count >= 100,000/mm^3 obtained =< 14 days prior to randomization Untransfused platelet count >= 75000/mL (obtained =< 14 days prior to registration) Platelet >= 100 x 10^9/L (> 100,00 per mm^3), obtained within 14 days prior to first treatment Platelet count of >= 100,000/microliters within 90 days prior to registration Obtained =< 30 days prior to randomization: Platelet count >= 50,000/mm^3 Platelet count >= 50,000/mm^3 obtained =< 30 days prior to registration Platelet count >= 100,000/microliter obtained =< 45 days prior to randomization Platelet count of >= 100,000/mm^3, performed within 28 days prior to registration