Allergy or hypersensitivity to components of the cobimetinib formulations No known history of severe hypersensitivity reactions to any of the components of efatutazone or paclitaxel formulations Previously identified allergy or hypersensitivity to components of the cabozantinib formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Previously identified hypersensitivity to components of the formulations used in this study Known allergy or hypersensitivity to the components of the doxorubicin, cyclophosphamide, carboplatin, or paclitaxel formulations. Known allergy or hypersensitivity to liposomal or pegylated G-CSF formulations. Known allergy or hypersensitivity to the components of the formulations of atezolizumab, nab-paclitaxel, cyclophosphamide, or doxorubicin, filgrastim or pegfilgrastim Known allergy or hypersensitivity to phosphatidylinositol 3 kinase (PI3K) inhibitors or any component of the formulations used in this study. History of severe hypersensitivity reactions to components of the cobimetinib, atezolizumab, or pembrolizumab formulations Previously identified allergy or hypersensitivity to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Has a previously identified allergy or hypersensitivity to components of the study treatment formulations Known allergy or hypersensitivity to study drug formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Patients with a known allergy to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations Patients must not have any known allergy or reaction to any component of the nivolumab and ipilimumab formulations Known allergy or hypersensitivity to IP formulations or to other human monoclonal antibodies Previously identified allergy or hypersensitivity to components of the study treatment formulations Allergy or hypersensitivity to components of the cobimetinib formulations Patient has a known allergy to any component of the study treatment formulations Previously identified allergy or hypersensitivity to components of the study treatment formulations. Allergy or hypersensitivity to components of the cobimetinib formulations The patient has a previously-identified allergy or hypersensitivity to components of the study treatment formulations. History of serious allergy or reaction to any component of RICE or RDHAP formulations that would prevent administration