Active infection or chronic infection requiring chronic suppressive antibiotics Active infection requiring treatment with antibiotics Patients must not have a serious intercurrent illness, including ongoing or active infection requiring parental antibiotics Active infection or chronic infection requiring chronic suppressive antibiotics. Active infections requiring antibiotics, physician monitoring or recurrent fevers >100.4?F (38.0?C) associated with a clinical diagnosis of active infection Active infection requiring IV antibiotics at day 1 of cycle 1 Active infection requiring IV antibiotics within 2 weeks of study dose No active infection requiring antibiotics Active infection requiring antibiotics Active infection requiring iv antibiotics at day 1 of cycle 1 EXCLUSION - PROCUREMENT: Active infection requiring antibiotics Active infection requiring IV antibiotics on Cycle 1, Day 1 If they have a major systemic infection requiring antibiotics 72 hours or less prior to the first dose of study drug Patients should not have any evidence of active or uncontrolled infection requiring treatment with antibiotics Currently using antibiotics and/or anti fungal agent (however, topical antibiotics are permitted). Active infection requiring systemic antibiotics or antifungals within 7 days prior to first dose of study drug; exception: tetracycline family antibiotics (tetracycline, doxycycline, minocycline) administered for the management of cetuximab-related rash may be continued per the investigator’s judgment Active infection requiring the use of systemic antibiotics Participant has an active infection requiring IV antibiotics Active infection requiring systemic antibiotics within 2 weeks prior to cycle 1, day 1; prophylactic short-term antibiotics will be allowed Has an active infection requiring systemic therapy with IV antibiotics Presence of an serious illness, uncontrolled illness, or active infection requiring IV antibiotics. Active infection or chronic infection requiring chronic suppressive antibiotics Have active infection requiring antibiotics Has an active infection requiring systemic antibiotics within 10 days of registration Patients should not be on antibiotics for any infection but post operative antibiotics are allowed if used prophylactically but should be completed prior to starting RT Known HIV-1 or any active infection requiring IV antibiotics Major systemic infection requiring antibiotics 72 hours or less prior to first dose of study drug Active infection requiring IV antibiotics 7 days before enrollment Patients must not have an active major systemic infection requiring systemic antibiotics 72 hours or less prior to the first dose of study drug Patients should be free of active infection requiring antibiotics Active infection requiring systemic therapy with IV antibiotics Active infection or chronic infection requiring chronic suppressive antibiotics. Active infection requiring antibiotics Active infection not adequately responding to appropriate antibiotics (i.e. ongoing temperatures of >= 38 degree Celsius) Active infection requiring antibiotics Active infection requiring treatment with systemic antibiotics or systemic anti-fungal agents Active infection or chronic infection requiring chronic suppressive antibiotics. Treated with antibiotics for infection within one week prior to study entry. If they have a major systemic infection requiring antibiotics 72 hours or less prior to the first dose of study drug Treatment with antibiotics within 2 weeks (14 days) of dosing Subjects with an active infection requiring antibiotics or at an increased risk of latent infection that may affect safe study participation Subjects with active infection requiring IV antibiotics within 2 weeks of study enrollment (day 1) are excluded Active infection-must be afebrile and off antibiotics Participants with an active infection requiring antibiotics are excluded (a positive screening urinalysis may be repeated) Uncontrolled infection requiring active treatment (systemic antibiotics, anti-virals, or anti-fungals) within 14 days Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment unless the patient is felt to have fully recovered and any antibiotics that are continued are either beta lactam antibiotics or are specifically allowed on study Active infection or chronic infection requiring chronic suppressive antibiotics Evidence of any active infection requiring hospitalization or IV antibiotics within 2 weeks prior to study enrolment. Active infection, or chronic infection requiring chronic suppressive antibiotics. Active pulmonary infection not responsive to conventional antibiotics Any known HIV infection or AIDS or any concurrent infection requiring IV antibiotics Has an active infection requiring systemic antibiotics within 7 days of registration Active infection or antibiotics within 48 hours prior to study Active infection within the 14 days prior to randomization requiring systemic antibiotics Active infection requiring treatment with IV antibiotics or hospitalized for treatment of an active infection in 4 wks prior to starting dose of AMG 592. Presence of acute active infection requiring antibiotics Serious active infection requiring i.v. antibiotics and/or hospitalization at study entry Patients with an active infection requiring antibiotics Active infection not adequately responding to appropriate antibiotics (i.e. ongoing temperatures of >= 38 degree Celsius) Patients should be free of active infection requiring antibiotics Uncontrolled infection requiring ongoing antibiotics Current severe, uncontrolled systemic disease including an ongoing, active infection requiring treatment with antibiotics Active infection involving IV antibiotics within 2 weeks prior to C1D1 Active uncontrolled serious infection or sepsis at study enrollment; patients receiving antibiotics for infections that are under control may be included in the study Active infection involving IV antibiotics within 2 weeks prior to C1D1 Patients should not have any evidence of active or uncontrolled infection requiring treatment with antibiotics Has an active infection requiring antibiotics Ongoing or active infection requiring parental antibiotics on Day 1 Known active infection requiring antibiotics within 7 days of the start of treatment (day 0) Ongoing or active infection requiring IV antibiotics Active infection requiring antibiotics Treatment with antibiotics within 2 weeks (14 days) of dosing. Has an active infection requiring systemic antibiotics. Active infection requiring antibiotics Ongoing or active infection requiring antibiotics; Has an active infection requiring systemic antibiotics Active infection requiring IV antibiotics Active infection requiring antibiotics Active infection requiring antibiotics Active infection requiring antibiotics Active infection requiring IV antibiotics within 2 weeks prior to screening Active infection requiring iv antibiotics Uncontrolled infection requiring systematic antibiotics within 14 days before the first dose of study drug Has uncontrolled infection requiring systematic antibiotics Active infection requiring (IV) antibiotics within 2 weeks of study enrollment Active infection requiring IV antibiotics Any infection requiring antibiotics within the past 2 weeks. Serious infection requiring antibiotics Pneumonia requiring antibiotics at the time of study enrollment Patients with a previous or current line infection are ineligible until 14 days after the completion of antibiotics Active infection requiring antibiotics No use of antibiotics in the previous 3 months; or current regular use of antibiotics Patients should be free of active infection requiring antibiotics A non?urologic bacterial infection requiring active treatment with antibiotics Patients with active and/or uncontrolled infections or who are still recovering from an infection\r\n* Actively febrile patients with uncertain etiology of febrile episode\r\n* All antibiotics should be completed at least 1 week (7 days) prior to collection\r\n* No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics\r\n* Note: Use of antibiotics for pre-operative prophylaxis is not an exclusion The participant has an active infection (requiring I.V antibiotics), including tuberculosis.