No evidence of residual cancer or metastasis after surgery Patients must have advanced or metastatic MCC defined as evidence of distant metastasis(es) on imaging\r\n* Patients with locoregionally confined disease are not eligible Patients with evidence of clinical T4b (unresectable) or M1 (distant metastasis) according to the AJCC 2010 staging system will be ineligible Patients with distant metastasis (e.g. spread to distant areas outside the regional lymph nodes, clearly non contiguous areas of bone involvement, or distant metastasis to lung, brain, liver or other visceral organs) are ineligible Known evidence of distant metastasis. Any known nodal (N1) or distant metastasis (M1) Distant metastasis Evidence of distant metastasis on upright chest x-ray (CXR), computed tomography (CT) or other staging studies Evidence of distant metastasis (M1) involvement. Any evidence of metastasis to distant organs (liver, lung, peritoneum) No evidence of distant metastasis either prior to or after induction chemotherapy. No distant metastasis as verified by one of the study investigators Distant metastasis or adenopathy below the clavicles Evidence of distant metastases or lymph node metastasis (es) that was not within the radiation field Barcelona Clinic Liver Cancer (BCLC) D = patients with distant metastasis Distant metastasis or adenopathy below the clavicles Patients with evidence of liver metastasis are excluded Distant metastasis Histologically (archival tissue) confirmed adenocarcinoma of the rectum that begins within 12 cm of the anal verge as determined by sigmoidoscopy and/or colonoscopy with no evidence of distant metastasis No evidence of distant metastasis either prior to or after induction chemotherapy Evidence of distant metastasis Distant metastasis to the lung, bone or brain; typically, most stage 4 uterine papillary serous cancer (UPSC) is confined to the abdomen on presentation Any evidence of metastasis to distant organs (liver, lung, peritoneum) Distant metastasis Evidence of distant metastasis on upright chest x-ray (CXR), computed tomography (CT) or other staging studies Evidence of metastasis No evidence of distant metastasis Evidence of distant metastasis apparent prior to randomization Patients with distant metastasis Patients must have pathologically-confirmed, previously untreated, stage III-IV (excluding N3 or T4) squamous cell carcinoma of the oropharynx, without evidence of distant metastasis Definitive clinical or radiographic evidence of distant metastasis or adenopathy below the clavicles Histological confirmation of recurrence of chest wall with or without distant metastasis disease Has local or distant metastasis Subjects with metastasis limited to the bone only are excluded. However, subjects with current metastasis limited to the bone only and with a history of distant metastasis are eligible. Subjects with current metastasis limited to the bone only and with current breast tissue lesion are eligible. Any evidence of lymph node or distant metastasis. Patients with any distant metastasis (liver, lung, bone, brain) No evidence of distant metastasis either prior to or after induction chemotherapy REGISTRATION EXCLUSION CRITERIA: Evidence of distant metastasis present by CT scan, bone scan, or physical exam Radiographic evidence of regional or distant metastasis at the time of study enrollment or at the time of diagnosis No clinical, radiographic or other evidence of distant metastasis Patients with distant metastasis and life expectancy >= 3 months are eligible Cannot have distant metastasis (M0) Distant metastasis to organs (local recurrence and regional lymph node recurrence are not considered as distant metastasis) other than bone Prior radiation to site(s) of distant metastasis of bone Have confirmed distant metastasis with or without local recurrence Patients with metastatic BCC, histologic confirmation of distant BCC metastasis At least 2 organs involved in metastatic gastric tumor (including at least lung or liver or both) in addition to the site of primary tumor, where metastasis in distant lymph nodes, peritoneal metastasis, and malignant pleural effusion may count as \organs\ in this context No evidence of distant metastasis either prior to or after induction chemotherapy Evidence of distant metastasis on upright chest X-ray (CXR), CT or other staging studies Evidence of distant metastasis Documented evidence of distant metastasis or locoregional recurrence per required assessments within 28 days prior to starting study therapy. Note: Histologic confirmation of metastatic disease is not required. Metastatic disease, including lymph nodes or distant metastasis No evidence of distant metastasis representing stage IV metastatic disease History of histologically or cytologically proven breast cancer at stage I, II and III, without evidence of distant metastasis History of histologically or cytologically proven breast cancer at stage I, II and III without evidence of distant metastasis Evidence of metastasis Evidence of distant prostate cancer, i.e., including lymph nodes and/or metastasis of cancer on imaging Evidence of peritoneal or distant metastasis on preoperative imaging Evidence of metastasis